Target Description
| Type | Detail |
|---|---|
| Target ID | T74P7I |
| Protein Name | G-protein coupled bile acid receptor 1 |
| Uniprot ID |
Q8TDU6 |
| Protein Name Alias | G-protein coupled receptor GPCR19; hGPCR19; Membrane-type receptor for bile acids; M-BAR; hBG37; BG37 |
| Gene ID |
151306 |
| Gene Symbol | GPBAR1 |
| Gene Alias | TGR5 |
| TTD | T86273: Clinical Trial target |
| Pfam | PF00001 |
| GO |
1903413:cellular response to bile acid
1904056:positive regulation of cholangiocyte proliferation 0070374:positive regulation of ERK1 and ERK2 cascade 0038181:bile acid receptor activity 0016021:integral component of membrane 0007186:G protein-coupled receptor signaling pathway 2000810:regulation of bicellular tight junction assembly 0002862:negative regulation of inflammatory response to antigenic stimulus 0038182:G protein-coupled bile acid receptor activity 0038184:cell surface bile acid receptor signaling pathway 0043235:receptor complex 0005886:plasma membrane 0005737:cytoplasm |
| PDB | 7CFM ; 7CFN ; 7BW0 |
| Drugbank | DB03619 ; DB02659 ; DB06777 |
| KEGG | hsa:151306 |
Related Compounds (Total: 13)
C0006
Name: Deoxycholic Acid
C0194
Name: Lithocholic Acid
C0257
Name: Obacunone
C0432
Name: Taurolithocholic Acid
C0474
Name: Ursocholanic Acid
Related Herbs (Total: 140)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0648 | Xiang Si Teng | 相思藤 | Coralhead plant vine | Abrus precatorius |
| H0609 | Wu Wei Zi Liu Jin Gao | 五味子流浸膏 | Five-flavor berry | Schisandra chinensis |
| H0713 | Che Qian Cao | 车前草 | all-grass of rippleseed plantain | Plantago depressa |
| H0308 | Pi Ba Ren | 枇杷仁 | NA | Eriobotrya japonica |
| H0605 | Wu Wei Zi | 五味子 | Chinese magnoliavine | Schisandra chinensis |
| H0832 | Zhu Sha Gen | 朱砂根 | Coral ardisia | Ardisia crenata |
| H0357 | Ren Shen | 人参 | Ginseng | Panax ginseng |
| H0419 | Shan Zha | 山楂 | Chinese hawthorn | Crataegus pinnatifida |
| H0336 | Qin Jiao | 秦艽 | large-leaved gentian | Gentiana macrophylla |
| H0854 | Zi Wei Gen Pi | 紫葳根皮 | NA | Campsis grandiflora |
| H0727 | Ye Gan Cao | 野甘草 | Sweet broomwort | Scoparia dulcis |
| H0302 | Ou Fen | 藕粉 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0292 | Niu Jiao Jian Fen | 牛角尖粉 | Buffalo horn | Bubalus bubalis |
| H0142 | Liang Jiang | 良姜 | NA | Alpinia officinarum |
| H0780 | Zao Pi | 枣皮 | Varieties | Ziziphus jujuba mill. var. inermis (bge.) rehd. |
| H0170 | Lu Bian Qing | 路边青 | Manyflower glorybower leaf | Clerodendron cyrtophyllum |
| H0637 | Cha Ye | 茶叶 | Common tea | Camellia sinensis |
| H0016 | Ji Xue Cao | 积雪草 | Asiatic pennywort | Centella asiatica |
| H0989 | Ding Kui Cao | 丁葵草 | Herb of twinleaf zornia | Kummerowia striata |
| H0431 | She Dan Zhi | 蛇胆汁 | Snake bile | Fel serpentis liquidum |
| H0461 | Shi Jun Zi Ren | 使君子仁 | NA | Combretum indicum |
| H0967 | Di Er Cao | 地耳草 | Japanese stJohn’swort | Hypericum japonicum |
| H0570 | Tu Fu Ling | 土茯苓 | Glabrous greenbrier | Smilax glabra |
| H0089 | Ju Hong | 橘红 | NA | Citri exocarpium rubrum |
| H0607 | Wu Wei Zi Jin Chu Wu | 五味子浸出物 | Five-flavor berry | Schisandra chinensis |
| H0631 | Xi Yang Shen | 西洋参 | American ginseng | Panax quinquefolium |
| H0537 | Tian Dong | 天冬 | Cochinchinese asparagus root | Asparagus cochinchinensis |
| H0462 | Shi Liu | 石榴 | Pomegranate fruit | Punica granatum |
| H0293 | Niu Jiao Tan | 牛角炭 | Buffalo horn | Bubalus bubalis |
| H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
| H0258 | Mo Han Lian | 墨旱莲 | Yerbadetajo | Eclipta prostrata |
| H0638 | Xiang Bei | 象贝 | Fritillaria | Fritillaria thunbergii |
| H0269 | Mu Gua | 木瓜 | Chinese floweringquince | Chaenomeles sinensis |
| H0972 | Di Huang | 地黄 | Rehmanniae | Rehmannia glutinosa |
| H0591 | Wei Ling Cai | 委陵菜 | Chinese cinquefoil | Potentilla chinensis |
| H0470 | Shi Ye | 柿叶 | Persimmon leaf | Diospyros kaki |
| H0693 | Xue Xie | 血蝎 | Dragon's blood | Daemonorops draco |
| H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
| H0855 | Chuan Bei Mu | 川贝母 | Fritillaria unibracteata | Fritillaria cirrhosa |
| H0216 | Man Jing Ye | 蔓荆叶 | Threeleaf chastetree leaf | Vitex trifolia |
| H1247 | Huang Qi | 黄芪 | Membranous milkvetch | Astragalus membranaceus |
| H0747 | An Xi Xiang | 安息香 | Sumatra snowbel | Styrax benzoin |
| H0968 | Di Feng Pi | 地枫皮 | Difengpi anisetree | Illicium difengpi |
| H0488 | Shui Niu Jiao Gan Jin Gao | 水牛角干浸膏 | Buffalo horn | Bubalus bubalis |
| H0327 | Qian Li Guang | 千里光 | Climbing groundsel | Senecio scandens |
| H1179 | Hei Mian Shen | 黑面神 | Leaf and twig of fruticose breynia | Breynia fruticosa |
| H0069 | Jin Ying Zi Ti Qu Ye | 金樱子提取液 | Cherokee rose seed | Rosa laevigata |
| H0951 | Dan Shen Jin Gao | 丹参浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0229 | Mao Da Ding Cao | 毛大丁草 | Pilose gerbera | Gerbera piloselloides |
| H0604 | Wu Wei Teng | 五味藤 | NA | Securidaca inappendiculata |
| H0331 | Qiang Huo | 羌活 | Incised notopterygium | Notopterygium incisum |
| H0060 | Jin Si Ku Lian | 金丝苦楝 | NA | Cardiospermum halicacabum |
| H0463 | Shi Liu Pi | 石榴皮 | Pomegranate peel | Punica granatum |
| H0141 | Lian Zi Xin | 莲子心 | Hindu lotus plumule | Nelumbo nucifera |
| H0468 | Shi Wei | 石韦 | Japanese felt fern frond | Pyrrosia lingua |
| H0162 | Long Dan | 龙胆 | Rough gentian | Gentiana scabra |
| H1030 | Fang Feng | 防风 | Divaricate saposhnikovia | Saposhnikovia divaricata |
| H0173 | Lu Hui | 芦荟 | Kulaso aloe dried juice | Aloe vera |
| H0652 | Xiang Yuan Pi | 香橼皮 | Wilson citron | Citrus medica |
| H0515 | Suan Shi Liu | 酸石榴 | Pomegranate | Punica granatum |
| H0304 | Ou Pian | 藕片 | Hindu lotus large rhizome | Nelumbo nucifera |
| H1231 | Huang Bai Tan | 黄柏炭 | Amur corktree | Phellodendron amurense |
| H0278 | Nan Ban Lan Gen Jin Gao Fen | 南板蓝根浸膏粉 | Indigowoad root | Baphicacanthus cusia |
| H0067 | Jin Ying Zi | 金樱子 | Cherokee rose seed | Rosa laevigata |
| H1251 | Huang Qin | 黄芩 | Root of Baikal skullcaap | Scutellaria baicalensis |
| H0230 | Mao Dong Qing | 毛冬青 | Pubescent holly | Ilex pubescens |
| H0427 | Shan Zhu Yu | 山茱萸 | Asiatic cornelian cherry | Cornus officinalis |
| H0140 | Lian Zi | 莲子 | Hindu lotus seed | Nelumbo nucifera |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H0949 | Dan Shen | 丹参 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H1186 | Hong Gen Cao | 红根草 | Hispid sage | Salvia prionitis |
| H0614 | Wu Zhao Long | 五爪龙 | Cairo morningglory | Ipomoea cairica |
| H1203 | Hu Ji Sheng | 槲寄生 | Colored mistletoe | Viscum coloratum |
| H1205 | Hu Lu Cha | 葫芦茶 | Triquetrous tadehagi | Tadehagi triquetrum |
| H0656 | Xiao Bo Gen | 小檗根 | Barberry root | Berberis julianae |
| H0715 | Che Qian Zi | 车前子 | seed of asiatic pantain | Plantago asiatica |
| H0137 | Ban Lan Gen | 板蓝根 | Indigowoad root | Isatis indigotica |
| H0237 | Mei Gui Hua | 玫瑰花 | Rugose rose flower | Rosa rugosa |
| H0020 | Ji Yan Cao | 鸡眼草 | Striate kummerowia | Kummerowia striata |
| H1016 | Du Zhong Tan | 杜仲炭 | Eucommia | Eucommia ulmoides |
| H1093 | Gao Liang Jiang You | 高良姜油 | Lesser galangal | Alpinia officinarum |
| H0940 | Da Ye Zi Zhu | 大叶紫珠 | Bigleaf beautyberry | Callicarpa macrophylla |
| H0908 | Ci Wu Jia | 刺五加 | Manypr ickle acanthopana x | Eleutherococcus senticosus |
| H1017 | Du Zhong Ye | 杜仲叶 | Eucommia leaf | Eucommia ulmoides |
| H0085 | Jiu Yu Rou | 酒萸肉 | Asiatic cornelian cherry | Cornus officinalis |
| H0829 | Zhu Jie Xiang Fu | 竹节香附 | rhizome of radde anemone | Anemone raddeana |
| H0093 | Ju Pi | 橘皮 | Tangerine pericarp | Citrus reticulata |
| H0464 | Shi Liu Zi | 石榴子 | NA | Punica granatum |
| H1240 | Huang Jing Zi | 黄荆子 | NA | Vitex negundo |
| H0370 | Ru Xiang | 乳香 | Olibanum | Boswellia carterii |
| H0971 | Bai Bian Dou | 白扁豆 | White hyacinth bean | Lablab purpureus |
| H1229 | Bai Mu Xiang | 白木香 | Chinese eaglewood | Aquilaria sinensis |
| H0361 | Ren Zi Cao | 人字草 | Herb of twinleaf zornia | Kummerowia striata |
| H1163 | He Bao Cao | 荷包草 | NA | Lamprocapnos spectabilis |
| H0489 | Shui Niu Jiao Nong Suo Fen | 水牛角浓缩粉 | Buffalo horn | Bubalus bubalis |
| H0487 | Shui Niu Jiao | 水牛角 | Buffalo horn | Bubalus bubalis |
| H0453 | Shi Di | 柿蒂 | Persimmon persistent calyx | Diospyros kaki |
| H0801 | Chong Bai La | 虫白蜡 | Cera chinensis wax | Ericerus pela |
| H0950 | Dan Shen Gan Jin Gao | 丹参干浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H1015 | Du Zhong | 杜仲 | Eucommia | Eucommia ulmoides |
| H0277 | Nan Ban Lan Gen | 南板蓝根 | Indigowoad root | Baphicacanthus cusia |
| H0937 | Da Qing Ye | 大青叶 | Indigo-coloured woad leaf | Isatis indigotica |
| H1115 | Guan Huang Bai | 关黄柏 | Amur cork tree | Phellodendron amurense |
| H0606 | Wu Wei Zi Chun Jin Gao | 五味子醇浸膏 | Five-flavor berry | Schisandra chinensis |
| H0006 | Bai Qu Cai | 白屈菜 | Greater celandine | Chelidonium majus |
| H0217 | Man Jing Zi | 蔓荆子 | Threeleaf chastetree fruit | Vitex trifolia |
| H1230 | Huang Bai Fen | 黄柏粉 | Amur corktree | Phellodendron amurense |
| H0088 | Ju He | 橘核 | Tangerine seed | Citrus reticulata |
| H0168 | Long Yan Rou | 龙眼肉 | Longan aril | Arillus longan |
| H0408 | Bing Lang | 槟榔 | Betenutpalm | Areca catechu |
| H0160 | Liu Zhi | 柳枝 | Babylon weeping willow branch | Salix babylonica |
| H0496 | Shui Ze Lan | 水泽兰 | NA | Lycopus lucidus |
| H0068 | Jin Ying Zi Rou | 金樱子肉 | Cherokee rose seed | Rosa laevigata |
| H1004 | Bai Cha | 白茶 | White tea | Camellia sinensis |
| H0608 | Wu Wei Zi Jin Gao | 五味子浸膏 | Five-flavor berry | Schisandra chinensis |
| H0651 | Xiang Yuan | 香橼 | Wilson citron | Citrus medica |
| H0035 | Bai Su Zi | 白苏子 | Common perilla fruit | Perilla frutescens |
| H0704 | Yan Guan Huang Bai | 盐关黄柏 | Amur cork tree | Phellodendron amurense |
| H0139 | Lian Qiao | 连翘 | Weeping forsythia | Forsythia suspensa |
| H0195 | Ma Chi Xian | 马齿苋 | Purslane | Portulaca oleracea |
| H0542 | Tian Ma | 天麻 | Tall gastrodia | Gastrodia elata |
| H1164 | He Geng | 荷梗 | Hindu lotus petiole | Nelumbo nucifera |
| H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
| H1211 | Bai Mei | 白眉 | pilose gerbera herb | Gerbera piloselloides |
| H1200 | Bai Mao Gen | 白茅根 | Lalang grass rhizome | Imperata cylindrica |
| H0301 | Ou | 藕 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0941 | Da Zao | 大枣 | Chinese date | Ziziphus jujuba |
| H0523 | Cang Er Zi | 苍耳子 | fruit of siberian cockleblur | Fructus xanthii sibirici |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H0564 | Tu Bei Mu | 土贝母 | Paniculate bolbostemma | Rhizoma bolbostemmae |
| H1228 | Huang Bai | 黄柏 | Amur corktree | Phellodendron amurense |
| H0158 | Liu Ling Ju | 六棱菊 | NA | Laggera alata |
| H0946 | A Wei | 阿魏 | Asafetida giantfennel resin | Ferula assafoetida |
| H1117 | Guan Zhong | 贯众 | Male fern rhizome | Dryopteris crassirhizoma |
| H1056 | Fu Pen Zi | 覆盆子 | Red-and-Yellow garden raspberry | Rubus idaeus |
| H1092 | Gao Liang Jiang | 高良姜 | Lesser galangal | Alpinia officinarum |
| H1169 | He Ye | 荷叶 | Hindu lotus leaf | Nelumbo nucifera |
| H0775 | Yun Zhi | 云芝 | Coriolus versicolor | Polysaccharidum versicolor |
| H0649 | Xiang Si Zi | 相思子 | Coralhead plant | Abrus precatorius |
| H0291 | Niu Jiao Fen | 牛角粉 | Buffalo horn | Bubalus bubalis |