Target Description

Type Detail
Target ID T87O4D
Protein Name Mitogen-activated protein kinase 7
Uniprot ID Q13164
Protein Name Alias MAP kinase 7;  MAPK 7;  EC 2.7.11.24;  Big MAP kinase 1;  BMK-1;  Extracellular signal-regulated kinase 5;  ERK-5
Gene ID 5598
Gene Symbol MAPK7
Gene Alias BMK1;  ERK5;  PRKM7
TTD T70851: Patented target
Pfam PF00069
GO
2001240:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

0035556:intracellular signal transduction

2000352:negative regulation of endothelial cell apoptotic process

0045765:regulation of angiogenesis

0005524:ATP binding

0070301:cellular response to hydrogen peroxide

0051247:positive regulation of protein metabolic process

0036003:positive regulation of transcription from RNA polymerase II promoter in response to stress

0106311:protein threonine kinase activity

0060761:negative regulation of response to cytokine stimulus

1902176:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

0018105:peptidyl-serine phosphorylation

0010468:regulation of gene expression

0070885:negative regulation of calcineurin-NFAT signaling cascade

0005829:cytosol

0005737:cytoplasm

0005654:nucleoplasm

0051344:negative regulation of cyclic-nucleotide phosphodiesterase activity

0007049:cell cycle

0019933:cAMP-mediated signaling

0045944:positive regulation of transcription by RNA polymerase II

0016605:PML body

0050728:negative regulation of inflammatory response

0071499:cellular response to laminar fluid shear stress

0005634:nucleus

0071363:cellular response to growth factor stimulus

0007411:axon guidance

0071560:cellular response to transforming growth factor beta stimulus

0106310:protein serine kinase activity

0007165:signal transduction

0051019:mitogen-activated protein kinase binding

0004707:MAP kinase activity

0034115:negative regulation of heterotypic cell-cell adhesion

PDB 6HKN ; 4ZSL ; 4IC7 ; 4ZSJ ; 5BYZ ; 6HKM ; 2Q8Y ; 4ZSG ; 4IC8 ; 5BYY ; 4B99 ; 5O7I
Drugbank DB00945 ; DB12010 ; DB01017
KEGG hsa:5598

Related Compounds  (Total: 3)

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C0483
Name: Vitexin
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C0948
Name: aldosterone
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C1103
Name: Baccharin


Related Herbs  (Total: 55)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0985 Dian Zhu Ye滇竹叶 Bamboo leavesPhyllostachys nigra
H0277 Nan Ban Lan Gen南板蓝根 Indigowoad rootBaphicacanthus cusia
H0552 Tie Sao Zhou铁扫帚 Sericea lespedezaLespedeza cuneata
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H0423 Shan Zha Ye山楂叶 NACrataegi folium
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H0216 Man Jing Ye蔓荆叶 Threeleaf chastetree leafVitex trifolia
H0217 Man Jing Zi蔓荆子 Threeleaf chastetree fruitVitex trifolia
H0357 Ren Shen人参 GinsengPanax ginseng
H1203 Hu Ji Sheng槲寄生 Colored mistletoeViscum coloratum
H1246 Huang Pi Ye黄皮叶 Chinese wampee leafClausena lansium
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0233 Mao Liang Mian Zhen毛两面针 NAZanthoxylum nitidum
H0336 Qin Jiao秦艽 large-leaved gentianGentiana macrophylla
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0020 Ji Yan Cao鸡眼草 Striate kummerowiaKummerowia striata
H0327 Qian Li Guang千里光 Climbing groundselSenecio scandens
H0837 Zhu Ye竹叶 Bamboo leavesPhyllostachys nigra
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H0764 Yu Xing Cao鱼腥草 Heartleaf houttuyniaHouttuynia cordata
H0722 Yang Nai Nai Ye羊奶奶叶 NAElaeagnus pungens
H0705 Yan Hu Lu Ba盐胡芦巴 FenugreekTrigonella foenum-graecum
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0188 Lv Cao葎草 Japanese hopHumulus japonicus
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H1211 Bai Mei白眉 pilose gerbera herbGerbera piloselloides
H0229 Mao Da Ding Cao毛大丁草 Pilose gerberaGerbera piloselloides
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H0668 Xiao Ye Huang Yang小叶黄杨 Small-leaved boxBuxus microphylla
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0989 Ding Kui Cao丁葵草 Herb of twinleaf zorniaKummerowia striata
H1210 Hu Tui Zi Ye胡颓子叶 NAElaeagnus pungens
H0361 Ren Zi Cao人字草 Herb of twinleaf zorniaKummerowia striata
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H0468 Shi Wei石韦 Japanese felt fern frondPyrrosia lingua
H1221 Hua Xiang Shu Guo Xu化香树果序 NAPlatycarya strobilacea
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H0524 Tan Xiang檀香 SandalwoodSantalum album
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H1220 Hua Xiang Shu Guo化香树果 NAPlatycarya strobilacea
H0034 Jiao Gu Lan绞股蓝 Fiveleaf gynostemmaGynostemma pentaphyllum
H0416 Shan Shen山参 NAPanax ginseng
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H0278 Nan Ban Lan Gen Jin Gao Fen南板蓝根浸膏粉 Indigowoad rootBaphicacanthus cusia
H0954 Dan Zhu Ye淡竹叶 Common lophatherumLophatherum gracile
H0337 Qin Jiao Hua秦艽花 large-leaved gentian flowerGentiana straminea
H0204 Ma Ren麻仁 NACannabis sativa