HIT-result

Type	Detail
Target ID	T12CH9
Protein Name	Sphingosine 1-phosphate receptor 1
Uniprot ID	P21453
Protein Name Alias	S1P receptor 1; S1P1; Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; CD antigen CD363
Gene ID	1901
Gene Symbol	S1PR1
Gene Alias	CHEDG1; EDG1
TTD	T13852: Successful target
Pfam	PF00001
GO	0007155:cell adhesion 0043547:positive regulation of GTPase activity 0030182:neuron differentiation 0030335:positive regulation of cell migration 0030500:regulation of bone mineralization 0030595:leukocyte chemotaxis 0046625:sphingolipid binding 0019222:regulation of metabolic process 0007420:brain development 0045446:endothelial cell differentiation 0003376:sphingosine-1-phosphate receptor signaling pathway 0001664:G protein-coupled receptor binding 0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway 0005886:plasma membrane 0072678:T cell migration 0043231:intracellular membrane-bounded organelle 0045121:membrane raft 0016021:integral component of membrane 0031226:intrinsic component of plasma membrane 0030032:lamellipodium assembly 0050927:positive regulation of positive chemotaxis 0048661:positive regulation of smooth muscle cell proliferation 0030155:regulation of cell adhesion 0004930:G protein-coupled receptor activity 0019226:transmission of nerve impulse 0051482:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 0031532:actin cytoskeleton reorganization 0003245:cardiac muscle tissue growth involved in heart morphogenesis 0005737:cytoplasm 0051497:negative regulation of stress fiber assembly 0001525:angiogenesis 0038036:sphingosine-1-phosphate receptor activity 0007186:G protein-coupled receptor signaling pathway 0045124:regulation of bone resorption 0016477:cell migration 0005654:nucleoplasm 0006935:chemotaxis 0019221:cytokine-mediated signaling pathway 0007193:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 0001955:blood vessel maturation 0009897:external side of plasma membrane 0045944:positive regulation of transcription by RNA polymerase II 0005768:endosome 0061384:heart trabecula morphogenesis
PDB	3V2W ; 3V2Y
Drugbank	DB09105 ; DB08868 ; DB12612 ; DB12371
KEGG	hsa:1901

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Name: Phorbol Myristate Acetate

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Name: Sphingosine

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1167	He Tao	核桃	English walnut seed	Semen juglandis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0878	Ba Dou Shuang	巴豆霜	Defatted croton seed powder	Croton tiglium
H0869	Ba Dou	巴豆	Pu rging croton	Croton tiglium
H1168	He Tao Ren	核桃仁	English walnut seed	Semen juglandis
H0574	Cao Dou Kou	草豆蔻	Katsumada galangal	Alpinia katsumadai
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0004	Huo Xiang	藿香	Patchouli	Pogostemon cablin
H0005	Huo Xiang Ye	藿香叶	Patchouli	Pogostemon cablin
H0582	Cao Dou Kou Ren	草豆蔻仁	Katsumada galangal	Alpinia katsumadai
H0888	Ba Dou Ye	巴豆叶	Pu rging croton	Croton tiglium
H1010	Du Huo Xiang	杜藿香	Patchouli	Pogostemon cablin
H0572	Tu Huo Xiang	土藿香	Patchouli	Pogostemon cablin
H1120	Guang Huo Xiang	广藿香	Patchouli	Pogostemon cablin
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum