Target Description

Type Detail
Target ID T28K6X
Protein Name Insulin receptor substrate 1
Uniprot ID P35568
Protein Name Alias IRS-1
Gene ID 3667
Gene Symbol IRS1
Gene Alias NA
TTD T15510: Clinical Trial target
Pfam PF02174 ; PF00169
GO
0008286:insulin receptor signaling pathway

0000165:MAPK cascade

0030159:signaling receptor complex adaptor activity

0038111:interleukin-7-mediated signaling pathway

0045725:positive regulation of glycogen biosynthetic process

0005068:transmembrane receptor protein tyrosine kinase adaptor activity

0048009:insulin-like growth factor receptor signaling pathway

0046627:negative regulation of insulin receptor signaling pathway

0005080:protein kinase C binding

0005829:cytosol

0043434:response to peptide hormone

0005901:caveola

0043552:positive regulation of phosphatidylinositol 3-kinase activity

0042169:SH2 domain binding

0046676:negative regulation of insulin secretion

0043548:phosphatidylinositol 3-kinase binding

0005886:plasma membrane

0042593:glucose homeostasis

0001784:phosphotyrosine residue binding

0005654:nucleoplasm

0032868:response to insulin

0005899:insulin receptor complex

0010907:positive regulation of glucose metabolic process

0005737:cytoplasm

0046628:positive regulation of insulin receptor signaling pathway

0032869:cellular response to insulin stimulus

0014065:phosphatidylinositol 3-kinase signaling

0048015:phosphatidylinositol-mediated signaling

0005634:nucleus

0008284:positive regulation of cell population proliferation

0046326:positive regulation of glucose import

0005158:insulin receptor binding

0005159:insulin-like growth factor receptor binding

0032000:positive regulation of fatty acid beta-oxidation

0043231:intracellular membrane-bounded organelle

0007165:signal transduction

0051897:positive regulation of protein kinase B signaling

0071398:cellular response to fatty acid

PDB 2Z8C ; 1QQG ; 6BNT ; 1IRS ; 1K3A ; 5U1M
Drugbank DB08513
KEGG hsa:3667

Related Compounds  (Total: 9)

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C0045
Name: Epicatechin Gallate
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C0055
Name: Estradiol
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C0210
Name: Melatonin
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C0363
Name: Resveratrol
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C0436
Name: Testosterone


Related Herbs  (Total: 113)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H1061 Bai He百合 LilyLilium brownii
H0357 Ren Shen人参 GinsengPanax ginseng
H0818 Zhi Zi栀子 Cape jasmine fruitGardenia jasminoides
H1102 Gu Sui Bu骨碎补 Fortune’s drynaria rhizomeDrynaria fortunei
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H0236 Mao She Xiang Jin Gao毛麝香浸膏 AbelmuskMoschus moschiferus
H0424 Shan Zhi山栀 Cape jasmineGardenia jasminoides
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0029 Jiang Huang Lian姜黄连 Coptis deltoideaCoptis chinensis
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0356 Ren Gong She Xiang人工麝香 AbelmuskMoschus moschiferus
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H0142 Liang Jiang良姜 NAAlpinia officinarum
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H1068 Bai He Liu Jin Gao百合流浸膏 LilyLilium brownii
H1029 Fang Er Cha方儿茶 khair in hindiSenegalia catechu
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H0520 Tai Pan Fen胎盘粉 Fetus powderHuman placenta
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0998 Dong Gua Pi冬瓜皮 Chinese waxgourd peelBenincasa hispida
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0540 Tian Ji Huang田基黄 all - grass of japanese st. johnswortGrangea maderaspatana
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0437 She Xiang麝香 AbelmuskMoschus moschiferus
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H0368 Rou Gui Zi肉桂子 CassiabarktreeCinnamomum cassia
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0785 Ze Xi Huang Lian择细黄连 Coptis deltoideaCoptis chinensis
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H0652 Xiang Yuan Pi香橼皮 Wilson citronCitrus medica
H0519 Suo Yang锁阳 Songaria cynomoriumCynomorium songaricum
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H1231 Huang Bai Tan黄柏炭 Amur corktreePhellodendron amurense
H0077 Jiu EthanolVinum
H0366 Rou Gui肉桂 CassiabarktreeCinnamomum cassia
H0661 Xiao Hei Dou小黑豆 Black turtle beanPhaseolus vulgaris
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H1242 Huang Lian Gan Jin Gao黄连干浸膏 Coptis deltoideaCoptis chinensis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0706 Yan Hu Suo延胡索 YanhusuoCorydalis yanhusuo
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0819 Zhi Zi Jin Gao栀子浸膏 Cape jasmine fruitGardenia jasminoides
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0827 Zhu Hong Jun竹红菌 Bambusa hypocrella*Hypocrella bambusae
H0760 Yu Huang Lian萸黄连 Coptis deltoideaCoptis chinensis
H0682 Xiong Huang Lian雄黄连 Coptis deltoideaCoptis chinensis
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0872 Chuan Huang Lian川黄连 rhizome of chinese goldthreadCoptis chinensis
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H1243 Huang Lian Xu黄连须 Coptis deltoideaCoptis chinensis
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H1000 Dong Gua Zi冬瓜子 Chinese waxgourd seedBenincasa hispida
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H1241 Huang Lian黄连 Coptis deltoideaCoptis chinensis
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0082 Jiu Huang Lian酒黄连 Coptis deltoideaCoptis chinensis
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1115 Guan Huang Bai关黄柏 Amur cork treePhellodendron amurense
H0006 Bai Qu Cai白屈菜 Greater celandineChelidonium majus
H1230 Huang Bai Fen黄柏粉 Amur corktreePhellodendron amurense
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H1114 Guan Gui官桂 CassiabarktreeCinnamomum cassia
H0235 Mao She Xiang毛麝香 AbelmuskMoschus moschiferus
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H1004 Bai Cha白茶 White teaCamellia sinensis
H0521 Tai Pan Zu Zhi Fen胎盘组织粉 NAHuman placenta
H0651 Xiang Yuan香橼 Wilson citronCitrus medica
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H0704 Yan Guan Huang Bai盐关黄柏 Amur cork treePhellodendron amurense
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1139 Gui Zhi桂枝 Cassiabarktree twigCinnamomum cassia
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H1228 Huang Bai黄柏 Amur corktreePhellodendron amurense
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0416 Shan Shen山参 NAPanax ginseng
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H0633 Xia Tian Wu夏天无 Decumbent corydalisCorydalis decumbens