Compound Description

ID:   C0041 Common name:   Emodin
IUPAC:  1,3,8-trihydroxy-6-methylanthracene-9,10-dione CAS:  CAS:518-82-1
Chembl ID:   CHEMBL289277 Pubchem ID:   CID:3220
Formula:  C15H10O5 TCM-ID:  TCMC1105
Smiles:  CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)O

Anthraquinone, 1,3,8-trihydroxy-6-methyl-;












Frangula emodin;

Frangulic acid;

NSC 408120;

NSC 622947;

Rheum emodin;


Related Targets  (Total: 57)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T76PKX Mast/stem cell growth factor receptor KitKIT P10721
A 1 Reference(s)
T40DIM Corticosteroid 11-beta-dehydrogenase isozyme 1HSD11B1 P28845
A 1 Reference(s)
T54VET Protein tyrosine phosphatase type IVA 3PTP4A3 O75365
A 1 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
A 1 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
A 2 Reference(s)
T37ADS Early growth response protein 1EGR1 P18146
A 1 Reference(s)
T96OOK Signal transducer and activator of transcription 3STAT3 P40763
A 2 Reference(s)
T20JZ2 Androgen receptorAR P10275
A 1 Reference(s)
T12RJE Casein kinase II subunit alpha'CSNK2A2 P19784
A 1 Reference(s)
T47C6A Phosphoglycerate mutase 1PGAM1 P18669
A 1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
A 1 Reference(s)
T58FWN Tyrosine-protein kinase BTKBTK Q06187
B 1 Reference(s)
T06Q1R Amine oxidase [flavin-containing] BMAOB P27338
B 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
B 1 Reference(s)
T01QLH Estrogen receptorESR1 P03372
B 1 Reference(s)
T80OJF Interstitial collagenaseMMP1 P03956
B 1 Reference(s)
T85U8U Caspase-3CASP3 P42574
B 1 Reference(s)
T27U96 Granulocyte-macrophage colony-stimulating factorCSF2 P04141
B 1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
B 1 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
B 1 Reference(s)
T84WE9 Vascular endothelial growth factor receptor 1FLT1 P17948
B 1 Reference(s)
T04MBA Vascular endothelial growth factor receptor 2KDR P35968
B 1 Reference(s)
T29JZ3 Vascular endothelial growth factor receptor 3FLT4 P35916
B 1 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
B 1 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
B 2 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
B 2 Reference(s)
T26EZU Myc proto-oncogene proteinMYC P01106
B 1 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
B 1 Reference(s)
T47H3O Heat shock protein HSP 90-alphaHSP90AA1 P07900
B 1 Reference(s)
T92BZ2 Catenin beta-1CTNNB1 P35222
B 1 Reference(s)
T52CKD Pro-epidermal growth factorEGF P01133
C 1 Reference(s)
T42PUG Solute carrier family 2, facilitated glucose transporter member 1SLC2A1 P11166
C 1 Reference(s)
T68SE0 Solute carrier family 2, facilitated glucose transporter member 4SLC2A4 P14672
C 1 Reference(s)
T63BQU Cytochrome P450 1A1CYP1A1 P04798
C 1 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
C 1 Reference(s)
T95K0K Interferon alpha-1/13IFNA1; IFNA13 P01562
C 1 Reference(s)
T64LKA Bile salt export pumpABCB11 O95342
C 2 Reference(s)
T93SFQ NAD-dependent protein deacetylase sirtuin-1SIRT1 Q96EB6
C 1 Reference(s)
T78O6C Mothers against decapentaplegic homolog 3SMAD3 P84022
C 1 Reference(s)
T84CEG Claudin-5CLDN5 O00501
C 1 Reference(s)
T30AEN Aquaporin-5AQP5 P55064
C 1 Reference(s)
T02GD4 Tumor necrosis factor ligand superfamily member 6FASLG P48023
C 1 Reference(s)
C 1 Reference(s)
T11BI7 Toll-like receptor 4TLR4 O00206
C 1 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
C 1 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
C 1 Reference(s)
T81I4T 5'-AMP-activated protein kinase catalytic subunit alpha-1PRKAA1 Q13131
C 1 Reference(s)
T75NEV Aquaporin-1AQP1 P29972
C 1 Reference(s)
T54SZZ Endoplasmic reticulum chaperone BiPHSPA5 P11021
C 1 Reference(s)
T37SV3 OccludinOCLN Q16625
C 1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
C 1 Reference(s)
T69F5W Forkhead box protein D3FOXD3 Q9UJU5
C 1 Reference(s)
T13I7C Transforming growth factor beta-2 proproteinTGFB2 P61812
C 1 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
C 1 Reference(s)
T44EUX Fragile X mental retardation syndrome-related protein 1FXR1 P51114
C 1 Reference(s)
T92LK2 Tumor necrosis factor ligand superfamily member 10TNFSF10 P50591
C 1 Reference(s)
T26CFB DNA damage-inducible transcript 3 proteinDDIT3 P35638;P0DPQ6
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 39)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1184 Bai Lian白蔹 Japanese ampelopsisAmpelopsis japonica
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0110 Ku Mu苦木 Indian quassiawoodPicrasma quassioides
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0853 Zi Wan紫菀 Tatarion asterAster tataricus
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H1011 Bai Chou白丑 Pharbitis seedSemen pharbitidis
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0102 Jue Ming Zi决明子 Sickle senna seedCassia tora
H0540 Tian Ji Huang田基黄 all - grass of japanese st. johnswortGrangea maderaspatana
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0452 Shi Chang Pu Qing Gao石菖蒲清膏 Grassleaved sweetflagAcorus tatarinowii
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H1223 Huai Hun Cao还魂草 NAAster tataricus
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0809 Zhi Mu知母 Common anemarrhenaAnemarrhena asphodeloides
H1173 Hei Chou黑丑 Pharbitis seedSemen pharbitidis
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0056 Jin Qiao Mai金荞麦 Wild buckwheat rhizomeRhizoma fagopyri cymosi
H1000 Dong Gua Zi冬瓜子 Chinese waxgourd seedBenincasa hispida
H0450 Shi Chang Pu石菖蒲 Grassleaved sweetflagAcorus tatarinowii
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0298 Niu Xi Xi牛西西 Patience dockRumex patientia
H0998 Dong Gua Pi冬瓜皮 Chinese waxgourd peelBenincasa hispida
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0250 Mi Zi Wan蜜紫菀 Tatarian asterAster tataricus
H1100 Gu Jing Cao谷精草 PipewartEriocaulon buergerianum
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0451 Shi Chang Pu Jin Gao石菖蒲浸膏 Grassleaved sweetflagAcorus tatarinowii
H0689 Xue Feng Teng血风藤 NAVentilago leiocarpa
H1235 Huang Hao黄蒿 Virg ate wormwoodArtemisia scoparia
H1026 Fan Hun Cao返魂草 Tatarian asterAster tataricus