Target Description

Type Detail
Target ID T58FWN
Protein Name Tyrosine-protein kinase BTK
Uniprot ID Q06187
Protein Name Alias EC 2.7.10.2;  Agammaglobulinemia tyrosine kinase;  ATK;  B-cell progenitor kinase;  BPK;  Bruton tyrosine kinase
Gene ID 695
Gene Symbol BTK
Gene Alias AGMX1;  ATK;  BPK
TTD T25005: Successful target
Pfam PF00779 ; PF00169 ; PF07714 ; PF00017 ; PF00018
GO
0002553:histamine secretion by mast cell

0002755:MyD88-dependent toll-like receptor signaling pathway

0004713:protein tyrosine kinase activity

0035556:intracellular signal transduction

0004715:non-membrane spanning protein tyrosine kinase activity

0005524:ATP binding

0097190:apoptotic signaling pathway

0050853:B cell receptor signaling pathway

0018108:peptidyl-tyrosine phosphorylation

0006468:protein phosphorylation

0007186:G protein-coupled receptor signaling pathway

0030889:negative regulation of B cell proliferation

0046872:metal ion binding

0038095:Fc-epsilon receptor signaling pathway

0005829:cytosol

0002721:regulation of B cell cytokine production

0042802:identical protein binding

0046777:protein autophosphorylation

0002902:regulation of B cell apoptotic process

0007498:mesoderm development

0002250:adaptive immune response

0005547:phosphatidylinositol-3,4,5-trisphosphate binding

0005886:plasma membrane

0005737:cytoplasm

0098761:cellular response to interleukin-7

0045087:innate immune response

0045579:positive regulation of B cell differentiation

0071226:cellular response to molecule of fungal origin

0001812:positive regulation of type I hypersensitivity

0002344:B cell affinity maturation

0048471:perinuclear region of cytoplasm

0007249:I-kappaB kinase/NF-kappaB signaling

0001818:negative regulation of cytokine production

0048469:cell maturation

0005634:nucleus

0045121:membrane raft

0051092:positive regulation of NF-kappaB transcription factor activity

0042113:B cell activation

0034614:cellular response to reactive oxygen species

0019722:calcium-mediated signaling

0004714:transmembrane receptor protein tyrosine kinase activity

0031410:cytoplasmic vesicle

0001805:positive regulation of type III hypersensitivity

PDB 6TT2 ; 5JRS ; 6N9P ; 4Z3V ; 3PJ3 ; 1BWN ; 3PJ2 ; 5P9I ; 4OTQ ; 3OCT ; 6W07 ; 2GE9 ; 5P9M ; 5VFI ; 5FBN ; 6NFH ; 5P9L ; 5KUP ; 5J87 ; 5VGO ; 6BKH ; 5P9G ; 5P9K ; 6W8I ; 6X3O ; 6E4F ; 5ZZ4 ; 6TFP ; 6S90 ; 4YHF ; 6DI9 ; 1K2P ; 6NZM ; 6NFI ; 4ZLZ ; 6DI5 ; 3P08 ; 5XYZ ; 3PIX ; 4ZLY ; 6DI0 ; 6XE4 ; 4RFY ; 5P9J ; 4OT6 ; 4RG0 ; 6OMU ; 6W06 ; 1BTK ; 6J6M ; 6W7O ; 5BQ0 ; 6AUB ; 6X3P ; 4NWM ; 6O8I ; 6HRT ; 6BKE ; 4OTR ; 5BPY ; 5FBO ; 6TSE ; 6TVN ; 3OCS ; 6X3N ; 3PIZ ; 6VXQ ; 1QLY ; 5U9D ; 6BKW ; 3PJ1 ; 3GEN ; 4OT5 ; 4RFZ ; 1B55 ; 6HRP ; 4OTF ; 5T18 ; 6BIK ; 6AUA ; 6EP9 ; 6TUH ; 1AWX ; 6BLN ; 3PIY ; 6HTF ; 4RX5 ; 5P9F ; 1AWW ; 2Z0P ; 3K54 ; 6DI1 ; 5P9H ; 6DI3
Drugbank DB15327 ; DB05204 ; DB01863 ; DB15035 ; DB09053 ; DB11703 ; DB01254 ; DB12010
KEGG hsa:695

Related Compounds  (Total: 2)

Go to browser
C0041
Name: Emodin
Go to browser
C0344
Name: Pyridine


Related Herbs  (Total: 54)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0056 Jin Qiao Mai金荞麦 Wild buckwheat rhizomeRhizoma fagopyri cymosi
H0472 Shu Da Huang熟大黄 NARheum palmatum
H1235 Huang Hao黄蒿 Virg ate wormwoodArtemisia scoparia
H1011 Bai Chou白丑 Pharbitis seedSemen pharbitidis
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H0452 Shi Chang Pu Qing Gao石菖蒲清膏 Grassleaved sweetflagAcorus tatarinowii
H0689 Xue Feng Teng血风藤 NAVentilago leiocarpa
H0298 Niu Xi Xi牛西西 Patience dockRumex patientia
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1184 Bai Lian白蔹 Japanese ampelopsisAmpelopsis japonica
H0110 Ku Mu苦木 Indian quassiawoodPicrasma quassioides
H0357 Ren Shen人参 GinsengPanax ginseng
H0853 Zi Wan紫菀 Tatarion asterAster tataricus
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0451 Shi Chang Pu Jin Gao石菖蒲浸膏 Grassleaved sweetflagAcorus tatarinowii
H0102 Jue Ming Zi决明子 Sickle senna seedCassia tora
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0450 Shi Chang Pu石菖蒲 Grassleaved sweetflagAcorus tatarinowii
H0340 Bi Ma Zi蓖麻子 Castorbean seedRicinus communis
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0334 Bi Ma Ren蓖麻仁 RicinusRicinus communis
H0998 Dong Gua Pi冬瓜皮 Chinese waxgourd peelBenincasa hispida
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0540 Tian Ji Huang田基黄 all - grass of japanese st. johnswortGrangea maderaspatana
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0416 Shan Shen山参 NAPanax ginseng
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0250 Mi Zi Wan蜜紫菀 Tatarian asterAster tataricus
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0809 Zhi Mu知母 Common anemarrhenaAnemarrhena asphodeloides
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H1000 Dong Gua Zi冬瓜子 Chinese waxgourd seedBenincasa hispida
H1026 Fan Hun Cao返魂草 Tatarian asterAster tataricus
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1223 Huai Hun Cao还魂草 NAAster tataricus
H1100 Gu Jing Cao谷精草 PipewartEriocaulon buergerianum
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0321 Bi Ma蓖麻 castor oil plantRicinus communis
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H1173 Hei Chou黑丑 Pharbitis seedSemen pharbitidis
H0326 Bi Ma Gen蓖麻根 Castorbean rootRicinus communis
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis