Target Description

Type Detail
Target ID T84WE9
Protein Name Vascular endothelial growth factor receptor 1
Uniprot ID P17948
Protein Name Alias VEGFR-1;  EC 2.7.10.1;  Fms-like tyrosine kinase 1;  FLT-1;  Tyrosine-protein kinase FRT;  Tyrosine-protein kinase receptor FLT;  FLT;  Vascular permeability factor receptor
Gene ID 2321
Gene Symbol FLT1
Gene Alias FLT;  FRT;  VEGFR1
TTD T63966: Successful target
Pfam PF17988 ; PF00047 ; PF07679 ; PF07714
GO
0048598:embryonic morphogenesis

0002548:monocyte chemotaxis

0043410:positive regulation of MAPK cascade

0005615:extracellular space

0005524:ATP binding

0035924:cellular response to vascular endothelial growth factor stimulus

0018108:peptidyl-tyrosine phosphorylation

0007169:transmembrane receptor protein tyrosine kinase signaling pathway

0016477:cell migration

0002244:hematopoietic progenitor cell differentiation

0036332:placental growth factor-activated receptor activity

0005925:focal adhesion

0019838:growth factor binding

0001525:angiogenesis

0007275:multicellular organism development

0046777:protein autophosphorylation

0010863:positive regulation of phospholipase C activity

0043552:positive regulation of phosphatidylinositol 3-kinase activity

0048010:vascular endothelial growth factor receptor signaling pathway

0005886:plasma membrane

0033674:positive regulation of kinase activity

0005768:endosome

0015629:actin cytoskeleton

0005887:integral component of plasma membrane

0005021:vascular endothelial growth factor-activated receptor activity

0030335:positive regulation of cell migration

0036323:vascular endothelial growth factor receptor-1 signaling pathway

0043235:receptor complex

0045766:positive regulation of angiogenesis

0048514:blood vessel morphogenesis

0008284:positive regulation of cell population proliferation

1905563:negative regulation of vascular endothelial cell proliferation

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0043406:positive regulation of MAP kinase activity

0004714:transmembrane receptor protein tyrosine kinase activity

1990384:hyaloid vascular plexus regression

PDB 1QTY ; 1RV6 ; 4CL7 ; 2XAC ; 1FLT ; 1QSV ; 5ABD ; 5EX3 ; 4CKV ; 3HNG ; 5T89 ; 1QSZ
Drugbank DB01268 ; DB06589 ; DB07288 ; DB06101 ; DB05913 ; DB06626 ; DB12010 ; DB09079 ; DB06080 ; DB05075 ; DB00398 ; DB08896 ; DB09078 ; DB09221 ; DB05932 ; DB15685 ; DB10770 ; DB04879
KEGG hsa:2321

Related Compounds  (Total: 6)

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C0041
Name: Emodin
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C0047
Name: Epigalocatechin Gallate
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C0210
Name: Melatonin
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C0974
Name: dihydroartemisinin
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C1113
Name: heparin


Related Herbs  (Total: 63)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0056 Jin Qiao Mai金荞麦 Wild buckwheat rhizomeRhizoma fagopyri cymosi
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0818 Zhi Zi栀子 Cape jasmine fruitGardenia jasminoides
H1235 Huang Hao黄蒿 Virg ate wormwoodArtemisia scoparia
H1011 Bai Chou白丑 Pharbitis seedSemen pharbitidis
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0189 Lv Cha绿茶 Green teaFolium camelliae sinensis
H0353 Que Mei Teng Gen雀梅藤根 Hedge sageretiaSageretia thea
H0452 Shi Chang Pu Qing Gao石菖蒲清膏 Grassleaved sweetflagAcorus tatarinowii
H0689 Xue Feng Teng血风藤 NAVentilago leiocarpa
H0130 Lei Gong Teng雷公藤 Common threewingnutTripterygium wilfordii
H0298 Niu Xi Xi牛西西 Patience dockRumex patientia
H0721 Yang Mei Gen杨梅根 Myrica rubra sieb. et zuccMyrica rubra
H1029 Fang Er Cha方儿茶 khair in hindiSenegalia catechu
H0819 Zhi Zi Jin Gao栀子浸膏 Cape jasmine fruitGardenia jasminoides
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1184 Bai Lian白蔹 Japanese ampelopsisAmpelopsis japonica
H0110 Ku Mu苦木 Indian quassiawoodPicrasma quassioides
H0853 Zi Wan紫菀 Tatarion asterAster tataricus
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0451 Shi Chang Pu Jin Gao石菖蒲浸膏 Grassleaved sweetflagAcorus tatarinowii
H0102 Jue Ming Zi决明子 Sickle senna seedCassia tora
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0284 Nan She Teng南蛇藤 Oriental bittersweetCelastrus orbiculatus
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0450 Shi Chang Pu石菖蒲 Grassleaved sweetflagAcorus tatarinowii
H0692 Xue Ren Shen血人参 NALespedeza bicolor
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0998 Dong Gua Pi冬瓜皮 Chinese waxgourd peelBenincasa hispida
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0540 Tian Ji Huang田基黄 all - grass of japanese st. johnswortGrangea maderaspatana
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0250 Mi Zi Wan蜜紫菀 Tatarian asterAster tataricus
H0809 Zhi Mu知母 Common anemarrhenaAnemarrhena asphodeloides
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H1000 Dong Gua Zi冬瓜子 Chinese waxgourd seedBenincasa hispida
H1026 Fan Hun Cao返魂草 Tatarian asterAster tataricus
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1223 Huai Hun Cao还魂草 NAAster tataricus
H1100 Gu Jing Cao谷精草 PipewartEriocaulon buergerianum
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0424 Shan Zhi山栀 Cape jasmineGardenia jasminoides
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1004 Bai Cha白茶 White teaCamellia sinensis
H1173 Hei Chou黑丑 Pharbitis seedSemen pharbitidis
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis