HIT-result

Type	Detail
Target ID	T63EMC
Protein Name	Interleukin-18
Uniprot ID	Q14116
Protein Name Alias	IL-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma
Gene ID	3606
Gene Symbol	IL18
Gene Alias	IGIF; IL1F4
TTD	T06671: Clinical Trial target
Pfam	PF00340
GO	0005829:cytosol 0001525:angiogenesis 0019221:cytokine-mediated signaling pathway 0035590:purinergic nucleotide receptor signaling pathway 0030431:sleep 0031663:lipopolysaccharide-mediated signaling pathway 0048661:positive regulation of smooth muscle cell proliferation 0051142:positive regulation of NK T cell proliferation 0050729:positive regulation of inflammatory response 0030155:regulation of cell adhesion 0032819:positive regulation of natural killer cell proliferation 0006954:inflammatory response 0045515:interleukin-18 receptor binding 0005615:extracellular space 0005125:cytokine activity 0045944:positive regulation of transcription by RNA polymerase II 0032740:positive regulation of interleukin-17 production 0032729:positive regulation of interferon-gamma production 0070328:triglyceride homeostasis 0032736:positive regulation of interleukin-13 production 0035655:interleukin-18-mediated signaling pathway 0000165:MAPK cascade 0042632:cholesterol homeostasis 0120162:positive regulation of cold-induced thermogenesis 0042088:T-helper 1 type immune response 0071407:cellular response to organic cyclic compound 0010744:positive regulation of macrophage derived foam cell differentiation 0030101:natural killer cell activation 0045630:positive regulation of T-helper 2 cell differentiation 0005576:extracellular region 0042092:type 2 immune response 0008283:cell population proliferation 0042119:neutrophil activation 0045662:negative regulation of myoblast differentiation 0014068:positive regulation of phosphatidylinositol 3-kinase signaling 0042104:positive regulation of activated T cell proliferation 0051897:positive regulation of protein kinase B signaling 0034105:positive regulation of tissue remodeling 0051092:positive regulation of NF-kappaB transcription factor activity 0007267:cell-cell signaling 0042531:positive regulation of tyrosine phosphorylation of STAT protein 0032148:activation of protein kinase B activity 0150078:positive regulation of neuroinflammatory response 0032722:positive regulation of chemokine production 0042267:natural killer cell mediated cytotoxicity 2000556:positive regulation of T-helper 1 cell cytokine production 1901224:positive regulation of NIK/NF-kappaB signaling 0032725:positive regulation of granulocyte macrophage colony-stimulating factor production
PDB	3WO2 ; 2VXT ; 3WO3 ; 4XFT ; 4EKX ; 4XFS ; 4HJJ ; 4XFU ; 1J0S ; 4R6U ; 3F62 ; 4EEE ; 3WO4
Drugbank	NA
KEGG	hsa:3606

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Name: Phorbol Myristate Acetate

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Name: Progesterone

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Name: Schisandrin B

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Name: Alcohol

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Name: Atorvastatin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0610	Wu Xiang Xue Teng	五香血藤	longpeduncle kadsura stem	Schisandra sphenanthera
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H0607	Wu Wei Zi Jin Chu Wu	五味子浸出物	Five-flavor berry	Schisandra chinensis
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H1168	He Tao Ren	核桃仁	English walnut seed	Semen juglandis
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0956	Dang Gui Gan Jin Gao	当归干浸膏	NA	Angelica sinensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
H0605	Wu Wei Zi	五味子	Chinese magnoliavine	Schisandra chinensis
H0522	Tai Zi Shen	太子参	Heterophylly falsestarwort root	Radix pseudostellariae
H0606	Wu Wei Zi Chun Jin Gao	五味子醇浸膏	Five-flavor berry	Schisandra chinensis
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0888	Ba Dou Ye	巴豆叶	Pu rging croton	Croton tiglium
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0955	Dang Gui	当归	Chinese angelica	Angelica sinensis
H0869	Ba Dou	巴豆	Pu rging croton	Croton tiglium
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H1167	He Tao	核桃	English walnut seed	Semen juglandis
H0609	Wu Wei Zi Liu Jin Gao	五味子流浸膏	Five-flavor berry	Schisandra chinensis
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0262	Bei Wu Wei	北五味	fruit of chinese nmagnoliavine	Rosmarinus officinalis
H0582	Cao Dou Kou Ren	草豆蔻仁	Katsumada galangal	Alpinia katsumadai
H0608	Wu Wei Zi Jin Gao	五味子浸膏	Five-flavor berry	Schisandra chinensis
H0574	Cao Dou Kou	草豆蔻	Katsumada galangal	Alpinia katsumadai
H0416	Shan Shen	山参	NA	Panax ginseng
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0878	Ba Dou Shuang	巴豆霜	Defatted croton seed powder	Croton tiglium

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 34)