HIT-result

Type	Detail
Target ID	T57FUN
Protein Name	Beclin-1
Uniprot ID	Q14457
Protein Name Alias	Coiled-coil myosin-like BCL2-interacting protein; Protein GT197
Gene ID	8678
Gene Symbol	BECN1
Gene Alias	GT197
TTD	T84616: Research target
Pfam	PF15285 ; PF04111 ; PF17675
GO	0042802:identical protein binding 0005634:nucleus 0007568:aging 0045022:early endosome to late endosome transport 0048666:neuron development 0034272:phosphatidylinositol 3-kinase complex, class III, type II 2001244:positive regulation of intrinsic apoptotic signaling pathway 0014068:positive regulation of phosphatidylinositol 3-kinase signaling 0030425:dendrite 0070301:cellular response to hydrogen peroxide 0051607:defense response to virus 0045335:phagocytic vesicle 2000378:negative regulation of reactive oxygen species metabolic process 0005789:endoplasmic reticulum membrane 0005829:cytosol 0045324:late endosome to vacuole transport 0010288:response to lead ion 0016236:macroautophagy 0051020:GTPase binding 0098780:response to mitochondrial depolarisation 0071364:cellular response to epidermal growth factor stimulus 0031625:ubiquitin protein ligase binding 0010040:response to iron(II) ion 0042149:cellular response to glucose starvation 0006915:apoptotic process 0060548:negative regulation of cell death 2000786:positive regulation of autophagosome assembly 0008285:negative regulation of cell population proliferation 0001666:response to hypoxia 0007040:lysosome organization 0007080:mitotic metaphase plate congression 1902425:positive regulation of attachment of mitotic spindle microtubules to kinetochore 0006995:cellular response to nitrogen starvation 0019901:protein kinase binding 0071275:cellular response to aluminum ion 1902902:negative regulation of autophagosome assembly 0032801:receptor catabolic process 0005776:autophagosome 0005783:endoplasmic reticulum 0006914:autophagy 0032465:regulation of cytokinesis 0034198:cellular response to amino acid starvation 0031966:mitochondrial membrane 0000422:autophagy of mitochondrion 0043066:negative regulation of apoptotic process 0042493:response to drug 0050790:regulation of catalytic activity 0043548:phosphatidylinositol 3-kinase binding 0006968:cellular defense response 0050435:amyloid-beta metabolic process 0019898:extrinsic component of membrane 0033197:response to vitamin E 0010613:positive regulation of cardiac muscle hypertrophy 0000407:phagophore assembly site 0071280:cellular response to copper ion 0016032:viral process 0043652:engulfment of apoptotic cell 0000045:autophagosome assembly 0051301:cell division 1905672:negative regulation of lysosome organization 0035032:phosphatidylinositol 3-kinase complex, class III 0034271:phosphatidylinositol 3-kinase complex, class III, type I 0016579:protein deubiquitination 0005802:trans-Golgi network 0005768:endosome 0000423:mitophagy 0010008:endosome membrane
PDB	5VAY ; 5VAX ; 6HOK ; 4MI8 ; 6DCN ; 6DCO ; 5VAU ; 6HOI ; 5HHE ; 2PON ; 5EFM ; 6HOJ ; 4DDP ; 2P1L ; 3DVU
Drugbank	DB13954 ; DB13952 ; DB00783 ; DB13955 ; DB13953 ; DB13956
KEGG	hsa:8678

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Name: Cis-Asarone

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Name: Berberine

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Name: Cytidine 5'-Phosphate

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0652	Xiang Yuan Pi	香橼皮	Wilson citron	Citrus medica
H0006	Bai Qu Cai	白屈菜	Greater celandine	Chelidonium majus
H0785	Ze Xi Huang Lian	择细黄连	Coptis deltoidea	Coptis chinensis
H1230	Huang Bai Fen	黄柏粉	Amur corktree	Phellodendron amurense
H0706	Yan Hu Suo	延胡索	Yanhusuo	Corydalis yanhusuo
H1165	He Shi	鹤虱	Common carpesium fruit	Fructus carpesii
H0029	Jiang Huang Lian	姜黄连	Coptis deltoidea	Coptis chinensis
H0651	Xiang Yuan	香橼	Wilson citron	Citrus medica
H1061	Bai He	百合	Lily	Lilium brownii
H0872	Chuan Huang Lian	川黄连	rhizome of chinese goldthread	Coptis chinensis
H0769	Yuan Zhi	远志	Thinleaf milkwort	Polygala tenuifolia
H0301	Ou	藕	Hindu lotus large rhizome	Nelumbo nucifera
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0082	Jiu Huang Lian	酒黄连	Coptis deltoidea	Coptis chinensis
H1188	Hong Hua	红花	Safflower	Carthamus tinctorius
H0682	Xiong Huang Lian	雄黄连	Coptis deltoidea	Coptis chinensis
H0304	Ou Pian	藕片	Hindu lotus large rhizome	Nelumbo nucifera
H0704	Yan Guan Huang Bai	盐关黄柏	Amur cork tree	Phellodendron amurense
H1243	Huang Lian Xu	黄连须	Coptis deltoidea	Coptis chinensis
H0699	Chang Pu	菖蒲	rhizome of grassleaf sweetflag.	Acorus calamus
H1164	He Geng	荷梗	Hindu lotus petiole	Nelumbo nucifera
H0302	Ou Fen	藕粉	Hindu lotus large rhizome	Nelumbo nucifera
H0452	Shi Chang Pu Qing Gao	石菖蒲清膏	Grassleaved sweetflag	Acorus tatarinowii
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1231	Huang Bai Tan	黄柏炭	Amur corktree	Phellodendron amurense
H0140	Lian Zi	莲子	Hindu lotus seed	Nelumbo nucifera
H1228	Huang Bai	黄柏	Amur corktree	Phellodendron amurense
H1068	Bai He Liu Jin Gao	百合流浸膏	Lily	Lilium brownii
H1090	Gao Ben	藁本	Chinese ligusticum	Ligusticum sinense
H0483	Shui Chang Pu	水菖蒲	Calamus	Acorus calamus var. angustatus
H1169	He Ye	荷叶	Hindu lotus leaf	Nelumbo nucifera
H0141	Lian Zi Xin	莲子心	Hindu lotus plumule	Nelumbo nucifera
H0450	Shi Chang Pu	石菖蒲	Grassleaved sweetflag	Acorus tatarinowii
H1115	Guan Huang Bai	关黄柏	Amur cork tree	Phellodendron amurense
H0164	Ban Zhi Lian	半枝莲	Barbed skullcap	Scutellaria barbata
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0827	Zhu Hong Jun	竹红菌	Bambusa hypocrella*	Hypocrella bambusae
H0633	Xia Tian Wu	夏天无	Decumbent corydalis	Corydalis decumbens
H0505	Cang Chang Pu	藏菖蒲	Sweet flag	Acorus calamus
H0771	Yuan Zhi Liu Jin Gao	远志流浸膏	Thinleaf milkwort	Polygala tenuifolia
H0770	Yuan Zhi Jin Gao	远志浸膏	Thinleaf milkwort	Polygala tenuifolia
H0451	Shi Chang Pu Jin Gao	石菖蒲浸膏	Grassleaved sweetflag	Acorus tatarinowii
H1242	Huang Lian Gan Jin Gao	黄连干浸膏	Coptis deltoidea	Coptis chinensis
H1241	Huang Lian	黄连	Coptis deltoidea	Coptis chinensis
H0760	Yu Huang Lian	萸黄连	Coptis deltoidea	Coptis chinensis

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 45)