Compound Description
| ID: C0243 | Common name: Naringin |
| IUPAC: (2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one | CAS: CAS:10236-47-2 |
| Chembl ID: CHEMBL451532 | Pubchem ID: CID:442428 |
| Formula: C27H32O14 | TCM-ID: TCMC1735 |
| Smiles: CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(C=C5)O)O)CO)O)O)O)O)O | |
| Alias:
4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (S)-;
Naringin; (2S)-7-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; (2S)-Naringin; 7-[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyloxy]-2,3-dihydro-4',5,7-trihydroxyflavone; Aurantiin; K-ALL; KTB 30983; NSC 5548; Naringenin 7-O-neohesperidoside; Naringenin 7-neohesperidoside; Naringenin 7-β-neohesperidoside; Naringoside |
Structure:
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Related Targets (Total: 24)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T57L0X | Oxysterols receptor LXR-alpha | NR1H3 |
Q13133 |
A | 1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
A | 1 Reference(s) |
| T25Y64 | Cholinesterase | BCHE |
P06276 |
A | 1 Reference(s) |
| T45G32 | Proto-oncogene tyrosine-protein kinase Src | SRC |
P12931 |
A | 2 Reference(s) |
| T27IAF | Lactoylglutathione lyase | GLO1 |
Q04760 |
A | 1 Reference(s) |
| T95A04 | Solute carrier organic anion transporter family member 2B1 | SLCO2B1 |
O94956 |
A | 1 Reference(s) |
| T98RXH | Focal adhesion kinase 1 | PTK2 |
Q05397 |
A | 1 Reference(s) |
| T31YO2 | Solute carrier organic anion transporter family member 1A2 | SLCO1A2 |
P46721 |
A | 1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
A | 1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
A | 2 Reference(s) |
| T92UWJ | Beta-2 adrenergic receptor | ADRB2 |
P07550 |
A | 1 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
A | 1 Reference(s) |
| T31SX8 | Bone morphogenetic protein 2 | BMP2 |
P12643 |
B | 1 Reference(s) |
| T00OVG | Semaphorin-3A | SEMA3A |
Q14563 |
C | 1 Reference(s) |
| T67HXL | Glial cell line-derived neurotrophic factor | GDNF |
P39905 |
C | 1 Reference(s) |
| T09BRP | NA | PKB_RS07820 |
NA |
C | 1 Reference(s) |
| T50DXZ | NA | MIR126 |
NA |
C | 1 Reference(s) |
| T53KY7 | Cystic fibrosis transmembrane conductance regulator | CFTR |
P13569 |
C | 1 Reference(s) |
| T28RI5 | Zinc finger E-box-binding homeobox 1 | ZEB1 |
P37275 |
C | 1 Reference(s) |
| T75NEV | Aquaporin-1 | AQP1 |
P29972 |
C | 1 Reference(s) |
| T30AEN | Aquaporin-5 | AQP5 |
P55064 |
C | 1 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
C | 1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
C | 1 Reference(s) |
| T16UHV | Nuclear factor of activated T-cells, cytoplasmic 1 | NFATC1 |
O95644 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 48)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H1248 | Huang Qi Gan Jin Gao | 黄芪干浸膏 | Membranous milkvetch | Astragalus membranaceus |
| H1227 | Huai Zhi | 槐枝 | NA | Sophora japonica |
| H0195 | Ma Chi Xian | 马齿苋 | Purslane | Portulaca oleracea |
| H1102 | Gu Sui Bu | 骨碎补 | Fortune’s drynaria rhizome | Drynaria fortunei |
| H0472 | Shu Da Huang | 熟大黄 | NA | Rheum palmatum |
| H0093 | Ju Pi | 橘皮 | Tangerine pericarp | Citrus reticulata |
| H0644 | Xiang Mao | 香茅 | Lemongrass | Cymbopogon citratus |
| H0091 | Ju Hong Pi | 橘红皮 | Red tangerine peel | Exocarpium citri rubrum |
| H0926 | Da Huang | 大黄 | Medicinal rhubarb | Rheum officinale |
| H1217 | Bai Mei Hua | 白梅花 | Japanese apricot flower | Prunus mume |
| H0164 | Ban Zhi Lian | 半枝莲 | Barbed skullcap | Scutellaria barbata |
| H0927 | Da Huang Jin Gao | 大黄浸膏 | Medicinal rhubarb | Rheum officinale |
| H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
| H0467 | Shi Shang Bai | 石上柏 | Doederlein's spikemoss herb | Herba selaginellae doederleinii |
| H0802 | Zhi Geng | 枳梗 | NA | Citrus aurantium |
| H1215 | Hua Ju Hong | 化橘红 | Pummelo peel | Exocarpium citri grandis |
| H0667 | Xiao Qing Pi | 小青皮 | Green tangerine peel | Pericarpium citri reticulatae viride |
| H0152 | Ling Zhi Jin Gao | 灵芝浸膏 | NA | Ganoderma lucidum |
| H0324 | Qian Jin Ba | 千斤拔 | root of philippine flemingia | Radix moghaniae philippinensis |
| H0804 | Zhi Ke | 枳壳 | Seville ora nge unripe fruit | Citrus aurantium |
| H0805 | Zhi Ke Gan Jin Gao | 枳壳干浸膏 | Seville ora nge unripe fruit | Citrus aurantium |
| H0052 | Jin Ju | 金橘 | Oval kumquat | Fortunella margarita |
| H0758 | Cheng Pi | 橙皮 | Bitter orange | Citrus aurantium |
| H0088 | Ju He | 橘核 | Tangerine seed | Citrus reticulata |
| H0130 | Lei Gong Teng | 雷公藤 | Common threewingnut | Tripterygium wilfordii |
| H0602 | Wu Mei Rou | 乌梅肉 | Ebony | Prunus mume |
| H1250 | Huang Qi Ti Qu Ye | 黄芪提取液 | Membranous milkvetch | Astragalus membranaceus |
| H0928 | Da Huang Liu Jin Gao | 大黄流浸膏 | Medicinal rhubarb | Rheum officinale |
| H0046 | Jin Gan | 金柑 | Japanese kumquat | Fortunella japonica |
| H0813 | Zhi Shi | 枳实 | Seville orange young fruit | Citrus aurantium |
| H0976 | Di Qing Pi | 地青皮 | NA | Pericarpium citri reticulatae viride |
| H1224 | Huai Jiao | 槐角 | pod of japanese pagodatree | Sophora japonica |
| H0601 | Wu Mei | 乌梅 | Japanese apricot | Prunus mume |
| H1222 | Huai Hua | 槐花 | flower bud of japanese pagodatree | Sophora japonica |
| H0192 | Lv Yi Zhi Shi | 绿衣枳实 | NA | Poncirus trifoliata |
| H0153 | Ling Zhi(1) | 灵芝 | Lucid ganoderma | Ganoderma lucidum |
| H1249 | Huang Qi Jin Gao | 黄芪浸膏 | Membranous milkvetch | Astragalus membranaceus |
| H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
| H0651 | Xiang Yuan | 香橼 | Wilson citron | Citrus medica |
| H0089 | Ju Hong | 橘红 | NA | Citri exocarpium rubrum |
| H0219 | Man Shan Hong | 满山红 | Dahurian rhododendron | Rhododendron dauricum |
| H1247 | Huang Qi | 黄芪 | Membranous milkvetch | Astragalus membranaceus |
| H1225 | Huai Mi | 槐米 | NA | Sophora japonica |
| H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
| H0719 | Chen Pi | 陈皮 | Dried tangerine peel | Pericarpium citri reticulatae |
| H0652 | Xiang Yuan Pi | 香橼皮 | Wilson citron | Citrus medica |
| H0347 | Qing Pi | 青皮 | Green tangerine peel | Pericarpium citri reticulatae viride |
| H0604 | Wu Wei Teng | 五味藤 | NA | Securidaca inappendiculata |
Ckey description of the interaction between compound and target