Target Description

Type Detail
Target ID T18LX5
Protein Name Neutrophil elastase
Uniprot ID P08246
Protein Name Alias EC 3.4.21.37;  Bone marrow serine protease;  Elastase-2;  Human leukocyte elastase;  HLE;  Medullasin;  PMN elastase
Gene ID 1991
Gene Symbol ELANE
Gene Alias ELA2
TTD T40332: Clinical Trial target
Pfam PF00089
GO
0002438:acute inflammatory response to antigenic stimulus

0050728:negative regulation of inflammatory response

0043406:positive regulation of MAP kinase activity

0004252:serine-type endopeptidase activity

0032757:positive regulation of interleukin-8 production

0004175:endopeptidase activity

0070947:neutrophil-mediated killing of fungus

0050922:negative regulation of chemotaxis

0048661:positive regulation of smooth muscle cell proliferation

0003714:transcription corepressor activity

0032717:negative regulation of interleukin-8 production

0030141:secretory granule

0006909:phagocytosis

0032496:response to lipopolysaccharide

0062023:collagen-containing extracellular matrix

0001878:response to yeast

0005615:extracellular space

0017053:transcription repressor complex

0035578:azurophil granule lumen

0032682:negative regulation of chemokine production

0002812:biosynthetic process of antibacterial peptides active against Gram-negative bacteria

0022617:extracellular matrix disassembly

0009411:response to UV

0009986:cell surface

0070062:extracellular exosome

0050778:positive regulation of immune response

0002523:leukocyte migration involved in inflammatory response

0000122:negative regulation of transcription by RNA polymerase II

0006874:cellular calcium ion homeostasis

0042742:defense response to bacterium

0043312:neutrophil degranulation

0005576:extracellular region

0035580:specific granule lumen

0006508:proteolysis

0045335:phagocytic vesicle

0070945:neutrophil-mediated killing of gram-negative bacterium

0002020:protease binding

0008233:peptidase activity

0005737:cytoplasm

0019955:cytokine binding

1903238:positive regulation of leukocyte tethering or rolling

0030163:protein catabolic process

0019730:antimicrobial humoral response

0008201:heparin binding

PDB 5A8Y ; 1B0F ; 6F5M ; 1PPF ; 1HNE ; 5A09 ; 3Q77 ; 5ABW ; 6E69 ; 4NZL ; 2RG3 ; 5A8Z ; 7CBK ; 5A8X ; 3Q76 ; 5A0B ; 5A0C ; 4WVP ; 1H1B ; 1PPG ; 5A0A ; 2Z7F ; 6SMA
Drugbank DB00019 ; DB03925 ; DB02341 ; DB05161 ; DB00058 ; DB00099
KEGG hsa:1991

Related Compounds  (Total: 3)

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C0046
Name: Epigallocatechin
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C0447
Name: Thymol
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C0709
Name: 2-Nonenal


Related Herbs  (Total: 132)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1109 Bai Hua She She Cao白花蛇舌草 Spreading hedyitisOldenlandia diffusa
H1112 Gua Lou Ren(1)栝楼仁 NATrichosanthes kirilowii
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0299 Niu Zhi牛至 wild marjoramOriganum vulgare
H0198 Ma Huang Gao麻黄膏 Chinese ephedraEphedra sinica
H0342 Qing Hao青蒿 sweet wormwoodArtemisia carvifolia
H0418 Shan Yin Chen山茵陈 Capillary wormwoodArtemisia capillaris
H0590 Wei Ling威灵 Chinese clematisClematis chinensis
H0822 Zhou Ye Xiang Ru皱叶香薷 Haichow elsholtziaElsholtzia splendens
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H0897 Chuan Lian川楝 ChinaberryMelia azedarach
H0118 Kun Ming Shan Hai Tang昆明山海棠 Glaucousback threewingnutTripterygium hypoglaucum
H1111 Gua Lou Gen栝楼根 NATrichosanthes kirilowii
H0992 Ding Xiang Luo Le You丁香罗勒油 Ocimum oilOleum ocimi gratissimi
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H1173 Hei Chou黑丑 Pharbitis seedSemen pharbitidis
H1140 Guo Gang Long过岗龙 NAEntada phaseoloides
H0893 Chuan Xiong Jin Gao川芎浸膏 cnidium officinaleCnidium officinale
H1232 Huang Cao Wu黄草乌 NAAconitum vilmorinianum
H0764 Yu Xing Cao鱼腥草 Heartleaf houttuyniaHouttuynia cordata
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H0539 Tian Hua Fen天花粉 Mongolian snakegourd rootTrichosanthes kirilowii
H0150 Ling Xian灵仙 root and rhizome of smilaxRadix smilacis
H0181 Luo Bu Ma罗布麻 DogbaneApocynum venetum
H1090 Gao Ben藁本 Chinese ligusticumLigusticum sinense
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H1004 Bai Cha白茶 White teaCamellia sinensis
H0818 Zhi Zi栀子 Cape jasmine fruitGardenia jasminoides
H1011 Bai Chou白丑 Pharbitis seedSemen pharbitidis
H0892 Chuan Xiong川芎 cnidium officinaleCnidium officinale
H0246 Mi Ma Huang蜜麻黄 Ephedra equisetinEphedra sinica
H0719 Chen Pi陈皮 Dried tangerine peelPericarpium citri reticulatae
H0416 Shan Shen山参 NAPanax ginseng
H0604 Wu Wei Teng五味藤 NASecuridaca inappendiculata
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0527 Tao PeachPrunus persica
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H0647 Xiang Ru香薷 Haichow elsholtziaElsholtzia splendens
H0451 Shi Chang Pu Jin Gao石菖蒲浸膏 Grassleaved sweetflagAcorus tatarinowii
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H0020 Ji Yan Cao鸡眼草 Striate kummerowiaKummerowia striata
H0229 Mao Da Ding Cao毛大丁草 Pilose gerberaGerbera piloselloides
H0667 Xiao Qing Pi小青皮 Green tangerine peelPericarpium citri reticulatae viride
H1097 Gong Ding Xiang公丁香 NASyzygium aromaticum
H0629 Xi Xin细辛 Siebold wildgingerAsarum sieboldii
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H0868 Chuan Du Huo川独活 Doubleteeth pubescent angelicaAngelica pubescens
H0071 Bai Ye柏叶 Chinese arborvitae twigPlatycladus orientalis
H0565 Tu Bie Chong土鳖虫 CockroachEupolyphaga sinensis
H0650 Chai Hu柴胡 Chinese thorowaxBupleurum chinense
H0714 Yan Tai Chai Hu烟台柴胡 Chinese thorowaxBupleurum chinense
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0424 Shan Zhi山栀 Cape jasmineGardenia jasminoides
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H1106 Gua Lou Ren瓜蒌仁 NATrichosanthes kirilowii
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H0554 Tie Si Wei Ling Xian铁丝威灵仙 root and rhizome of smilaxRadix smilacis
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H1198 Hou Tou Jun猴头菌 Bearded tooth carpophoreHericium erinaceus
H0551 Cang Zhu苍术 Swordlike atractylodesAtractylodes lancea
H0343 Qing Hao Zi青蒿子 sweet wormwoodArtemisia carvifolia
