HIT-result

Target Description

Type	Detail
Target ID	T13YN2
Protein Name	Bcl-2-like protein 1
Uniprot ID	Q64373
Protein Name Alias	Bcl2-L-1; Apoptosis regulator Bcl-X
Gene ID	12048
Gene Symbol	Bcl2l1
Gene Alias	Bcl2l; Bclx
TTD	NA
Pfam	PF02180 ; PF00452
GO	0097192:extrinsic apoptotic signaling pathway in absence of ligand 0046898:response to cycloheximide 0005740:mitochondrial envelope 1902042:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 0008630:intrinsic apoptotic signaling pathway in response to DNA damage 0051881:regulation of mitochondrial membrane potential 1900244:positive regulation of synaptic vesicle endocytosis 0031965:nuclear membrane 0097136:Bcl-2 family protein complex 0005743:mitochondrial inner membrane 0044877:protein-containing complex binding 0001836:release of cytochrome c from mitochondria 0009615:response to virus 0008284:positive regulation of cell population proliferation 0051020:GTPase binding 0051402:neuron apoptotic process 0002931:response to ischemia 0070584:mitochondrion morphogenesis 0043066:negative regulation of apoptotic process 0009566:fertilization 0007283:spermatogenesis 0071312:cellular response to alkaloid 2000809:positive regulation of synaptic vesicle clustering 0001541:ovarian follicle development 0046902:regulation of mitochondrial membrane permeability 0071230:cellular response to amino acid stimulus 1903077:negative regulation of protein localization to plasma membrane 0007281:germ cell development 0008584:male gonad development 0040008:regulation of growth 0034097:response to cytokine 0051434:BH3 domain binding 0016020:membrane 0098793:presynapse 0005759:mitochondrial matrix 0008283:cell population proliferation 0071480:cellular response to gamma radiation 0030276:clathrin binding 0005829:cytosol 0051607:defense response to virus 0030672:synaptic vesicle membrane 1902236:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 2001171:positive regulation of ATP biosynthetic process 0036466:synaptic vesicle recycling via endosome 0097284:hepatocyte apoptotic process 0071839:apoptotic process in bone marrow cell 0019050:suppression by virus of host apoptotic process 0043524:negative regulation of neuron apoptotic process 1900118:negative regulation of execution phase of apoptosis 0097371:MDM2/MDM4 family protein binding 0001701:in utero embryonic development 0043065:positive regulation of apoptotic process 2000302:positive regulation of synaptic vesicle exocytosis 0005813:centrosome 2000811:negative regulation of anoikis 0051400:BH domain binding 0046982:protein heterodimerization activity 0007093:mitotic cell cycle checkpoint 0042981:regulation of apoptotic process 0042803:protein homodimerization activity 1900452:regulation of long-term synaptic depression 2001243:negative regulation of intrinsic apoptotic signaling pathway 0009314:response to radiation 0005741:mitochondrial outer membrane 0042802:identical protein binding 0016021:integral component of membrane 1902230:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage 0043027:cysteine-type endopeptidase inhibitor activity involved in apoptotic process 0019901:protein kinase binding 0005783:endoplasmic reticulum 0005737:cytoplasm 0031966:mitochondrial membrane 0005739:mitochondrion 0008134:transcription factor binding 0032465:regulation of cytokinesis
PDB	4YK9 ; 5C3G ; 4YJ4 ; 1PQ0 ; 3IHD ; 3ILC ; 3IHE ; 3IHF ; 3IIH ; 1PQ1 ; 3IHC ; 3ILB ; 3IIG ; 2BZW
Drugbank	NA
KEGG	mmu:12048

Type

Detail

Target ID

T13YN2

Protein Name

Bcl-2-like protein 1

Uniprot ID

Q64373

Protein Name Alias

Bcl2-L-1; Apoptosis regulator Bcl-X

Gene ID

12048

Gene Symbol

Bcl2l1

Gene Alias

Bcl2l; Bclx

TTD

Pfam

PF02180 ; PF00452

0097192:extrinsic apoptotic signaling pathway in absence of ligand

0046898:response to cycloheximide

0005740:mitochondrial envelope

1902042:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

0008630:intrinsic apoptotic signaling pathway in response to DNA damage

0051881:regulation of mitochondrial membrane potential

1900244:positive regulation of synaptic vesicle endocytosis

0031965:nuclear membrane

0097136:Bcl-2 family protein complex

0005743:mitochondrial inner membrane

0044877:protein-containing complex binding

0001836:release of cytochrome c from mitochondria

0009615:response to virus

0008284:positive regulation of cell population proliferation

0051020:GTPase binding

0051402:neuron apoptotic process

0002931:response to ischemia

0070584:mitochondrion morphogenesis

0043066:negative regulation of apoptotic process

0009566:fertilization

0007283:spermatogenesis

0071312:cellular response to alkaloid

2000809:positive regulation of synaptic vesicle clustering

0001541:ovarian follicle development

0046902:regulation of mitochondrial membrane permeability

0071230:cellular response to amino acid stimulus

1903077:negative regulation of protein localization to plasma membrane

0007281:germ cell development

0008584:male gonad development

0040008:regulation of growth

0034097:response to cytokine

0051434:BH3 domain binding

0016020:membrane

0098793:presynapse

0005759:mitochondrial matrix

0008283:cell population proliferation

0071480:cellular response to gamma radiation

0030276:clathrin binding

0005829:cytosol

0051607:defense response to virus

0030672:synaptic vesicle membrane

1902236:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

2001171:positive regulation of ATP biosynthetic process

0036466:synaptic vesicle recycling via endosome

0097284:hepatocyte apoptotic process

0071839:apoptotic process in bone marrow cell

0019050:suppression by virus of host apoptotic process

0043524:negative regulation of neuron apoptotic process

1900118:negative regulation of execution phase of apoptosis

0097371:MDM2/MDM4 family protein binding

0001701:in utero embryonic development

0043065:positive regulation of apoptotic process

2000302:positive regulation of synaptic vesicle exocytosis

0005813:centrosome

2000811:negative regulation of anoikis

0051400:BH domain binding

0046982:protein heterodimerization activity

0007093:mitotic cell cycle checkpoint

0042981:regulation of apoptotic process

0042803:protein homodimerization activity

1900452:regulation of long-term synaptic depression

2001243:negative regulation of intrinsic apoptotic signaling pathway

0009314:response to radiation

0005741:mitochondrial outer membrane

0042802:identical protein binding

0016021:integral component of membrane

1902230:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

0043027:cysteine-type endopeptidase inhibitor activity involved in apoptotic process

0019901:protein kinase binding

0005783:endoplasmic reticulum

0005737:cytoplasm

0031966:mitochondrial membrane

0005739:mitochondrion

0008134:transcription factor binding

0032465:regulation of cytokinesis

PDB

4YK9 ; 5C3G ; 4YJ4 ; 1PQ0 ; 3IHD ; 3ILC ; 3IHE ; 3IHF ; 3IIH ; 1PQ1 ; 3IHC ; 3ILB ; 3IIG ; 2BZW

Drugbank

KEGG

mmu:12048

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H0863	Zui Xian Tao	醉仙桃	jimsonweed	Datura stramonium
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H0223	Man Tuo Luo Jin Gao	曼陀罗浸膏	Jimsonweed	Datura stramonium
H0683	Xiu Xian Ju	绣线菊	Japanese spiraea	Spiraea japonica
H0253	Mian Hua Gen	棉花根	Levant cotton root	Gossypium herbaceum
H1041	Feng Qie Hua	枫茄花	Jimsonweed	Datura stramonium
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0669	Xie Bai	薤白	Longstamen onion	Allium macrostemon
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0222	Man Tuo Luo	曼陀罗	Jimsonweed	Datura stramonium
H0468	Shi Wei	石韦	Japanese felt fern frond	Pyrrosia lingua
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H0416	Shan Shen	山参	NA	Panax ginseng
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa

Target Description

Related Compounds (Total: 10)

Related Herbs (Total: 23)