HIT-result

Target Description

Type	Detail
Target ID	T79A7K
Protein Name	Protein PML
Uniprot ID	P29590
Protein Name Alias	Promyelocytic leukemia protein; RING finger protein 71; Tripartite motif-containing protein 19
Gene ID	5371
Gene Symbol	PML
Gene Alias	MYL; PP8675; RNF71; TRIM19
TTD	T01683: Research target
Pfam	PF00643 ; PF12126
GO	0016605:PML body 0050897:cobalt ion binding 0008630:intrinsic apoptotic signaling pathway in response to DNA damage 0001932:regulation of protein phosphorylation 0034097:response to cytokine 0060444:branching involved in mammary gland duct morphogenesis 0043161:proteasome-mediated ubiquitin-dependent protein catabolic process 0032469:endoplasmic reticulum calcium ion homeostasis 0042803:protein homodimerization activity 0007050:cell cycle arrest 0006915:apoptotic process 0032691:negative regulation of interleukin-1 beta production 0045087:innate immune response 0005737:cytoplasm 0090398:cellular senescence 0019058:viral life cycle 0042771:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 0060333:interferon-gamma-mediated signaling pathway 0005829:cytosol 2000059:negative regulation of ubiquitin-dependent protein catabolic process 0042752:regulation of circadian rhythm 0032922:circadian regulation of gene expression 0046982:protein heterodimerization activity 0065003:protein-containing complex assembly 0005654:nucleoplasm 0030578:PML body organization 1990830:cellular response to leukemia inhibitory factor 2001238:positive regulation of extrinsic apoptotic signaling pathway 0031965:nuclear membrane 0030851:granulocyte differentiation 0001666:response to hypoxia 0008285:negative regulation of cell population proliferation 0032183:SUMO binding 0002230:positive regulation of defense response to virus by host 0032206:positive regulation of telomere maintenance 0048384:retinoic acid receptor signaling pathway 0048146:positive regulation of fibroblast proliferation 0031065:positive regulation of histone deacetylation 0003677:DNA binding 0007179:transforming growth factor beta receptor signaling pathway 0006355:regulation of transcription, DNA-templated 0045165:cell fate commitment 0050821:protein stabilization 0007182:common-partner SMAD protein phosphorylation 0010761:fibroblast migration 0031901:early endosome membrane 0000785:chromatin 0051974:negative regulation of telomerase activity 0032938:negative regulation of translation in response to oxidative stress 0032211:negative regulation of telomere maintenance via telomerase 0031625:ubiquitin protein ligase binding 0045892:negative regulation of transcription, DNA-templated 0140037:sumo-dependent protein binding 0042802:identical protein binding 2000779:regulation of double-strand break repair 0009411:response to UV 0071353:cellular response to interleukin-4 0097191:extrinsic apoptotic signaling pathway 0046332:SMAD binding 0005730:nucleolus 0042406:extrinsic component of endoplasmic reticulum membrane 0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0030308:negative regulation of cell growth 1901796:regulation of signal transduction by p53 class mediator 0010522:regulation of calcium ion transport into cytosol 0004842:ubiquitin-protein transferase activity 0005634:nucleus 0030155:regulation of cell adhesion 0000792:heterochromatin 0016525:negative regulation of angiogenesis 1904816:positive regulation of protein localization to chromosome, telomeric region 0006605:protein targeting 0016363:nuclear matrix 0008270:zinc ion binding 0006606:protein import into nucleus 0051607:defense response to virus 0051457:maintenance of protein location in nucleus 0045893:positive regulation of transcription, DNA-templated 0008631:intrinsic apoptotic signaling pathway in response to oxidative stress 0060058:positive regulation of apoptotic process involved in mammary gland involution 0003713:transcription coactivator activity 0043153:entrainment of circadian clock by photoperiod 0045930:negative regulation of mitotic cell cycle 1902187:negative regulation of viral release from host cell 0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process 0010332:response to gamma radiation 0006977:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 0000781:chromosome, telomeric region
PDB	4WJO ; 2MVW ; 6UYS ; 6UYR ; 6UYU ; 6UYT ; 6UYV ; 1BOR ; 5YUF ; 6IMQ ; 6UYQ ; 2MWX ; 6UYP ; 4WJN ; 6UYO
Drugbank	DB01169
KEGG	hsa:5371

Type

Detail

Target ID

T79A7K

Protein Name

Protein PML

Uniprot ID

P29590

Protein Name Alias

Promyelocytic leukemia protein; RING finger protein 71; Tripartite motif-containing protein 19

Gene ID

5371

Gene Symbol

PML

Gene Alias

MYL; PP8675; RNF71; TRIM19

TTD

T01683: Research target

Pfam

PF00643 ; PF12126

0016605:PML body

0050897:cobalt ion binding

0008630:intrinsic apoptotic signaling pathway in response to DNA damage

0001932:regulation of protein phosphorylation

0034097:response to cytokine

0060444:branching involved in mammary gland duct morphogenesis

0043161:proteasome-mediated ubiquitin-dependent protein catabolic process

0032469:endoplasmic reticulum calcium ion homeostasis

0042803:protein homodimerization activity

0007050:cell cycle arrest

0006915:apoptotic process

0032691:negative regulation of interleukin-1 beta production

0045087:innate immune response

0005737:cytoplasm

0090398:cellular senescence

0019058:viral life cycle

0042771:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

0060333:interferon-gamma-mediated signaling pathway

0005829:cytosol

2000059:negative regulation of ubiquitin-dependent protein catabolic process

0042752:regulation of circadian rhythm

0032922:circadian regulation of gene expression

0046982:protein heterodimerization activity

0065003:protein-containing complex assembly

0005654:nucleoplasm

0030578:PML body organization

1990830:cellular response to leukemia inhibitory factor

2001238:positive regulation of extrinsic apoptotic signaling pathway

0031965:nuclear membrane

0030851:granulocyte differentiation

0001666:response to hypoxia

0008285:negative regulation of cell population proliferation

0032183:SUMO binding

0002230:positive regulation of defense response to virus by host

0032206:positive regulation of telomere maintenance

0048384:retinoic acid receptor signaling pathway

0048146:positive regulation of fibroblast proliferation

0031065:positive regulation of histone deacetylation

0003677:DNA binding

0007179:transforming growth factor beta receptor signaling pathway

0006355:regulation of transcription, DNA-templated

0045165:cell fate commitment

0050821:protein stabilization

0007182:common-partner SMAD protein phosphorylation

0010761:fibroblast migration

0031901:early endosome membrane

0000785:chromatin

0051974:negative regulation of telomerase activity

0032938:negative regulation of translation in response to oxidative stress

0032211:negative regulation of telomere maintenance via telomerase

0031625:ubiquitin protein ligase binding

0045892:negative regulation of transcription, DNA-templated

0140037:sumo-dependent protein binding

0042802:identical protein binding

2000779:regulation of double-strand break repair

0009411:response to UV

0071353:cellular response to interleukin-4

0097191:extrinsic apoptotic signaling pathway

0046332:SMAD binding

0005730:nucleolus

0042406:extrinsic component of endoplasmic reticulum membrane

0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

0030308:negative regulation of cell growth

1901796:regulation of signal transduction by p53 class mediator

0010522:regulation of calcium ion transport into cytosol

0004842:ubiquitin-protein transferase activity

0005634:nucleus

0030155:regulation of cell adhesion

0000792:heterochromatin

0016525:negative regulation of angiogenesis

1904816:positive regulation of protein localization to chromosome, telomeric region

0006605:protein targeting

0016363:nuclear matrix

0008270:zinc ion binding

0006606:protein import into nucleus

0051607:defense response to virus

0051457:maintenance of protein location in nucleus

0045893:positive regulation of transcription, DNA-templated

0008631:intrinsic apoptotic signaling pathway in response to oxidative stress

0060058:positive regulation of apoptotic process involved in mammary gland involution

0003713:transcription coactivator activity

0043153:entrainment of circadian clock by photoperiod

0045930:negative regulation of mitotic cell cycle

1902187:negative regulation of viral release from host cell

0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process

0010332:response to gamma radiation

0006977:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

0000781:chromosome, telomeric region

PDB

4WJO ; 2MVW ; 6UYS ; 6UYR ; 6UYU ; 6UYT ; 6UYV ; 1BOR ; 5YUF ; 6IMQ ; 6UYQ ; 2MWX ; 6UYP ; 4WJN ; 6UYO

Drugbank

DB01169

KEGG

hsa:5371

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0111	Ku Shen	苦参	Lightyellow sophora	Sophora flavescens
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1080	Gan Ge	干葛	Lobed kudzuvine root	Pueraria lobata
H0852	Zi Tan	紫檀	Burmacoast padauk	Pterocarpus indicus
H0995	Dong Chong Xia Cao	冬虫夏草	Aweto	Cordyceps sinensis
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H0980	Di Yu Tan	地榆炭	Garden burnet	Sanguisorba officinalis
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1124	Guang Jin Qian Cao	广金钱草	Snowbellleaf tickclover	Desmodium styracifolium
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0026	Jiang	姜	Soybean paste	Glycine max
H1095	Ge Gen Gan Jin Gao	葛根干浸膏	Lobed kudzuvine root	Pueraria lobata
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0575	Tu Ku Shen	土苦参	all-grass of hooker winghead	Sophora flavescens
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H0129	Le Xian Cai	勒苋菜	NA	Amaranthus spinosus
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0979	Di Yu	地榆	Garden burnet	Sanguisorba officinalis
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0792	Zhang Yu	章鱼	Common atlantic octopus	Octopus vulgaris
H1094	Ge Gen	葛根	Lobed kudzuvine root	Pueraria lobata
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0906	Ci Wan	刺苋	spiny amaranth	Amaranthus spinosus
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1096	Ge Hua	葛花	flower bud of lobed kudzuvine	Pueraria lobata
H0533	Teng Ku Shen	藤苦参	NA	Sophora flavescens
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1225	Huai Mi	槐米	NA	Sophora japonica
H1007	Dou You	豆油	Soybean oil	Glycine max
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 45)