HIT-result

Type	Detail
Target ID	T58FWN
Protein Name	Tyrosine-protein kinase BTK
Uniprot ID	Q06187
Protein Name Alias	EC 2.7.10.2; Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinase
Gene ID	695
Gene Symbol	BTK
Gene Alias	AGMX1; ATK; BPK
TTD	T25005: Successful target
Pfam	PF00779 ; PF00169 ; PF07714 ; PF00017 ; PF00018
GO	0002553:histamine secretion by mast cell 0002755:MyD88-dependent toll-like receptor signaling pathway 0004713:protein tyrosine kinase activity 0035556:intracellular signal transduction 0004715:non-membrane spanning protein tyrosine kinase activity 0005524:ATP binding 0097190:apoptotic signaling pathway 0050853:B cell receptor signaling pathway 0018108:peptidyl-tyrosine phosphorylation 0006468:protein phosphorylation 0007186:G protein-coupled receptor signaling pathway 0030889:negative regulation of B cell proliferation 0046872:metal ion binding 0038095:Fc-epsilon receptor signaling pathway 0005829:cytosol 0002721:regulation of B cell cytokine production 0042802:identical protein binding 0046777:protein autophosphorylation 0002902:regulation of B cell apoptotic process 0007498:mesoderm development 0002250:adaptive immune response 0005547:phosphatidylinositol-3,4,5-trisphosphate binding 0005886:plasma membrane 0005737:cytoplasm 0098761:cellular response to interleukin-7 0045087:innate immune response 0045579:positive regulation of B cell differentiation 0071226:cellular response to molecule of fungal origin 0001812:positive regulation of type I hypersensitivity 0002344:B cell affinity maturation 0048471:perinuclear region of cytoplasm 0007249:I-kappaB kinase/NF-kappaB signaling 0001818:negative regulation of cytokine production 0048469:cell maturation 0005634:nucleus 0045121:membrane raft 0051092:positive regulation of NF-kappaB transcription factor activity 0042113:B cell activation 0034614:cellular response to reactive oxygen species 0019722:calcium-mediated signaling 0004714:transmembrane receptor protein tyrosine kinase activity 0031410:cytoplasmic vesicle 0001805:positive regulation of type III hypersensitivity
PDB	6TT2 ; 5JRS ; 6N9P ; 4Z3V ; 3PJ3 ; 1BWN ; 3PJ2 ; 5P9I ; 4OTQ ; 3OCT ; 6W07 ; 2GE9 ; 5P9M ; 5VFI ; 5FBN ; 6NFH ; 5P9L ; 5KUP ; 5J87 ; 5VGO ; 6BKH ; 5P9G ; 5P9K ; 6W8I ; 6X3O ; 6E4F ; 5ZZ4 ; 6TFP ; 6S90 ; 4YHF ; 6DI9 ; 1K2P ; 6NZM ; 6NFI ; 4ZLZ ; 6DI5 ; 3P08 ; 5XYZ ; 3PIX ; 4ZLY ; 6DI0 ; 6XE4 ; 4RFY ; 5P9J ; 4OT6 ; 4RG0 ; 6OMU ; 6W06 ; 1BTK ; 6J6M ; 6W7O ; 5BQ0 ; 6AUB ; 6X3P ; 4NWM ; 6O8I ; 6HRT ; 6BKE ; 4OTR ; 5BPY ; 5FBO ; 6TSE ; 6TVN ; 3OCS ; 6X3N ; 3PIZ ; 6VXQ ; 1QLY ; 5U9D ; 6BKW ; 3PJ1 ; 3GEN ; 4OT5 ; 4RFZ ; 1B55 ; 6HRP ; 4OTF ; 5T18 ; 6BIK ; 6AUA ; 6EP9 ; 6TUH ; 1AWX ; 6BLN ; 3PIY ; 6HTF ; 4RX5 ; 5P9F ; 1AWW ; 2Z0P ; 3K54 ; 6DI1 ; 5P9H ; 6DI3
Drugbank	DB15327 ; DB05204 ; DB01863 ; DB15035 ; DB09053 ; DB11703 ; DB01254 ; DB12010
KEGG	hsa:695

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Name: Emodin

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Name: Pyridine

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0102	Jue Ming Zi	决明子	Sickle senna seed	Cassia tora
H1055	Bai Guo Ren	白果仁	ginkgo	Ginkgo biloba
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0250	Mi Zi Wan	蜜紫菀	Tatarian aster	Aster tataricus
H0110	Ku Mu	苦木	Indian quassiawood	Picrasma quassioides
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H0452	Shi Chang Pu Qing Gao	石菖蒲清膏	Grassleaved sweetflag	Acorus tatarinowii
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0340	Bi Ma Zi	蓖麻子	Castorbean seed	Ricinus communis
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H0451	Shi Chang Pu Jin Gao	石菖蒲浸膏	Grassleaved sweetflag	Acorus tatarinowii
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0326	Bi Ma Gen	蓖麻根	Castorbean root	Ricinus communis
H1051	Bai Guo	白果	Ginkgo nut	Ginkgo biloba
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0334	Bi Ma Ren	蓖麻仁	Ricinus	Ricinus communis
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H1026	Fan Hun Cao	返魂草	Tatarian aster	Aster tataricus
H1173	Hei Chou	黑丑	Pharbitis seed	Semen pharbitidis
H0298	Niu Xi Xi	牛西西	Patience dock	Rumex patientia
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0321	Bi Ma	蓖麻	castor oil plant	Ricinus communis
H0056	Jin Qiao Mai	金荞麦	Wild buckwheat rhizome	Rhizoma fagopyri cymosi
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1235	Huang Hao	黄蒿	Virg ate wormwood	Artemisia scoparia
H0689	Xue Feng Teng	血风藤	NA	Ventilago leiocarpa
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0450	Shi Chang Pu	石菖蒲	Grassleaved sweetflag	Acorus tatarinowii
H0750	Yin Xing Ye	银杏叶	Folium ginkgo	Ginkgo biloba
H1100	Gu Jing Cao	谷精草	Pipewart	Eriocaulon buergerianum
H0853	Zi Wan	紫菀	Tatarion aster	Aster tataricus
H0540	Tian Ji Huang	田基黄	all - grass of japanese st. johnswort	Grangea maderaspatana
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1000	Dong Gua Zi	冬瓜子	Chinese waxgourd seed	Benincasa hispida
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1184	Bai Lian	白蔹	Japanese ampelopsis	Ampelopsis japonica
H1011	Bai Chou	白丑	Pharbitis seed	Semen pharbitidis
H0416	Shan Shen	山参	NA	Panax ginseng
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0998	Dong Gua Pi	冬瓜皮	Chinese waxgourd peel	Benincasa hispida
H1223	Huai Hun Cao	还魂草	NA	Aster tataricus

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 54)