Target Description

Type Detail
Target ID T79A7K
Protein Name Protein PML
Uniprot ID P29590
Protein Name Alias Promyelocytic leukemia protein;  RING finger protein 71;  Tripartite motif-containing protein 19
Gene ID 5371
Gene Symbol PML
Gene Alias MYL;  PP8675;  RNF71;  TRIM19
TTD T01683: Research target
Pfam PF00643 ; PF12126
GO
0016605:PML body

0050897:cobalt ion binding

0008630:intrinsic apoptotic signaling pathway in response to DNA damage

0001932:regulation of protein phosphorylation

0034097:response to cytokine

0060444:branching involved in mammary gland duct morphogenesis

0043161:proteasome-mediated ubiquitin-dependent protein catabolic process

0032469:endoplasmic reticulum calcium ion homeostasis

0042803:protein homodimerization activity

0007050:cell cycle arrest

0006915:apoptotic process

0032691:negative regulation of interleukin-1 beta production

0045087:innate immune response

0005737:cytoplasm

0090398:cellular senescence

0019058:viral life cycle

0042771:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

0060333:interferon-gamma-mediated signaling pathway

0005829:cytosol

2000059:negative regulation of ubiquitin-dependent protein catabolic process

0042752:regulation of circadian rhythm

0032922:circadian regulation of gene expression

0046982:protein heterodimerization activity

0065003:protein-containing complex assembly

0005654:nucleoplasm

0030578:PML body organization

1990830:cellular response to leukemia inhibitory factor

2001238:positive regulation of extrinsic apoptotic signaling pathway

0031965:nuclear membrane

0030851:granulocyte differentiation

0001666:response to hypoxia

0008285:negative regulation of cell population proliferation

0032183:SUMO binding

0002230:positive regulation of defense response to virus by host

0032206:positive regulation of telomere maintenance

0048384:retinoic acid receptor signaling pathway

0048146:positive regulation of fibroblast proliferation

0031065:positive regulation of histone deacetylation

0003677:DNA binding

0007179:transforming growth factor beta receptor signaling pathway

0006355:regulation of transcription, DNA-templated

0045165:cell fate commitment

0050821:protein stabilization

0007182:common-partner SMAD protein phosphorylation

0010761:fibroblast migration

0031901:early endosome membrane

0000785:chromatin

0051974:negative regulation of telomerase activity

0032938:negative regulation of translation in response to oxidative stress

0032211:negative regulation of telomere maintenance via telomerase

0031625:ubiquitin protein ligase binding

0045892:negative regulation of transcription, DNA-templated

0140037:sumo-dependent protein binding

0042802:identical protein binding

2000779:regulation of double-strand break repair

0009411:response to UV

0071353:cellular response to interleukin-4

0097191:extrinsic apoptotic signaling pathway

0046332:SMAD binding

0005730:nucleolus

0042406:extrinsic component of endoplasmic reticulum membrane

0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

0030308:negative regulation of cell growth

1901796:regulation of signal transduction by p53 class mediator

0010522:regulation of calcium ion transport into cytosol

0004842:ubiquitin-protein transferase activity

0005634:nucleus

0030155:regulation of cell adhesion

0000792:heterochromatin

0016525:negative regulation of angiogenesis

1904816:positive regulation of protein localization to chromosome, telomeric region

0006605:protein targeting

0016363:nuclear matrix

0008270:zinc ion binding

0006606:protein import into nucleus

0051607:defense response to virus

0051457:maintenance of protein location in nucleus

0045893:positive regulation of transcription, DNA-templated

0008631:intrinsic apoptotic signaling pathway in response to oxidative stress

0060058:positive regulation of apoptotic process involved in mammary gland involution

0003713:transcription coactivator activity

0043153:entrainment of circadian clock by photoperiod

0045930:negative regulation of mitotic cell cycle

1902187:negative regulation of viral release from host cell

0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process

0010332:response to gamma radiation

0006977:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

0000781:chromosome, telomeric region

PDB 4WJO ; 2MVW ; 6UYS ; 6UYR ; 6UYU ; 6UYT ; 6UYV ; 1BOR ; 5YUF ; 6IMQ ; 6UYQ ; 2MWX ; 6UYP ; 4WJN ; 6UYO
Drugbank DB01169
KEGG hsa:5371

Related Compounds  (Total: 1)

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C0101
Name: Genistein


Related Herbs  (Total: 45)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H1227 Huai Zhi槐枝 NASophora japonica
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1007 Dou You豆油 Soybean oilGlycine max
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0995 Dong Chong Xia Cao冬虫夏草 AwetoCordyceps sinensis
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0852 Zi Tan紫檀 Burmacoast padaukPterocarpus indicus
H0026 Jiang Soybean pasteGlycine max
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0979 Di Yu地榆 Garden burnetSanguisorba officinalis
H0906 Ci Wan刺苋 spiny amaranthAmaranthus spinosus
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0792 Zhang Yu章鱼 Common atlantic octopusOctopus vulgaris
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0129 Le Xian Cai勒苋菜 NAAmaranthus spinosus
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1225 Huai Mi槐米 NASophora japonica
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0980 Di Yu Tan地榆炭 Garden burnetSanguisorba officinalis
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis