Target Description

Type Detail
Target ID T22H7B
Protein Name Neuronal acetylcholine receptor subunit alpha-4
Uniprot ID P43681
Protein Name Alias NA
Gene ID 1137
Gene Symbol CHRNA4
Gene Alias NACRA4
TTD T70967: Successful target
Pfam PF02931 ; PF02932
GO
0007271:synaptic transmission, cholinergic

0045202:synapse

0022848:acetylcholine-gated cation-selective channel activity

0030594:neurotransmitter receptor activity

0007268:chemical synaptic transmission

0016020:membrane

0042391:regulation of membrane potential

0030425:dendrite

0001666:response to hypoxia

0006811:ion transport

0035094:response to nicotine

0050890:cognition

0005886:plasma membrane

0016021:integral component of membrane

0005892:acetylcholine-gated channel complex

0019233:sensory perception of pain

0042166:acetylcholine binding

0043025:neuronal cell body

0060080:inhibitory postsynaptic potential

0015276:ligand-gated ion channel activity

0035095:behavioral response to nicotine

0043005:neuron projection

0015464:acetylcholine receptor activity

0034220:ion transmembrane transport

0045211:postsynaptic membrane

0007165:signal transduction

0051899:membrane depolarization

0014059:regulation of dopamine secretion

0006816:calcium ion transport

0042113:B cell activation

0009897:external side of plasma membrane

0005887:integral component of plasma membrane

0050877:nervous system process

0006979:response to oxidative stress

0001508:action potential

0006281:DNA repair

PDB 6USF ; 2GVT ; 6CNJ ; 6CNK ; 5KXI ; 2LLY ; 6UR8
Drugbank DB01483 ; DB01245 ; DB00783 ; DB00981 ; DB05458 ; DB00572 ; DB13956 ; DB00564 ; DB13954 ; DB07720 ; DB00898 ; DB00312 ; DB01174 ; DB05740 ; DB00753 ; DB00747 ; DB00333 ; DB00184 ; DB01273 ; DB01351 ; DB13953 ; DB00915 ; DB00514 ; DB01355 ; DB00794 ; DB13952 ; DB00657 ; DB13955 ; DB00241 ; DB01354 ; DB01352 ; DB01496 ; DB00463 ; DB00306 ; DB00418 ; DB00599 ; DB00237 ; DB00849 ; DB01353 ; DB09028
KEGG hsa:1137

Related Compounds  (Total: 8)

Go to browser
C0233
Name: (-)-Lobeline
Go to browser
C0247
Name: Nicotine
Go to browser
C0465
Name: Tubocurarine
Go to browser
C0606
Name: Choline
Go to browser
C0854
Name: Acetylcholine


Related Herbs  (Total: 85)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H0713 Che Qian Cao车前草 all-grass of rippleseed plantainPlantago depressa
H0802 Zhi Geng枳梗 NACitrus aurantium
H0043 Jie Zi芥子 India mustard seedBrassica juncea
H0357 Ren Shen人参 GinsengPanax ginseng
H0818 Zhi Zi栀子 Cape jasmine fruitGardenia jasminoides
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H0615 Wu Zhi Mao Tao五指毛桃 five-finger fig rootFicus simplicissima
H0424 Shan Zhi山栀 Cape jasmineGardenia jasminoides
H0029 Jiang Huang Lian姜黄连 Coptis deltoideaCoptis chinensis
H0813 Zhi Shi枳实 Seville orange young fruitCitrus aurantium
H0115 Kuan Dong Hua款冬花 Common coltsfootTussilago farfara
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0659 Chai Hu Jin Gao柴胡浸膏 Chinese thorowaxBupleurum chinense
H1193 Hou Er Huan Gan Jin Gao猴耳环干浸膏 NAPithecellobium clypearia
H1040 Feng Mi蜂蜜 HoneyApis cerana
H1212 Hu Ye Gan Jin Gao槲叶干浸膏 NAQuercus dentata
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H0920 Da Ban Bian Lian大半边莲 Asian lobeliaLobelia chinensis
H1133 Gui Jian Yu鬼箭羽 Winged euonymusEuonymus alatus
H0500 Can Yong蚕蛹 Silkworm chrysalisBombyx mori
H0244 Mi La蜜蜡 Bee waxApis cerana
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H0522 Tai Zi Shen太子参 Heterophylly falsestarwort rootRadix pseudostellariae
H1194 Hou Er Huan Jin Gao猴耳环浸膏 NAPithecellobium clypearia
H0243 Mi Kuan Dong Hua蜜款冬花 Common coltsfootTussilago farfara
H0785 Ze Xi Huang Lian择细黄连 Coptis deltoideaCoptis chinensis
H1176 Hei Hu Jiao黑胡椒 Black pepperPiper nigrum
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0129 Le Xian Cai勒苋菜 NAAmaranthus spinosus
H1231 Huang Bai Tan黄柏炭 Amur corktreePhellodendron amurense
H0256 Ming Dang Shen明党参 Medicinal changiumChangium smyrnioides
H1242 Huang Lian Gan Jin Gao黄连干浸膏 Coptis deltoideaCoptis chinensis
H0665 Chai Hu Shao柴胡梢 Chinese thorowaxBupleurum chinense
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H1077 Bai Hu Jiao白胡椒 white pepperPiper nigrum
H0805 Zhi Ke Gan Jin Gao枳壳干浸膏 Seville ora nge unripe fruitCitrus aurantium
H0961 Dang Yao当药 Chinese swertiaSwertia chinensis
H0248 Mi Ying Su Ke蜜罂粟壳 Opium poppyPapaver somniferum
H0819 Zhi Zi Jin Gao栀子浸膏 Cape jasmine fruitGardenia jasminoides
H1204 Hu Jiao胡椒 Black pepperPiper nigrum
H0903 Ci Cai荠菜 ShepherdspurseCapsella bursa-pastoris
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0760 Yu Huang Lian萸黄连 Coptis deltoideaCoptis chinensis
H0757 Ying Su Ke罂粟壳 Opium poppy pericarpPapaver somniferum
H0702 Yan Bai Cai岩白菜 Purple bergeniaBergenia purpurascens
H0682 Xiong Huang Lian雄黄连 Coptis deltoideaCoptis chinensis
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0872 Chuan Huang Lian川黄连 rhizome of chinese goldthreadCoptis chinensis
H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H1243 Huang Lian Xu黄连须 Coptis deltoideaCoptis chinensis
H0714 Yan Tai Chai Hu烟台柴胡 Chinese thorowaxBupleurum chinense
H1241 Huang Lian黄连 Coptis deltoideaCoptis chinensis
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0758 Cheng Pi橙皮 Bitter orangeCitrus aurantium
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H0082 Jiu Huang Lian酒黄连 Coptis deltoideaCoptis chinensis
H1115 Guan Huang Bai关黄柏 Amur cork treePhellodendron amurense
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0006 Bai Qu Cai白屈菜 Greater celandineChelidonium majus
H1230 Huang Bai Fen黄柏粉 Amur corktreePhellodendron amurense
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0938 Da Suan大蒜 GarlicAllium sativum
H0704 Yan Guan Huang Bai盐关黄柏 Amur cork treePhellodendron amurense
H0906 Ci Wan刺苋 spiny amaranthAmaranthus spinosus
H0650 Chai Hu柴胡 Chinese thorowaxBupleurum chinense
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H1228 Huang Bai黄柏 Amur corktreePhellodendron amurense
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H1039 Bai Fu Zi白附子 Korean monkshood rootTyphonium giganteum
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H1192 Hou Er Huan猴耳环 NAPithecellobium clypearia
H0113 Ban Bian Lian半边莲 Chinese lobeliaLobelia chinensis
H0476 Can E蚕蛾 SilkwormBombyx mori
H0416 Shan Shen山参 NAPanax ginseng
H0756 Ying Su罂粟 Opium poppyPapaver somniferum
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H0204 Ma Ren麻仁 NACannabis sativa