Compound Description

ID:   C0112 Common name:   Gossypol
IUPAC:  7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde CAS:  CAS:303-45-7
Chembl ID:   CHEMBL51483 Pubchem ID:   CID:3503
Formula:  C30H30O8 TCM-ID:  TCMC1287
Smiles:  CC1=CC2=C(C(=C(C(=C2C(C)C)O)O)C=O)C(=C1C3=C(C4=C(C=C3C)C(=C(C(=C4C=O)O)O)C(C)C)O)O
Alias:

[2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-;

1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)[2,2'-binaphthalene]-8,8'-dicarboxaldehyde;

(±)-Gossypol;

1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-diisopropyl-2,2'-binaphthyl-8,8'-dialdehyde;

1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-diisopropyl[2,2'-binaphthalene]-8,8'-dicarboxaldehyde;

1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'-binaphthalene-8,8'-dicarboxaldehyde;

1,6,7,1',6',7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2']binaphthalenyl-8,8'-dicarboxaldehyde;

2,2'-Bis[1,6,7-trihydroxy-3-methyl-5-isopropyl-8-aldehydonaphthyl];

2,2'-Bis[8-formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthyl];

BL 193;

Gossypol;

NSC 56817;

NSC 624336;

No Fertil;

Pogosin;

Tash 1
Structure:

Related Targets  (Total: 16)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
A 6 Reference(s)
T23WX7 Nuclear receptor coactivator 1NCOA1 Q15788
A 1 Reference(s)
T08KTR Nuclear receptor coactivator 3NCOA3 Q9Y6Q9
A 2 Reference(s)
T74I49 Bcl-2-like protein 1BCL2L1 Q07817
A 6 Reference(s)
T39M81 DNA-(apurinic or apyrimidinic site) endonucleaseAPEX1 P27695
A 1 Reference(s)
T10HL8 Intercellular adhesion molecule 1ICAM1 P05362
A 1 Reference(s)
T55Z0P L-lactate dehydrogenase A chainLDHA P00338
A 2 Reference(s)
T77DWZ PCNA-associated factorPCLAF Q15004
A 1 Reference(s)
T40DIM Corticosteroid 11-beta-dehydrogenase isozyme 1HSD11B1 P28845
A 1 Reference(s)
T38T1U Caspase-8CASP8 Q14790
B 1 Reference(s)
T85U8U Caspase-3CASP3 P42574
B 1 Reference(s)
T54CIF Interleukin-8CXCL8 P10145
B 1 Reference(s)
T23P74 Caspase-9CASP9 P55211
B 1 Reference(s)
T76B0A Gap junction alpha-1 proteinGJA1 P17302
B 1 Reference(s)
T14JSX PlasminogenPLG P00747
B 1 Reference(s)
T13YN2 Bcl-2-like protein 1Bcl2l1 Q64373
B 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 1)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0253 Mian Hua Gen棉花根 Levant cotton rootGossypium herbaceum