Target Description
| Type | Detail |
|---|---|
| Target ID | T27IAF |
| Protein Name | Lactoylglutathione lyase |
| Uniprot ID |
Q04760 |
| Protein Name Alias | EC 4.4.1.5; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase |
| Gene ID |
2739 |
| Gene Symbol | GLO1 |
| Gene Alias | NA |
| TTD | T88285: Clinical Trial target |
| Pfam | PF00903 |
| GO |
0008270:zinc ion binding
0005737:cytoplasm 0006357:regulation of transcription by RNA polymerase II 0070062:extracellular exosome 0009438:methylglyoxal metabolic process 0004462:lactoylglutathione lyase activity 0030316:osteoclast differentiation 0006090:pyruvate metabolic process 0005654:nucleoplasm 0005975:carbohydrate metabolic process 0005829:cytosol 0043066:negative regulation of apoptotic process 0006749:glutathione metabolic process 0005886:plasma membrane |
| PDB | 1FRO ; 3VW9 ; 1QIP ; 1BH5 ; 3W0U ; 1QIN ; 3W0T |
| Drugbank | DB03130 ; DB00143 ; DB03602 ; DB08179 ; DB00328 ; DB04132 ; DB03330 ; DB03345 |
| KEGG | hsa:2739 |
Related Compounds (Total: 6)
C0213
Name: Metformin
C0243
Name: Naringin
C0347
Name: Pyridoxamine
C0363
Name: Resveratrol
C0566
Name: Hesperitin
Related Herbs (Total: 76)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0652 | Xiang Yuan Pi | 香橼皮 | Wilson citron | Citrus medica |
| H1213 | Hu Zhang | 虎杖 | Japanese fleeceflower | Polygonum cuspidatum |
| H1225 | Huai Mi | 槐米 | NA | Sophora japonica |
| H0416 | Shan Shen | 山参 | NA | Panax ginseng |
| H0088 | Ju He | 橘核 | Tangerine seed | Citrus reticulata |
| H0269 | Mu Gua | 木瓜 | Chinese floweringquince | Chaenomeles sinensis |
| H1227 | Huai Zhi | 槐枝 | NA | Sophora japonica |
| H1250 | Huang Qi Ti Qu Ye | 黄芪提取液 | Membranous milkvetch | Astragalus membranaceus |
| H0693 | Xue Xie | 血蝎 | Dragon's blood | Daemonorops draco |
| H0651 | Xiang Yuan | 香橼 | Wilson citron | Citrus medica |
| H0226 | Man Yue Mei | 蔓越莓 | Cranberry | Vaccinium oxycoccos |
| H0472 | Shu Da Huang | 熟大黄 | NA | Rheum palmatum |
| H0926 | Da Huang | 大黄 | Medicinal rhubarb | Rheum officinale |
| H0604 | Wu Wei Teng | 五味藤 | NA | Securidaca inappendiculata |
| H0602 | Wu Mei Rou | 乌梅肉 | Ebony | Prunus mume |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H1217 | Bai Mei Hua | 白梅花 | Japanese apricot flower | Prunus mume |
| H0052 | Jin Ju | 金橘 | Oval kumquat | Fortunella margarita |
| H0626 | Xi Nan Huang Qin | 西南黄芩 | Yunnan skullcap | Scutellaria amoena |
| H0883 | Chuan She Gan | 川射干 | Blackberrylily | Belamcanda chinensis |
| H0927 | Da Huang Jin Gao | 大黄浸膏 | Medicinal rhubarb | Rheum officinale |
| H0758 | Cheng Pi | 橙皮 | Bitter orange | Citrus aurantium |
| H0932 | Ba Qia | 菝葜 | Chinaroot greenbrier | Smilax china |
| H1166 | He Shou Wu | 何首乌 | Tuber fleeceflower | Polygonum multiflorum |
| H0195 | Ma Chi Xian | 马齿苋 | Purslane | Portulaca oleracea |
| H1247 | Huang Qi | 黄芪 | Membranous milkvetch | Astragalus membranaceus |
| H0570 | Tu Fu Ling | 土茯苓 | Glabrous greenbrier | Smilax glabra |
| H0765 | Chi Dou | 赤豆 | Assuki bean | Vigna angularis |
| H0142 | Liang Jiang | 良姜 | NA | Alpinia officinarum |
| H0434 | She Pu Tao | 蛇葡萄 | Ampelopsis | Ampelopsis brevipedunculata |
| H0976 | Di Qing Pi | 地青皮 | NA | Pericarpium citri reticulatae viride |
