HIT-result

Type	Detail
Target ID	T29JZ3
Protein Name	Vascular endothelial growth factor receptor 3
Uniprot ID	P35916
Protein Name Alias	VEGFR-3; EC 2.7.10.1; Fms-like tyrosine kinase 4; FLT-4; Tyrosine-protein kinase receptor FLT4
Gene ID	2324
Gene Symbol	FLT4
Gene Alias	VEGFR3
TTD	T07303: Successful target
Pfam	PF07714 ; PF17988 ; PF07679
GO	0019838:growth factor binding 0005829:cytosol 0001946:lymphangiogenesis 0007275:multicellular organism development 0003016:respiratory system process 0001934:positive regulation of protein phosphorylation 0038084:vascular endothelial growth factor signaling pathway 0018108:peptidyl-tyrosine phosphorylation 0002244:hematopoietic progenitor cell differentiation 0042803:protein homodimerization activity 0043066:negative regulation of apoptotic process 0007169:transmembrane receptor protein tyrosine kinase signaling pathway 0005654:nucleoplasm 0002040:sprouting angiogenesis 0046330:positive regulation of JNK cascade 0043410:positive regulation of MAPK cascade 0001938:positive regulation of endothelial cell proliferation 0004714:transmembrane receptor protein tyrosine kinase activity 0005524:ATP binding 0033674:positive regulation of kinase activity 0090037:positive regulation of protein kinase C signaling 0019903:protein phosphatase binding 0005021:vascular endothelial growth factor-activated receptor activity 0070374:positive regulation of ERK1 and ERK2 cascade 0005576:extracellular region 0043235:receptor complex 0010595:positive regulation of endothelial cell migration 0005886:plasma membrane 0046777:protein autophosphorylation 0060312:regulation of blood vessel remodeling 0001945:lymph vessel development 0048010:vascular endothelial growth factor receptor signaling pathway 0005887:integral component of plasma membrane 0008284:positive regulation of cell population proliferation 0010575:positive regulation of vascular endothelial growth factor production 0001944:vasculature development 0048286:lung alveolus development 0035924:cellular response to vascular endothelial growth factor stimulus 0048514:blood vessel morphogenesis
PDB	4BSJ ; 4BSK
Drugbank	DB06626 ; DB06101 ; DB00398 ; DB01268 ; DB05075 ; DB05932 ; DB04879 ; DB08896 ; DB09079 ; DB09078 ; DB12010 ; DB15685 ; DB06080 ; DB06589
KEGG	hsa:2324

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0540	Tian Ji Huang	田基黄	all - grass of japanese st. johnswort	Grangea maderaspatana
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H1026	Fan Hun Cao	返魂草	Tatarian aster	Aster tataricus
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0853	Zi Wan	紫菀	Tatarion aster	Aster tataricus
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1223	Huai Hun Cao	还魂草	NA	Aster tataricus
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H1184	Bai Lian	白蔹	Japanese ampelopsis	Ampelopsis japonica
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0110	Ku Mu	苦木	Indian quassiawood	Picrasma quassioides
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0450	Shi Chang Pu	石菖蒲	Grassleaved sweetflag	Acorus tatarinowii
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0102	Jue Ming Zi	决明子	Sickle senna seed	Cassia tora
H1100	Gu Jing Cao	谷精草	Pipewart	Eriocaulon buergerianum
H1235	Huang Hao	黄蒿	Virg ate wormwood	Artemisia scoparia
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H0430	She Chuang Zi	蛇床子	Common cnidium	Cnidium monnieri
H0250	Mi Zi Wan	蜜紫菀	Tatarian aster	Aster tataricus
H0451	Shi Chang Pu Jin Gao	石菖蒲浸膏	Grassleaved sweetflag	Acorus tatarinowii
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0689	Xue Feng Teng	血风藤	NA	Ventilago leiocarpa
H0298	Niu Xi Xi	牛西西	Patience dock	Rumex patientia
H0452	Shi Chang Pu Qing Gao	石菖蒲清膏	Grassleaved sweetflag	Acorus tatarinowii
H1000	Dong Gua Zi	冬瓜子	Chinese waxgourd seed	Benincasa hispida
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1011	Bai Chou	白丑	Pharbitis seed	Semen pharbitidis
H0056	Jin Qiao Mai	金荞麦	Wild buckwheat rhizome	Rhizoma fagopyri cymosi
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H1173	Hei Chou	黑丑	Pharbitis seed	Semen pharbitidis
H0998	Dong Gua Pi	冬瓜皮	Chinese waxgourd peel	Benincasa hispida
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 41)