HIT-result

Target Description

Type	Detail
Target ID	T84Z2I
Protein Name	SHC-transforming protein 1
Uniprot ID	P29353
Protein Name Alias	SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1
Gene ID	6464
Gene Symbol	SHC1
Gene Alias	SHC; SHCA
TTD	NA
Pfam	PF00017 ; PF00640
GO	0038128:ERBB2 signaling pathway 0070435:Shc-EGFR complex 0043410:positive regulation of MAPK cascade 0016525:negative regulation of angiogenesis 0038110:interleukin-2-mediated signaling pathway 0005168:neurotrophin TRKA receptor binding 0050900:leukocyte migration 0046875:ephrin receptor binding 0007169:transmembrane receptor protein tyrosine kinase signaling pathway 0008284:positive regulation of cell population proliferation 0045892:negative regulation of transcription, DNA-templated 0000187:activation of MAPK activity 0005543:phospholipid binding 0007176:regulation of epidermal growth factor-activated receptor activity 0005159:insulin-like growth factor receptor binding 0036498:IRE1-mediated unfolded protein response 0030971:receptor tyrosine kinase binding 0005759:mitochondrial matrix 0007507:heart development 0000165:MAPK cascade 0019901:protein kinase binding 0048408:epidermal growth factor binding 0005829:cytosol 0038095:Fc-epsilon receptor signaling pathway 0005158:insulin receptor binding 0046579:positive regulation of Ras protein signal transduction 0005886:plasma membrane 0001784:phosphotyrosine residue binding 0035723:interleukin-15-mediated signaling pathway 0007265:Ras protein signal transduction 0070374:positive regulation of ERK1 and ERK2 cascade 0008286:insulin receptor signaling pathway 0005068:transmembrane receptor protein tyrosine kinase adaptor activity 0071363:cellular response to growth factor stimulus 0007173:epidermal growth factor receptor signaling pathway 0045893:positive regulation of transcription, DNA-templated 0031532:actin cytoskeleton reorganization 0098609:cell-cell adhesion 0001525:angiogenesis 0016032:viral process 0005154:epidermal growth factor receptor binding 0019221:cytokine-mediated signaling pathway 0042742:defense response to bacterium 0007411:axon guidance 0040008:regulation of growth 0090322:regulation of superoxide metabolic process 0043066:negative regulation of apoptotic process 0071864:positive regulation of cell proliferation in bone marrow
PDB	1SHC ; 1OY2 ; 2L1C ; 6DM4 ; 4JMH ; 1TCE ; 5CZI ; 1N3H ; 1QG1 ; 4XWX ; 1MIL ; 1WCP
Drugbank	NA
KEGG	hsa:6464

Type

Detail

Target ID

T84Z2I

Protein Name

SHC-transforming protein 1

Uniprot ID

P29353

Protein Name Alias

SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1

Gene ID

6464

Gene Symbol

SHC1

Gene Alias

SHC; SHCA

TTD

Pfam

PF00017 ; PF00640

0038128:ERBB2 signaling pathway

0070435:Shc-EGFR complex

0043410:positive regulation of MAPK cascade

0016525:negative regulation of angiogenesis

0038110:interleukin-2-mediated signaling pathway

0005168:neurotrophin TRKA receptor binding

0050900:leukocyte migration

0046875:ephrin receptor binding

0007169:transmembrane receptor protein tyrosine kinase signaling pathway

0008284:positive regulation of cell population proliferation

0045892:negative regulation of transcription, DNA-templated

0000187:activation of MAPK activity

0005543:phospholipid binding

0007176:regulation of epidermal growth factor-activated receptor activity

0005159:insulin-like growth factor receptor binding

0036498:IRE1-mediated unfolded protein response

0030971:receptor tyrosine kinase binding

0005759:mitochondrial matrix

0007507:heart development

0000165:MAPK cascade

0019901:protein kinase binding

0048408:epidermal growth factor binding

0005829:cytosol

0038095:Fc-epsilon receptor signaling pathway

0005158:insulin receptor binding

0046579:positive regulation of Ras protein signal transduction

0005886:plasma membrane

0001784:phosphotyrosine residue binding

0035723:interleukin-15-mediated signaling pathway

0007265:Ras protein signal transduction

0070374:positive regulation of ERK1 and ERK2 cascade

0008286:insulin receptor signaling pathway

0005068:transmembrane receptor protein tyrosine kinase adaptor activity

0071363:cellular response to growth factor stimulus

0007173:epidermal growth factor receptor signaling pathway

0045893:positive regulation of transcription, DNA-templated

0031532:actin cytoskeleton reorganization

0098609:cell-cell adhesion

0001525:angiogenesis

0016032:viral process

0005154:epidermal growth factor receptor binding

0019221:cytokine-mediated signaling pathway

0042742:defense response to bacterium

0007411:axon guidance

0040008:regulation of growth

0090322:regulation of superoxide metabolic process

0043066:negative regulation of apoptotic process

0071864:positive regulation of cell proliferation in bone marrow

PDB

1SHC ; 1OY2 ; 2L1C ; 6DM4 ; 4JMH ; 1TCE ; 5CZI ; 1N3H ; 1QG1 ; 4XWX ; 1MIL ; 1WCP

Drugbank

KEGG

hsa:6464

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H1168	He Tao Ren	核桃仁	English walnut seed	Semen juglandis
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H1077	Bai Hu Jiao	白胡椒	white pepper	Piper nigrum
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H1176	Hei Hu Jiao	黑胡椒	Black pepper	Piper nigrum
H0888	Ba Dou Ye	巴豆叶	Pu rging croton	Croton tiglium
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0869	Ba Dou	巴豆	Pu rging croton	Croton tiglium
H1167	He Tao	核桃	English walnut seed	Semen juglandis
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H0582	Cao Dou Kou Ren	草豆蔻仁	Katsumada galangal	Alpinia katsumadai
H1133	Gui Jian Yu	鬼箭羽	Winged euonymus	Euonymus alatus
H1204	Hu Jiao	胡椒	Black pepper	Piper nigrum
H0574	Cao Dou Kou	草豆蔻	Katsumada galangal	Alpinia katsumadai
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0476	Can E	蚕蛾	Silkworm	Bombyx mori
H0878	Ba Dou Shuang	巴豆霜	Defatted croton seed powder	Croton tiglium

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 22)