| H0152 | Ling Zhi Jin Gao | 灵芝浸膏 | NA | Ganoderma lucidum |
| H1102 | Gu Sui Bu | 骨碎补 | Fortune’s drynaria rhizome | Drynaria fortunei |
| H0938 | Da Suan | 大蒜 | Garlic | Allium sativum |
| H0644 | Xiang Mao | 香茅 | Lemongrass | Cymbopogon citratus |
| H0928 | Da Huang Liu Jin Gao | 大黄流浸膏 | Medicinal rhubarb | Rheum officinale |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H0719 | Chen Pi | 陈皮 | Dried tangerine peel | Pericarpium citri reticulatae |
| H1222 | Huai Hua | 槐花 | flower bud of japanese pagodatree | Sophora japonica |
| H0270 | Mu Hu Die | 木蝴蝶 | Indian trumpetflower | Oroxylum indicum |
| H0091 | Ju Hong Pi | 橘红皮 | Red tangerine peel | Exocarpium citri rubrum |
| H0153 | Ling Zhi(1) | 灵芝 | Lucid ganoderma | Ganoderma lucidum |
| H0432 | She Gan | 射干 | Blackberrylily | Belamcanda chinensis |
| H0556 | Tie Xian Cao | 铁线草 | NA | Adiantum capillus-veneris |
| H1093 | Gao Liang Jiang You | 高良姜油 | Lesser galangal | Alpinia officinarum |
| H0895 | Chuan Yu Jin | 川郁金 | Turmeric | Curcuma longa |
| H1224 | Huai Jiao | 槐角 | pod of japanese pagodatree | Sophora japonica |
| H0358 | Ren Shen Ye | 人参叶 | Ginseng leaf | Panax ginseng |
| H0130 | Lei Gong Teng | 雷公藤 | Common threewingnut | Tripterygium wilfordii |
| H1117 | Guan Zhong | 贯众 | Male fern rhizome | Dryopteris crassirhizoma |
| H0347 | Qing Pi | 青皮 | Green tangerine peel | Pericarpium citri reticulatae viride |
| H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
| H0667 | Xiao Qing Pi | 小青皮 | Green tangerine peel | Pericarpium citri reticulatae viride |
| H0617 | Qian Cao Teng | 茜草藤 | NA | Rubia cordifolia |
| H0802 | Zhi Geng | 枳梗 | NA | Citrus aurantium |
| H0093 | Ju Pi | 橘皮 | Tangerine pericarp | Citrus reticulata |
| H0089 | Ju Hong | 橘红 | NA | Citri exocarpium rubrum |
| H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
| H0192 | Lv Yi Zhi Shi | 绿衣枳实 | NA | Poncirus trifoliata |
| H0761 | Yu Jin | 郁金 | AromaticTurmeric | Curcuma aromatica |
| H0164 | Ban Zhi Lian | 半枝莲 | Barbed skullcap | Scutellaria barbata |
| H0467 | Shi Shang Bai | 石上柏 | Doederlein's spikemoss herb | Herba selaginellae doederleinii |
| H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
| H0028 | Jiang Huang | 姜黄 | Common turmeric | Curcuma longa |
| H0804 | Zhi Ke | 枳壳 | Seville ora nge unripe fruit | Citrus aurantium |
| H0324 | Qian Jin Ba | 千斤拔 | root of philippine flemingia | Radix moghaniae philippinensis |
| H0357 | Ren Shen | 人参 | Ginseng | Panax ginseng |
| H0046 | Jin Gan | 金柑 | Japanese kumquat | Fortunella japonica |
| H1249 | Huang Qi Jin Gao | 黄芪浸膏 | Membranous milkvetch | Astragalus membranaceus |
| H0601 | Wu Mei | 乌梅 | Japanese apricot | Prunus mume |
| H1092 | Gao Liang Jiang | 高良姜 | Lesser galangal | Alpinia officinarum |
| H1248 | Huang Qi Gan Jin Gao | 黄芪干浸膏 | Membranous milkvetch | Astragalus membranaceus |
| H0805 | Zhi Ke Gan Jin Gao | 枳壳干浸膏 | Seville ora nge unripe fruit | Citrus aurantium |
| H0219 | Man Shan Hong | 满山红 | Dahurian rhododendron | Rhododendron dauricum |
| H1215 | Hua Ju Hong | 化橘红 | Pummelo peel | Exocarpium citri grandis |
| H0813 | Zhi Shi | 枳实 | Seville orange young fruit | Citrus aurantium |