Compound Description

ID:   C0436 Common name:   Testosterone
IUPAC:  (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one CAS:  CAS:58-22-0
Chembl ID:   CHEMBL386630 Pubchem ID:   CID:6013
Formula:  C19H28O2 TCM-ID:  TCMC2142
Smiles:  O=C1CC[C@]2(C(=C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C)C
Alias:

Testosterone;

(17β)-17-Hydroxyandrost-4-en-3-one;

(+)-Testosterone;

(8R,9S,10R,13S,14S,17S)-17-Hydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one;

17β-Hydroxy-Δ4-androsten-3-one;

17β-Hydroxyandrost-4-en-3-one;

17β-Hydroxyandrost-4-ene-3-one;

17β-Testosterone;

4-Androsten-3-one-17β-ol;

AA 2500;

Andro 100;

AndroForte 5;

AndroGel;

Androderm;

Androlin;

Andronaq;

Andropatch;

Androst-4-en-17β-ol-3-one;

Androst-4-ene-17β-ol-3-one;

Andrusol;

Axiron;

CDB 111C;

COL 1621;

CP 601B;

Compleo;

Cristerona T;

Geno-cristaux Gremy;

Glowmin;

Homosteron;

Homosterone;

Intrinsa;

Mertestate;

NSC 9700;

Nasobol;

Natesto;

Neotestis;

Noseafix;

Opterone;

Oreton;

Orquisteron;

Perandren;

Percutacrine androgenique;

Primotest;

Primoteston;

Relibra;

Striant;

Synandrol F;

Teslen;

Testandrone;

Testiculosterone;

Testim;

Testobase;

Testoderm;

Testogel;

Testolent;

Testolin;

Testopatch;

Testopel;

Testopropon;

Testosteroid;

Testosteron;

Testoviron Schering;

Testoviron T;

Testro AQ;

Testrone;

Testryl;

Tostrelle;

Tostrex;

Viatrel;

Virormone;

Virosterone;

Δ4-Androsten-17β-ol-3-one
Structure:

Related Targets  (Total: 50)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
A 3 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
A 2 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
A 3 Reference(s)
T84Z2I SHC-transforming protein 1SHC1 P29353
A 2 Reference(s)
T62L0I Pro-FMRFamide-related neuropeptide VF [Cleaved into: Neuropeptide NPSF; Neuropeptide RFRP-1; Neuropeptide RFRP-2; Neuropeptide NPVFNPVF Q9HCQ7
A 1 Reference(s)
T60XJI Transient receptor potential cation channel subfamily M member 8TRPM8 Q7Z2W7
A 1 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
A 1 Reference(s)
T28PHS Angiotensin-converting enzymeACE P12821
A 1 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
A 1 Reference(s)
T57YL7 Sex hormone-binding globulinSHBG P04278
B 3 Reference(s)
T88LSZ AromataseCYP19A1 P11511
B 1 Reference(s)
T24PQ8 Oxoeicosanoid receptor 1OXER1 Q8TDS5
B 1 Reference(s)
T25BCC NADH-ubiquinone oxidoreductase chain 1MT-ND1 P03886
B 1 Reference(s)
T49NTM StAR-related lipid transfer protein 6STARD6 P59095
B 1 Reference(s)
T79CMV NADH-ubiquinone oxidoreductase chain 4MT-ND4 P03905
B 1 Reference(s)
T83H2N DNA damage-inducible transcript 4 proteinDDIT4 Q9NX09
B 1 Reference(s)
T85UJK Glycerophosphodiester phosphodiesterase 1GDE1 Q9NZC3
C 1 Reference(s)
T95M54 Programmed cell death protein 4PDCD4 Q53EL6
C 1 Reference(s)
T88B8X Insulin receptorINSR P06213
C 1 Reference(s)
T33OPP Interleukin-6IL6 P05231
C 2 Reference(s)
T32BH6 cGMP-specific 3',5'-cyclic phosphodiesterasePDE5A O76074
C 1 Reference(s)
T20JZ2 Androgen receptorAR P10275
C 2 Reference(s)
T89L4V InsulinINS P01308
C 1 Reference(s)
T58D39 OsteocalcinBGLAP P02818
C 1 Reference(s)
T77QFC Sterol 26-hydroxylase, mitochondrialCYP27A1 Q02318
C 1 Reference(s)
T85JI5 Vitamin D3 receptorVDR P11473
C 1 Reference(s)
T42HHN Follicle-stimulating hormone receptorFSHR P23945
C 1 Reference(s)
T80MG0 Growth hormone secretagogue receptor type 1GHSR Q92847
C 1 Reference(s)
T01QLH Estrogen receptorESR1 P03372
C 2 Reference(s)
T05O6O Estrogen receptor betaESR2 Q92731
C 1 Reference(s)
T49S5S Epididymal secretory glutathione peroxidaseGPX5 O75715
C 1 Reference(s)
T63BQU Cytochrome P450 1A1CYP1A1 P04798
C 1 Reference(s)
T51NKF Alpha-2-antiplasminSERPINF2 P08697
C 1 Reference(s)
T82P0Z ReninREN P00797
C 1 Reference(s)
T76B0A Gap junction alpha-1 proteinGJA1 P17302
C 1 Reference(s)
T28K6X Insulin receptor substrate 1IRS1 P35568
C 1 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
C 1 Reference(s)
T82VBE Hormone-sensitive lipaseLIPE Q05469
C 1 Reference(s)
T74QXI Serine/threonine-protein kinase mTORMTOR P42345
C 1 Reference(s)
T57A7G Diacylglycerol lipase-alphaDAGLA Q9Y4D2
C 1 Reference(s)
T69ZRP Appetite-regulating hormoneGHRL Q9UBU3
C 1 Reference(s)
T40IC2 Nucleobindin-2NUCB2 P80303
C 1 Reference(s)
T02QBS Cytochrome P450 1A2CYP1A2 P05177
C 1 Reference(s)
T30V3R 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1HSD3B1 P14060
C 1 Reference(s)
T04AHN 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2HSD3B2 P26439
C 1 Reference(s)
T54CIF Interleukin-8CXCL8 P10145
C 1 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
C 1 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
C 1 Reference(s)
T10ICM Oxidized low-density lipoprotein receptor 1OLR1 P78380
C 1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 4)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0847 Zi He Che紫河车 Human placentaHomo sapiens