HIT-result

Target Description

Type	Detail
Target ID	T29C64
Protein Name	Calcitonin gene-related peptide 1
Uniprot ID	P06881 ; P01258
Protein Name Alias	NA
Gene ID	796
Gene Symbol	CALCA
Gene Alias	CALC1
TTD	T93509: Clinical Trial target
Pfam	PF00214
GO	0001878:response to yeast 0042802:identical protein binding 0005634:nucleus 0007568:aging 0097647:amylin receptor signaling pathway 0050829:defense response to Gram-negative bacterium 0007218:neuropeptide signaling pathway 0045776:negative regulation of blood pressure 0001944:vasculature development 0007631:feeding behavior 0032730:positive regulation of interleukin-1 alpha production 0031716:calcitonin receptor binding 1990090:cellular response to nerve growth factor stimulus 0001976:nervous system process involved in regulation of systemic arterial blood pressure 0007204:positive regulation of cytosolic calcium ion concentration 0043542:endothelial cell migration 0001935:endothelial cell proliferation 0032147:activation of protein kinase activity 0030279:negative regulation of ossification 0045892:negative regulation of transcription, DNA-templated 1990408:calcitonin gene-related peptide receptor signaling pathway 0051480:regulation of cytosolic calcium ion concentration 0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway 0019732:antifungal humoral response 0031623:receptor internalization 0005615:extracellular space 0042311:vasodilation 0045671:negative regulation of osteoclast differentiation 0044877:protein-containing complex binding 0045986:negative regulation of smooth muscle contraction 0010523:negative regulation of calcium ion transport into cytosol 0002862:negative regulation of inflammatory response to antigenic stimulus 0071356:cellular response to tumor necrosis factor 0002031:G protein-coupled receptor internalization 0005179:hormone activity 0009408:response to heat 0043195:terminal bouton 0007190:activation of adenylate cyclase activity 0001984:artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure 0002548:monocyte chemotaxis 0008016:regulation of heart contraction 0007267:cell-cell signaling 1990000:amyloid fibril formation 0048265:response to pain 0045651:positive regulation of macrophage differentiation 0006954:inflammatory response 0051482:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 0032757:positive regulation of interleukin-8 production 0006468:protein phosphorylation 0005576:extracellular region 0005102:signaling receptor binding 0007159:leukocyte cell-cell adhesion 0005737:cytoplasm 0050830:defense response to Gram-positive bacterium 0007186:G protein-coupled receptor signaling pathway 0007566:embryo implantation 0061844:antimicrobial humoral immune response mediated by antimicrobial peptide 0043025:neuronal cell body 0008217:regulation of blood pressure 0050965:detection of temperature stimulus involved in sensory perception of pain 0019731:antibacterial humoral response 0045779:negative regulation of bone resorption 0045087:innate immune response
PDB	2JXZ ; 1LS7 ; 6E3Y
Drugbank	DB12228 ; DB14042 ; DB14040 ; DB14041 ; DB04869
KEGG	hsa:796

Type

Detail

Target ID

T29C64

Protein Name

Calcitonin gene-related peptide 1

Uniprot ID

P06881
; P01258

Protein Name Alias

Gene ID

796

Gene Symbol

CALCA

Gene Alias

CALC1

TTD

T93509: Clinical Trial target

Pfam

PF00214

0001878:response to yeast

0042802:identical protein binding

0005634:nucleus

0007568:aging

0097647:amylin receptor signaling pathway

0050829:defense response to Gram-negative bacterium

0007218:neuropeptide signaling pathway

0045776:negative regulation of blood pressure

0001944:vasculature development

0007631:feeding behavior

0032730:positive regulation of interleukin-1 alpha production

0031716:calcitonin receptor binding

1990090:cellular response to nerve growth factor stimulus

0001976:nervous system process involved in regulation of systemic arterial blood pressure

0007204:positive regulation of cytosolic calcium ion concentration

0043542:endothelial cell migration

0001935:endothelial cell proliferation

0032147:activation of protein kinase activity

0030279:negative regulation of ossification

0045892:negative regulation of transcription, DNA-templated

1990408:calcitonin gene-related peptide receptor signaling pathway

0051480:regulation of cytosolic calcium ion concentration

0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway

0019732:antifungal humoral response

0031623:receptor internalization

0005615:extracellular space

0042311:vasodilation

0045671:negative regulation of osteoclast differentiation

0044877:protein-containing complex binding

0045986:negative regulation of smooth muscle contraction

0010523:negative regulation of calcium ion transport into cytosol

0002862:negative regulation of inflammatory response to antigenic stimulus

0071356:cellular response to tumor necrosis factor

0002031:G protein-coupled receptor internalization

0005179:hormone activity

0009408:response to heat

0043195:terminal bouton

0007190:activation of adenylate cyclase activity

0001984:artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure

0002548:monocyte chemotaxis

0008016:regulation of heart contraction

0007267:cell-cell signaling

1990000:amyloid fibril formation

0048265:response to pain

0045651:positive regulation of macrophage differentiation

0006954:inflammatory response

0051482:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

0032757:positive regulation of interleukin-8 production

0006468:protein phosphorylation

0005576:extracellular region

0005102:signaling receptor binding

0007159:leukocyte cell-cell adhesion

0005737:cytoplasm

0050830:defense response to Gram-positive bacterium

0007186:G protein-coupled receptor signaling pathway

0007566:embryo implantation

0061844:antimicrobial humoral immune response mediated by antimicrobial peptide

0043025:neuronal cell body

0008217:regulation of blood pressure

0050965:detection of temperature stimulus involved in sensory perception of pain

0019731:antibacterial humoral response

0045779:negative regulation of bone resorption

0045087:innate immune response

PDB

2JXZ ; 1LS7 ; 6E3Y

Drugbank

DB12228 ; DB14042 ; DB14040 ; DB14041 ; DB04869

KEGG

hsa:796

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0616	Wu Zhu Yu	吴茱萸	Medicinal evodia	Evodia rutaecarpa
H0854	Zi Wei Gen Pi	紫葳根皮	NA	Campsis grandiflora
H0123	La Jiao Liu Jin Gao	辣椒流浸膏	Bush redpepper	Capsicum frutescens
H0458	Shi Hu	石斛	Dendrobium	Herba dendrobii
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0242	Bei Sha Shen Liu Jin Gao	北沙参流浸膏	Glehnia littoralis	Glehnia littoralis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1115	Guan Huang Bai	关黄柏	Amur cork tree	Phellodendron amurense
H1228	Huang Bai	黄柏	Amur corktree	Phellodendron amurense
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H0704	Yan Guan Huang Bai	盐关黄柏	Amur cork tree	Phellodendron amurense
H0119	La Jiao	辣椒	Bush redpepper	Capsicum frutescens
H1231	Huang Bai Tan	黄柏炭	Amur corktree	Phellodendron amurense
H0121	La Jiao Jin Chu Ye	辣椒浸出液	Bush redpepper	Capsicum frutescens
H0122	La Jiao Jin Gao	辣椒浸膏	Bush redpepper	Capsicum frutescens
H0239	Bei Sha Shen	北沙参	Coastal glehnia	Glehnia littoralis
H1230	Huang Bai Fen	黄柏粉	Amur corktree	Phellodendron amurense
H0295	Bi Ba	荜茇	Long pepper	Piper longum

Target Description

Related Compounds (Total: 6)

Related Herbs (Total: 18)