Compound Description
| ID: C0041 | Common name: Emodin |
| IUPAC: 1,3,8-trihydroxy-6-methylanthracene-9,10-dione | CAS: CAS:518-82-1 |
| Chembl ID: CHEMBL289277 | Pubchem ID: CID:3220 |
| Formula: C15H10O5 | TCM-ID: TCMC1105 |
| Smiles: CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)O | |
| Alias:
Anthraquinone, 1,3,8-trihydroxy-6-methyl-;
1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione; 1,3,8-Trihydroxy-6-methyl-9,10-anthraquinone; 1,3,8-Trihydroxy-6-methyl-9,10-dihydroanthracene-9,10-dione; 1,3,8-Trihydroxy-6-methylanthraquinone; 1,6,8-Trihydroxy-3-methylanthraquinone; 3-Methyl-1,6,8-trihydroxyanthraquinone; 4,5,7-Trihydroxy-2-methylanthraquinone; Archin; Emodin; Emodine; Emodol; Frangula emodin; Frangulic acid; NSC 408120; NSC 622947; Rheum emodin; Schuttgelb |
Structure:
|
Related Targets (Total: 57)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T76PKX | Mast/stem cell growth factor receptor Kit | KIT |
P10721 |
A | 1 Reference(s) |
| T40DIM | Corticosteroid 11-beta-dehydrogenase isozyme 1 | HSD11B1 |
P28845 |
A | 1 Reference(s) |
| T54VET | Protein tyrosine phosphatase type IVA 3 | PTP4A3 |
O75365 |
A | 1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
A | 1 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
A | 2 Reference(s) |
| T37ADS | Early growth response protein 1 | EGR1 |
P18146 |
A | 1 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
A | 2 Reference(s) |
| T20JZ2 | Androgen receptor | AR |
P10275 |
A | 1 Reference(s) |
| T12RJE | Casein kinase II subunit alpha' | CSNK2A2 |
P19784 |
A | 1 Reference(s) |
| T47C6A | Phosphoglycerate mutase 1 | PGAM1 |
P18669 |
A | 1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
A | 1 Reference(s) |
| T58FWN | Tyrosine-protein kinase BTK | BTK |
Q06187 |
B | 1 Reference(s) |
| T06Q1R | Amine oxidase [flavin-containing] B | MAOB |
P27338 |
B | 1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
B | 1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
B | 1 Reference(s) |
| T80OJF | Interstitial collagenase | MMP1 |
P03956 |
B | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
B | 1 Reference(s) |
| T27U96 | Granulocyte-macrophage colony-stimulating factor | CSF2 |
P04141 |
B | 1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
B | 1 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
B | 1 Reference(s) |
| T84WE9 | Vascular endothelial growth factor receptor 1 | FLT1 |
P17948 |
B | 1 Reference(s) |
| T04MBA | Vascular endothelial growth factor receptor 2 | KDR |
P35968 |
B | 1 Reference(s) |
| T29JZ3 | Vascular endothelial growth factor receptor 3 | FLT4 |
P35916 |
B | 1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
B | 1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
B | 2 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
B | 2 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
B | 1 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
B | 1 Reference(s) |
| T47H3O | Heat shock protein HSP 90-alpha | HSP90AA1 |
P07900 |
B | 1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
B | 1 Reference(s) |
| T52CKD | Pro-epidermal growth factor | EGF |
P01133 |
C | 1 Reference(s) |
| T42PUG | Solute carrier family 2, facilitated glucose transporter member 1 | SLC2A1 |
P11166 |
C | 1 Reference(s) |
| T68SE0 | Solute carrier family 2, facilitated glucose transporter member 4 | SLC2A4 |
P14672 |
C | 1 Reference(s) |
| T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
C | 1 Reference(s) |
| T53AOE | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide | TGFB1 |
P01137 |
C | 1 Reference(s) |
| T95K0K | Interferon alpha-1/13 | IFNA1; IFNA13 |
P01562 |
C | 1 Reference(s) |
| T64LKA | Bile salt export pump | ABCB11 |
O95342 |
C | 2 Reference(s) |
| T93SFQ | NAD-dependent protein deacetylase sirtuin-1 | SIRT1 |
Q96EB6 |
C | 1 Reference(s) |
| T78O6C | Mothers against decapentaplegic homolog 3 | SMAD3 |
P84022 |
C | 1 Reference(s) |
| T84CEG | Claudin-5 | CLDN5 |
O00501 |
C | 1 Reference(s) |
| T30AEN | Aquaporin-5 | AQP5 |
P55064 |
C | 1 Reference(s) |
| T02GD4 | Tumor necrosis factor ligand superfamily member 6 | FASLG |
P48023 |
C | 1 Reference(s) |
| T47RAK | NA | MIR145 |
NA |
C | 1 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
C | 1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
C | 1 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
C | 1 Reference(s) |
| T81I4T | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | PRKAA1 |
Q13131 |
C | 1 Reference(s) |
| T75NEV | Aquaporin-1 | AQP1 |
P29972 |
C | 1 Reference(s) |
| T54SZZ | Endoplasmic reticulum chaperone BiP | HSPA5 |
P11021 |
C | 1 Reference(s) |
| T37SV3 | Occludin | OCLN |
Q16625 |
C | 1 Reference(s) |
| T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
C | 1 Reference(s) |
| T69F5W | Forkhead box protein D3 | FOXD3 |
Q9UJU5 |
C | 1 Reference(s) |
| T13I7C | Transforming growth factor beta-2 proprotein | TGFB2 |
P61812 |
C | 1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
C | 1 Reference(s) |
| T44EUX | Fragile X mental retardation syndrome-related protein 1 | FXR1 |
P51114 |
C | 1 Reference(s) |
| T92LK2 | Tumor necrosis factor ligand superfamily member 10 | TNFSF10 |
P50591 |
C | 1 Reference(s) |
| T26CFB | DNA damage-inducible transcript 3 protein | DDIT3 |
P35638;P0DPQ6 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 39)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0540 | Tian Ji Huang | 田基黄 | all - grass of japanese st. johnswort | Grangea maderaspatana |
| H0809 | Zhi Mu | 知母 | Common anemarrhena | Anemarrhena asphodeloides |
| H1026 | Fan Hun Cao | 返魂草 | Tatarian aster | Aster tataricus |
| H1066 | Gan Cao | 甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0853 | Zi Wan | 紫菀 | Tatarion aster | Aster tataricus |
| H1070 | Gan Cao Gan Gao Fen | 甘草干膏粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1223 | Huai Hun Cao | 还魂草 | NA | Aster tataricus |
| H1072 | Gan Cao Gao | 甘草膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1074 | Gan Cao Jin Gao | 甘草浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0926 | Da Huang | 大黄 | Medicinal rhubarb | Rheum officinale |
| H1184 | Bai Lian | 白蔹 | Japanese ampelopsis | Ampelopsis japonica |
| H0472 | Shu Da Huang | 熟大黄 | NA | Rheum palmatum |
| H0110 | Ku Mu | 苦木 | Indian quassiawood | Picrasma quassioides |
| H1069 | Gan Cao Gan Gao | 甘草干膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0444 | Sheng Gan Cao | 生甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1075 | Gan Cao Liu Jin Gao | 甘草流浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0450 | Shi Chang Pu | 石菖蒲 | Grassleaved sweetflag | Acorus tatarinowii |
| H1166 | He Shou Wu | 何首乌 | Tuber fleeceflower | Polygonum multiflorum |
| H0102 | Jue Ming Zi | 决明子 | Sickle senna seed | Cassia tora |
| H1100 | Gu Jing Cao | 谷精草 | Pipewart | Eriocaulon buergerianum |
| H1235 | Huang Hao | 黄蒿 | Virg ate wormwood | Artemisia scoparia |
| H0928 | Da Huang Liu Jin Gao | 大黄流浸膏 | Medicinal rhubarb | Rheum officinale |
| H1073 | Gan Cao Jie | 甘草节 | Glycyrrhiza uralensis fisch | Glycyrrhiza uralensis |
| H0250 | Mi Zi Wan | 蜜紫菀 | Tatarian aster | Aster tataricus |
| H0451 | Shi Chang Pu Jin Gao | 石菖蒲浸膏 | Grassleaved sweetflag | Acorus tatarinowii |
| H1067 | Gan Cao Fen | 甘草粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0689 | Xue Feng Teng | 血风藤 | NA | Ventilago leiocarpa |
| H0298 | Niu Xi Xi | 牛西西 | Patience dock | Rumex patientia |
| H0452 | Shi Chang Pu Qing Gao | 石菖蒲清膏 | Grassleaved sweetflag | Acorus tatarinowii |
| H1000 | Dong Gua Zi | 冬瓜子 | Chinese waxgourd seed | Benincasa hispida |
| H1213 | Hu Zhang | 虎杖 | Japanese fleeceflower | Polygonum cuspidatum |
| H0927 | Da Huang Jin Gao | 大黄浸膏 | Medicinal rhubarb | Rheum officinale |
| H1011 | Bai Chou | 白丑 | Pharbitis seed | Semen pharbitidis |
| H0056 | Jin Qiao Mai | 金荞麦 | Wild buckwheat rhizome | Rhizoma fagopyri cymosi |
| H0571 | Tu Gan Cao | 土甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1071 | Gan Cao Gan Jin Gao | 甘草干浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1173 | Hei Chou | 黑丑 | Pharbitis seed | Semen pharbitidis |
| H0998 | Dong Gua Pi | 冬瓜皮 | Chinese waxgourd peel | Benincasa hispida |
| H0240 | Mi Gan Cao | 蜜甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
Ckey description of the interaction between compound and target