HIT-result

Target Description

Type	Detail
Target ID	T45RI0
Protein Name	G protein-coupled receptor kinase 5
Uniprot ID	P34947
Protein Name Alias	EC 2.7.11.16; G protein-coupled receptor kinase GRK5
Gene ID	2869
Gene Symbol	GRK5
Gene Alias	GPRK5
TTD	T69612: Patented target
Pfam	PF00069 ; PF00615
GO	0046777:protein autophosphorylation 0047696:beta-adrenergic receptor kinase activity 0005829:cytosol 0004674:protein serine/threonine kinase activity 0008284:positive regulation of cell population proliferation 0006915:apoptotic process 0005543:phospholipid binding 0005524:ATP binding 0005886:plasma membrane 0016055:Wnt signaling pathway 0005080:protein kinase C binding 0031965:nuclear membrane 0007188:adenylate cyclase-modulating G protein-coupled receptor signaling pathway 0004703:G protein-coupled receptor kinase activity 0005737:cytoplasm 0007186:G protein-coupled receptor signaling pathway 0008277:regulation of G protein-coupled receptor signaling pathway 0007217:tachykinin receptor signaling pathway 0051726:regulation of cell cycle 0016607:nuclear speck 0043066:negative regulation of apoptotic process
PDB	4TND ; 4TNB ; 6PJX
Drugbank	NA
KEGG	hsa:2869

Type

Detail

Target ID

T45RI0

Protein Name

G protein-coupled receptor kinase 5

Uniprot ID

P34947

Protein Name Alias

EC 2.7.11.16; G protein-coupled receptor kinase GRK5

Gene ID

2869

Gene Symbol

GRK5

Gene Alias

GPRK5

TTD

T69612: Patented target

Pfam

PF00069 ; PF00615

0046777:protein autophosphorylation

0047696:beta-adrenergic receptor kinase activity

0005829:cytosol

0004674:protein serine/threonine kinase activity

0008284:positive regulation of cell population proliferation

0006915:apoptotic process

0005543:phospholipid binding

0005524:ATP binding

0005886:plasma membrane

0016055:Wnt signaling pathway

0005080:protein kinase C binding

0031965:nuclear membrane

0007188:adenylate cyclase-modulating G protein-coupled receptor signaling pathway

0004703:G protein-coupled receptor kinase activity

0005737:cytoplasm

0007186:G protein-coupled receptor signaling pathway

0008277:regulation of G protein-coupled receptor signaling pathway

0007217:tachykinin receptor signaling pathway

0051726:regulation of cell cycle

0016607:nuclear speck

0043066:negative regulation of apoptotic process

PDB

4TND ; 4TNB ; 6PJX

Drugbank

KEGG

hsa:2869

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0888	Ba Dou Ye	巴豆叶	Pu rging croton	Croton tiglium
H0582	Cao Dou Kou Ren	草豆蔻仁	Katsumada galangal	Alpinia katsumadai
H0869	Ba Dou	巴豆	Pu rging croton	Croton tiglium
H1167	He Tao	核桃	English walnut seed	Semen juglandis
H0574	Cao Dou Kou	草豆蔻	Katsumada galangal	Alpinia katsumadai
H1168	He Tao Ren	核桃仁	English walnut seed	Semen juglandis
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0878	Ba Dou Shuang	巴豆霜	Defatted croton seed powder	Croton tiglium

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 9)