H1128 Bai Jiang败酱 Whiteflower patriniaPatrinia villosa
H0990 Ding Xiang丁香 Clove treeSyzygium aromaticum
H0188 Lv Cao葎草 Japanese hopHumulus japonicus
H1054 Fu Ling Pi茯苓皮 Indian bread peelExodermis poria
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H0989 Ding Kui Cao丁葵草 Herb of twinleaf zorniaKummerowia striata
H0679 Xing Ren杏仁 Apricot seedPrunus armeniaca
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H1108 Gua Lou Shi栝蒌实 NATrichosanthes kirilowii
H0108 Ku Lian Pi苦楝皮 Chinaberry-tree barkMelia azedarach
H0357 Ren Shen人参 GinsengPanax ginseng
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0729 Ye Ju Hua野菊花 Indian wild chrysanthemum flowerChrysanthemum indicum
H1105 Gua Lou Pi瓜蒌皮 NATrichosanthes kirilowii
H0361 Ren Zi Cao人字草 Herb of twinleaf zorniaKummerowia striata
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H0200 Ma Huang Gen麻黄根 Chinese ephedra rootEphedra sinica
H0306 Pei Lan佩兰 FortuneEupatorium fortunei
H0088 Ju He橘核 Tangerine seedCitrus reticulata
H0585 Tu Yin Chen Hao土茵陈蒿 Capillary wormwoodArtemisia capillaris
H0674 Xin Yi辛夷 Lily magnolia budsMagnolia liliflora
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H0113 Ban Bian Lian半边莲 Chinese lobeliaLobelia chinensis
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0692 Xue Ren Shen血人参 NALespedeza bicolor
H0592 Wei Ling Xian威灵仙 Chinese clematisClematis chinensis
H0665 Chai Hu Shao柴胡梢 Chinese thorowaxBupleurum chinense
H0201 Ma Huang Jin Gao麻黄浸膏 Chinese ephedraEphedra sinica
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0109 Ku Lian Zi苦楝子 NAMelia azedarach
H0013 Ji Shi Teng鸡矢藤 FevervinePaederia scandens
H0721 Yang Mei Gen杨梅根 Myrica rubra sieb. et zuccMyrica rubra
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0745 Yin Chen Hao茵陈蒿 Capillary wormwoodArtemisia capillaris
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0093 Ju Pi橘皮 Tangerine pericarpCitrus reticulata
H0452 Shi Chang Pu Qing Gao石菖蒲清膏 Grassleaved sweetflagAcorus tatarinowii
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H1104 Gua Lou瓜蒌 NATrichosanthes kirilowii
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H1141 Guo Gang Long Jin Gao过岗龙浸膏 NAEntada phaseoloides
H1211 Bai Mei白眉 pilose gerbera herbGerbera piloselloides
H0746 Yin Chen Hao Gan Jin Gao茵陈蒿干浸膏 Capillary wormwoodArtemisia capillaris
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H0920 Da Ban Bian Lian大半边莲 Asian lobeliaLobelia chinensis
H0197 Ma Huang麻黄 Chinese ephedraEphedra sinica
H1009 Du Huo独活 Doubleteeth pubescent angelicaAngelica pubescens
H1029 Fang Er Cha方儿茶 khair in hindiSenegalia catechu
H0819 Zhi Zi Jin Gao栀子浸膏 Cape jasmine fruitGardenia jasminoides
H0678 Xin Yi Ren辛夷仁 MagnoliaMagnolia liliflora
H0450 Shi Chang Pu石菖蒲 Grassleaved sweetflagAcorus tatarinowii
H0976 Di Qing Pi地青皮 NAPericarpium citri reticulatae viride
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H0675 Xin Yi Hua辛夷花 MagnoliaMagnolia liliflora
H0763 Yu Mi Xu玉米须 Maize styleZea mays
H0676 Xin Yi Hua Jin Gao Fen辛夷花浸膏粉 MagnoliaMagnolia liliflora
H0659 Chai Hu Jin Gao柴胡浸膏 Chinese thorowaxBupleurum chinense
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H0797 Zhen Zhu Cai珍珠菜 Clethra loosestrifeLysimachia clethroides
H1107 Gua Lou Ren Shuang瓜蒌仁霜 NATrichosanthes kirilowii
H0347 Qing Pi青皮 Green tangerine peelPericarpium citri reticulatae viride
H0457 Shi Er石耳 Rock-EarsUmbilicaria esculenta
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata