Target Description

Type Detail
Target ID T75IW3
Protein Name Matrix metalloproteinase-14
Uniprot ID P50281
Protein Name Alias MMP-14;  EC 3.4.24.80;  MMP-X1;  Membrane-type matrix metalloproteinase 1;  MT-MMP 1;  MTMMP1;  Membrane-type-1 matrix metalloproteinase;  MT1-MMP;  MT1MMP
Gene ID 4323
Gene Symbol MMP14
Gene Alias NA
TTD T65019: Clinical Trial target
Pfam PF00045 ; PF00413 ; PF11857 ; PF01471
GO
0005178:integrin binding

0045111:intermediate filament cytoskeleton

0031012:extracellular matrix

0005796:Golgi lumen

0060322:head development

0005615:extracellular space

0048701:embryonic cranial skeleton morphogenesis

1905523:positive regulation of macrophage migration

0051895:negative regulation of focal adhesion assembly

0001666:response to hypoxia

0031410:cytoplasmic vesicle

0044354:macropinosome

0043627:response to estrogen

0004222:metalloendopeptidase activity

1990834:response to odorant

0035987:endodermal cell differentiation

0001935:endothelial cell proliferation

0005925:focal adhesion

0001525:angiogenesis

0031638:zymogen activation

0005829:cytosol

0030574:collagen catabolic process

0001958:endochondral ossification

0001501:skeletal system development

0030307:positive regulation of cell growth

0035988:chondrocyte proliferation

0016485:protein processing

0005886:plasma membrane

0006508:proteolysis

0097094:craniofacial suture morphogenesis

1903076:regulation of protein localization to plasma membrane

0005887:integral component of plasma membrane

0022617:extracellular matrix disassembly

0030324:lung development

0045746:negative regulation of Notch signaling pathway

0045579:positive regulation of B cell differentiation

0008270:zinc ion binding

0014070:response to organic cyclic compound

0048754:branching morphogenesis of an epithelial tube

0030335:positive regulation of cell migration

0042470:melanosome

0001541:ovarian follicle development

0010831:positive regulation of myotube differentiation

0043615:astrocyte cell migration

0005634:nucleus

0009612:response to mechanical stimulus

0004175:endopeptidase activity

0008584:male gonad development

0048771:tissue remodeling

0030198:extracellular matrix organization

0048870:cell motility

0010954:positive regulation of protein processing

0006979:response to oxidative stress

0070006:metalloaminopeptidase activity

PDB 3X23 ; 5H0U ; 1BQQ ; 4P3D ; 6CM1 ; 3MA2 ; 1BUV ; 2MQS ; 4P3C ; 6CLZ ; 4QXU ; 3C7X
Drugbank DB00786
KEGG hsa:4323

Related Compounds  (Total: 5)

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C0325
Name: Progesterone
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C0532
Name: Procyanidin B2
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C0739
Name: (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione
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C1113
Name: heparin
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C1265
Name: Curcumin


Related Herbs  (Total: 56)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0478 Shu Lang薯莨 NADioscorea cirrhosa
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H0788 Zhang Nao Zi樟脑子 CamphorarCinnamomum camphora
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H1212 Hu Ye Gan Jin Gao槲叶干浸膏 NAQuercus dentata
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H0368 Rou Gui Zi肉桂子 CassiabarktreeCinnamomum cassia
H1099 Gou Teng钩藤 Sharpleaf gambirplantUncaria rhynchophylla
H0142 Liang Jiang良姜 NAAlpinia officinarum
H0925 Da Fu Zi大腹子 Areca palmAreca catechu
H0519 Suo Yang锁阳 Songaria cynomoriumCynomorium songaricum
H0366 Rou Gui肉桂 CassiabarktreeCinnamomum cassia
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H0370 Ru Xiang乳香 OlibanumBoswellia carterii
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H0790 Zhang Shu Zi樟树子 Camphor treeCinnamomum camphora
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0615 Wu Zhi Mao Tao五指毛桃 five-finger fig rootFicus simplicissima
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0789 Zhang Shu Gen樟树根 Camphor treeCinnamomum camphora
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H1114 Guan Gui官桂 CassiabarktreeCinnamomum cassia
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0056 Jin Qiao Mai金荞麦 Wild buckwheat rhizomeRhizoma fagopyri cymosi
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0181 Luo Bu Ma罗布麻 DogbaneApocynum venetum
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0967 Di Er Cao地耳草 Japanese stJohn’swortHypericum japonicum
H1137 Gui Yuan桂圆 NADimocarpus longan
H0786 Zhang Mu樟木 Ligum cinmamomi camphoraeCinnamomum camphora
H1139 Gui Zhi桂枝 Cassiabarktree twigCinnamomum cassia
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0787 Zhang Nao樟脑 CamphorarCinnamomum camphora
H0308 Pi Ba Ren枇杷仁 NAEriobotrya japonica
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0120 Ban Bian Qi半边旗 pinnated brake herbPteris semipinnata
H0764 Yu Xing Cao鱼腥草 Heartleaf houttuyniaHouttuynia cordata
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H0408 Bing Lang槟榔 BetenutpalmAreca catechu
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida