Target Description

Type Detail
Target ID T95Y0K
Protein Name Sphingosine kinase 1
Uniprot ID Q9NYA1
Protein Name Alias SK 1;  SPK 1;  EC 2.7.1.91;  Acetyltransferase SPHK1;  EC 2.3.1.-
Gene ID 8877
Gene Symbol SPHK1
Gene Alias SK1;  SPHK;  SPK
TTD T86014: Clinical Trial target
Pfam PF00781
GO
1903978:regulation of microglial cell activation

0046521:sphingoid catabolic process

0051721:protein phosphatase 2A binding

0035556:intracellular signal transduction

0030100:regulation of endocytosis

0003951:NAD+ kinase activity

0016407:acetyltransferase activity

0050764:regulation of phagocytosis

0006457:protein folding

0005524:ATP binding

1901224:positive regulation of NIK/NF-kappaB signaling

0048146:positive regulation of fibroblast proliferation

0070301:cellular response to hydrogen peroxide

0035924:cellular response to vascular endothelial growth factor stimulus

0043066:negative regulation of apoptotic process

0016310:phosphorylation

0016020:membrane

0071897:DNA biosynthetic process

0001568:blood vessel development

0007420:brain development

1900745:positive regulation of p38MAPK cascade

0045840:positive regulation of mitotic nuclear division

0005829:cytosol

0045931:positive regulation of mitotic cell cycle

0005905:clathrin-coated pit

0010800:positive regulation of peptidyl-threonine phosphorylation

0005516:calmodulin binding

0030307:positive regulation of cell growth

0001727:lipid kinase activity

0046512:sphingosine biosynthetic process

0031901:early endosome membrane

0030139:endocytic vesicle

0032651:regulation of interleukin-1 beta production

0005886:plasma membrane

0000287:magnesium ion binding

0008289:lipid binding

1900060:negative regulation of ceramide biosynthetic process

0034612:response to tumor necrosis factor

0150077:regulation of neuroinflammatory response

0005737:cytoplasm

0017050:D-erythro-sphingosine kinase activity

0003677:DNA binding

0031398:positive regulation of protein ubiquitination

0030335:positive regulation of cell migration

0045766:positive regulation of angiogenesis

0005634:nucleus

0006665:sphingolipid metabolic process

0071363:cellular response to growth factor stimulus

1905364:regulation of endosomal vesicle fusion

0030148:sphingolipid biosynthetic process

0038036:sphingosine-1-phosphate receptor activity

0006954:inflammatory response

0006670:sphingosine metabolic process

0032740:positive regulation of interleukin-17 production

0008481:sphinganine kinase activity

0098793:presynapse

0043231:intracellular membrane-bounded organelle

0051092:positive regulation of NF-kappaB transcription factor activity

0045987:positive regulation of smooth muscle contraction

0010803:regulation of tumor necrosis factor-mediated signaling pathway

0006473:protein acetylation

0019722:calcium-mediated signaling

PDB 4L02 ; 4V24 ; 3VZD ; 3VZB ; 3VZC
Drugbank DB08868
KEGG hsa:8877

Related Compounds  (Total: 7)

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C0039
Name: Ellagic Acid
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C0113
Name: Guanine
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C0213
Name: Metformin
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C0305
Name: Phorbol Myristate Acetate
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C0325
Name: Progesterone


Related Herbs  (Total: 114)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0357 Ren Shen人参 GinsengPanax ginseng
H0344 Qing Guo青果 OliveCanarium album
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H1025 Fan Bai Cao翻白草 Discolor cinquefoilPotentilla discolor
H0878 Ba Dou Shuang巴豆霜 Defatted croton seed powderCroton tiglium
H1091 Gao Li Shen高丽参 Korea ginsengRadix ginseng korea
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H0345 Qing Guo Tan青果炭 white oliveCanarium album
H0267 Mu Ding Xiang母丁香 Clove fruitFructus caryophylli
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H1035 Bai Fu Ling白茯苓 white indian breadWolfiporia cocos
H0066 Jin Ying Gen金樱根 root of cherokee roseRadix rosae laevigatae
H0288 Niu Bang Cao牛蒡草 greater burdockArctium lappa
H0461 Shi Jun Zi Ren使君子仁 NACombretum indicum
H0967 Di Er Cao地耳草 Japanese stJohn’swortHypericum japonicum
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0784 Chi Shao赤芍 Red peony rootPaeonia obovata
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0311 Ping Bei Mu平贝母 Ussuri fritillaryFritillaria ussuriensis
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H1167 He Tao核桃 English walnut seedSemen juglandis
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H0429 Shao Yao芍药 Red peony rootPaeonia obovata
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H1009 Du Huo独活 Doubleteeth pubescent angelicaAngelica pubescens
H1130 Guang Zao广枣 fruit of axillary choerospondiasFructus choerospondiatis
H0638 Xiang Bei象贝 FritillariaFritillaria thunbergii
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0868 Chuan Du Huo川独活 Doubleteeth pubescent angelicaAngelica pubescens
H0855 Chuan Bei Mu川贝母 Fritillaria unibracteataFritillaria cirrhosa
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H0974 Di Jin Cao地锦草 Humifuse euphorbiaEuphorbia humifusa
H0069 Jin Ying Zi Ti Qu Ye金樱子提取液 Cherokee rose seedRosa laevigata
H0472 Shu Da Huang熟大黄 NARheum palmatum
H1097 Gong Ding Xiang公丁香 NASyzygium aromaticum
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H0574 Cao Dou Kou草豆蔻 Katsumada galangalAlpinia katsumadai
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0060 Jin Si Ku Lian金丝苦楝 NACardiospermum halicacabum
H0070 Jing Da Ji京大戟 Peking euphorbia rootRadix euphorbiae pekinensis
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H1221 Hua Xiang Shu Guo Xu化香树果序 NAPlatycarya strobilacea
H0162 Long Dan龙胆 Rough gentianGentiana scabra
H1082 Gan Lan橄榄 CabbageCanarium album
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H1171 He Zi Rou诃子肉 Medicine terminaliaTerminalia chebula
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0635 Xian He Cao Jin Gao Fen仙鹤草浸膏粉 Japanese argimoniaAgrimonia pilosa var. japonica
H0067 Jin Ying Zi金樱子 Cherokee rose seedRosa laevigata
H0256 Ming Dang Shen明党参 Medicinal changiumChangium smyrnioides
H0152 Ling Zhi Jin Gao灵芝浸膏 NAGanoderma lucidum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H1170 He Zi诃子 Medicine terminaliaTerminalia chebula
H0656 Xiao Bo Gen小檗根 Barberry rootBerberis julianae
H0237 Mei Gui Hua玫瑰花 Rugose rose flowerRosa rugosa
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H1137 Gui Yuan桂圆 NADimocarpus longan
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0343 Qing Hao Zi青蒿子 sweet wormwoodArtemisia carvifolia
H0995 Dong Chong Xia Cao冬虫夏草 AwetoCordyceps sinensis
H0735 Yi Bei Mu伊贝母 Siberian fritillary equivalent plant: fritillaria walujewiiFritillaria pallidiflora
H0759 Yu Gan Zi余甘子 Emblic leafflower fruitFructus phyllanthi
H0959 Dang Shen Lu Tou党参芦头 Rhizome of pilose asiabellRhizoma codonopsis pilosulae
H0370 Ru Xiang乳香 OlibanumBoswellia carterii
H0990 Ding Xiang丁香 Clove treeSyzygium aromaticum
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0934 Da Ji大戟 Peking spurge rootRadix euphorbiae pekinensis
H0859 Chuan Bei Mu Liu Jin Gao川贝母流浸膏 Fritillaria unibracteataFritillaria cirrhosa
H0869 Ba Dou巴豆 Pu rging crotonCroton tiglium
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0888 Ba Dou Ye巴豆叶 Pu rging crotonCroton tiglium
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0634 Xian He Cao仙鹤草 Japanese argimoniaAgrimonia pilosa var. japonica
H0252 Mian Da Ji绵大戟 NAEuphorbia pekinensis
H0128 Lao Guan Cao老鹳草 Wilford cranesbillGeranium wilfordii
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin
H0104 Bai Zhu白术 Largehead atractylodesAtractylodes macrocephala
H0342 Qing Hao青蒿 sweet wormwoodArtemisia carvifolia
H0772 Yue Ji Hua月季花 Chinese roseRosa chinensis
H1168 He Tao Ren核桃仁 English walnut seedSemen juglandis
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0068 Jin Ying Zi Rou金樱子肉 Cherokee rose seedRosa laevigata
H0163 Long Dan Jin Gao龙胆浸膏 Rough gentianGentiana scabra
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0975 Di Mian Cao地绵草 NAEuphorbia humifusa
H0153 Ling Zhi(1)灵芝 Lucid ganodermaGanoderma lucidum
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0582 Cao Dou Kou Ren草豆蔻仁 Katsumada galangalAlpinia katsumadai
H0843 Zi Bei Mu紫贝母 NAFritillaria unibracteata
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H1056 Fu Pen Zi覆盆子 Red-and-Yellow garden raspberryRubus idaeus
H1220 Hua Xiang Shu Guo化香树果 NAPlatycarya strobilacea
H0547 Cang Qing Guo藏青果 MyrobalanTerminalia chebula
H0416 Shan Shen山参 NAPanax ginseng
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin