Target Description

Type Detail
Target ID T76PKX
Protein Name Mast/stem cell growth factor receptor Kit
Uniprot ID P10721
Protein Name Alias SCFR;  EC 2.7.10.1;  Piebald trait protein;  PBT;  Proto-oncogene c-Kit;  Tyrosine-protein kinase Kit;  p145 c-kit;  v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog;  CD antigen CD117
Gene ID 3815
Gene Symbol KIT
Gene Alias SCFR
TTD T57700: Successful target
Pfam PF07714 ; PF00047
GO
0046872:metal ion binding

0007275:multicellular organism development

0008360:regulation of cell shape

0000187:activation of MAPK activity

0043552:positive regulation of phosphatidylinositol 3-kinase activity

0097324:melanocyte migration

1904349:positive regulation of small intestine smooth muscle contraction

0042803:protein homodimerization activity

0002327:immature B cell differentiation

0043410:positive regulation of MAPK cascade

0005524:ATP binding

0008354:germ cell migration

0048863:stem cell differentiation

0019827:stem cell population maintenance

0002551:mast cell chemotaxis

0043586:tongue development

0006357:regulation of transcription by RNA polymerase II

0001541:ovarian follicle development

0030318:melanocyte differentiation

0001650:fibrillar center

0043235:receptor complex

0120072:positive regulation of pyloric antrum smooth muscle contraction

0001669:acrosomal vesicle

0051897:positive regulation of protein kinase B signaling

0048565:digestive tract development

0002020:protease binding

0005887:integral component of plasma membrane

0008284:positive regulation of cell population proliferation

0042531:positive regulation of tyrosine phosphorylation of STAT protein

0030218:erythrocyte differentiation

0042127:regulation of cell population proliferation

0043473:pigmentation

0009898:cytoplasmic side of plasma membrane

0035019:somatic stem cell population maintenance

0005020:stem cell factor receptor activity

0002732:positive regulation of dendritic cell cytokine production

0038109:Kit signaling pathway

0007169:transmembrane receptor protein tyrosine kinase signaling pathway

0004713:protein tyrosine kinase activity

0043069:negative regulation of programmed cell death

0035234:ectopic germ cell programmed cell death

0060326:cell chemotaxis

0030217:T cell differentiation

0031532:actin cytoskeleton reorganization

0060374:mast cell differentiation

0032765:positive regulation of mast cell cytokine production

0035855:megakaryocyte development

0042169:SH2 domain binding

0005886:plasma membrane

0046777:protein autophosphorylation

0046686:response to cadmium ion

0045747:positive regulation of Notch signaling pathway

0005911:cell-cell junction

0019955:cytokine binding

0097067:cellular response to thyroid hormone stimulus

0051091:positive regulation of DNA-binding transcription factor activity

0043406:positive regulation of MAP kinase activity

0008542:visual learning

0046427:positive regulation of receptor signaling pathway via JAK-STAT

0006954:inflammatory response

0002244:hematopoietic progenitor cell differentiation

0007283:spermatogenesis

0007165:signal transduction

0031274:positive regulation of pseudopodium assembly

0004714:transmembrane receptor protein tyrosine kinase activity

0035701:hematopoietic stem cell migration

0008584:male gonad development

0038093:Fc receptor signaling pathway

0050673:epithelial cell proliferation

1904343:positive regulation of colon smooth muscle contraction

0030183:B cell differentiation

0002318:myeloid progenitor cell differentiation

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0030032:lamellipodium assembly

0019221:cytokine-mediated signaling pathway

0070662:mast cell proliferation

0018108:peptidyl-tyrosine phosphorylation

0009897:external side of plasma membrane

0035162:embryonic hemopoiesis

0048103:somatic stem cell division

0005615:extracellular space

0002320:lymphoid progenitor cell differentiation

0048170:positive regulation of long-term neuronal synaptic plasticity

0033674:positive regulation of kinase activity

0000165:MAPK cascade

0050910:detection of mechanical stimulus involved in sensory perception of sound

0030335:positive regulation of cell migration

0010863:positive regulation of phospholipase C activity

0097326:melanocyte adhesion

1904251:regulation of bile acid metabolic process

1905065:positive regulation of vascular associated smooth muscle cell differentiation

0038162:erythropoietin-mediated signaling pathway

0007286:spermatid development

0030097:hemopoiesis

0006687:glycosphingolipid metabolic process

0043303:mast cell degranulation

PDB 1QZK ; 6GQJ ; 2E9W ; 4K94 ; 4K9E ; 1PKG ; 2IUH ; 6XVB ; 2VIF ; 1R01 ; 1T46 ; 3G0E ; 6KLA ; 6XV9 ; 6GQM ; 3G0F ; 4U0I ; 6MOB ; 6HH1 ; 1T45 ; 6XVA ; 4HVS ; 6GQK ; 6ITV ; 6ITT ; 1QZJ ; 6GQL ; 2EC8 ; 4PGZ
Drugbank DB08896 ; DB12147 ; DB15233 ; DB09103 ; DB12010 ; DB09078 ; DB12978 ; DB05146 ; DB08901 ; DB04868 ; DB01254 ; DB06080 ; DB01268 ; DB05913 ; DB00398 ; DB01962 ; DB12742 ; DB06595 ; DB14840 ; DB00619 ; DB06589
KEGG hsa:3815

Related Compounds  (Total: 4)

Go to browser
C0041
Name: Emodin
Go to browser
C0249
Name: Nobiletin
Go to browser
C0575
Name: Ppi
Go to browser
C1223
Name: Celecoxib


Related Herbs  (Total: 53)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1173 Hei Chou黑丑 Pharbitis seedSemen pharbitidis
H0540 Tian Ji Huang田基黄 all - grass of japanese st. johnswortGrangea maderaspatana
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H1100 Gu Jing Cao谷精草 PipewartEriocaulon buergerianum
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0651 Xiang Yuan香橼 Wilson citronCitrus medica
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0813 Zhi Shi枳实 Seville orange young fruitCitrus aurantium
H0451 Shi Chang Pu Jin Gao石菖蒲浸膏 Grassleaved sweetflagAcorus tatarinowii
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0758 Cheng Pi橙皮 Bitter orangeCitrus aurantium
H0182 Luo Bu Ma Ye罗布麻叶 NAApocyni veneti folium
H0093 Ju Pi橘皮 Tangerine pericarpCitrus reticulata
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1184 Bai Lian白蔹 Japanese ampelopsisAmpelopsis japonica
H0250 Mi Zi Wan蜜紫菀 Tatarian asterAster tataricus
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1000 Dong Gua Zi冬瓜子 Chinese waxgourd seedBenincasa hispida
H0853 Zi Wan紫菀 Tatarion asterAster tataricus
H0998 Dong Gua Pi冬瓜皮 Chinese waxgourd peelBenincasa hispida
H0652 Xiang Yuan Pi香橼皮 Wilson citronCitrus medica
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H1026 Fan Hun Cao返魂草 Tatarian asterAster tataricus
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H1223 Huai Hun Cao还魂草 NAAster tataricus
H0298 Niu Xi Xi牛西西 Patience dockRumex patientia
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0604 Wu Wei Teng五味藤 NASecuridaca inappendiculata
H0450 Shi Chang Pu石菖蒲 Grassleaved sweetflagAcorus tatarinowii
H0802 Zhi Geng枳梗 NACitrus aurantium
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0689 Xue Feng Teng血风藤 NAVentilago leiocarpa
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0809 Zhi Mu知母 Common anemarrhenaAnemarrhena asphodeloides
H0110 Ku Mu苦木 Indian quassiawoodPicrasma quassioides
H0102 Jue Ming Zi决明子 Sickle senna seedCassia tora
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H1011 Bai Chou白丑 Pharbitis seedSemen pharbitidis
H0056 Jin Qiao Mai金荞麦 Wild buckwheat rhizomeRhizoma fagopyri cymosi
H1235 Huang Hao黄蒿 Virg ate wormwoodArtemisia scoparia
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0088 Ju He橘核 Tangerine seedCitrus reticulata
H0805 Zhi Ke Gan Jin Gao枳壳干浸膏 Seville ora nge unripe fruitCitrus aurantium
H0452 Shi Chang Pu Qing Gao石菖蒲清膏 Grassleaved sweetflagAcorus tatarinowii