Target Description

Type Detail
Target ID T68NCI
Protein Name Aldo-keto reductase family 1 member B1
Uniprot ID P15121
Protein Name Alias EC 1.1.1.300;  EC 1.1.1.372;  EC 1.1.1.54;  Aldehyde reductase;  Aldose reductase;  AR;  EC 1.1.1.21
Gene ID 231
Gene Symbol AKR1B1
Gene Alias ALDR1;  ALR2
TTD T26623: Successful target
Pfam PF00248
GO
1901653:cellular response to peptide

0006061:sorbitol biosynthetic process

0005829:cytosol

0072205:metanephric collecting duct development

0047834:D-threo-aldose 1-dehydrogenase activity

0036130:prostaglandin H2 endoperoxidase reductase activity

0009414:response to water deprivation

0046427:positive regulation of receptor signaling pathway via JAK-STAT

0048661:positive regulation of smooth muscle cell proliferation

0047655:allyl-alcohol dehydrogenase activity

0072061:inner medullary collecting duct development

0005975:carbohydrate metabolic process

0060135:maternal process involved in female pregnancy

0097066:response to thyroid hormone

0042629:mast cell granule

0009055:electron transfer activity

0071475:cellular hyperosmotic salinity response

0044598:doxorubicin metabolic process

0043066:negative regulation of apoptotic process

0006700:C21-steroid hormone biosynthetic process

0005615:extracellular space

0005654:nucleoplasm

0001523:retinoid metabolic process

0018931:naphthalene metabolic process

0033010:paranodal junction

0097454:Schwann cell microvillus

0070062:extracellular exosome

0001894:tissue homeostasis

0047956:glycerol dehydrogenase [NADP+] activity

0044597:daunorubicin metabolic process

0043220:Schmidt-Lanterman incisure

0035809:regulation of urine volume

0046370:fructose biosynthetic process

0032838:plasma membrane bounded cell projection cytoplasm

0031098:stress-activated protein kinase signaling cascade

0097238:cellular response to methylglyoxal

0002070:epithelial cell maturation

0042415:norepinephrine metabolic process

0003091:renal water homeostasis

0001758:retinal dehydrogenase activity

0004032:alditol:NADP+ 1-oxidoreductase activity

0052650:NADP-retinol dehydrogenase activity

0043795:glyceraldehyde oxidoreductase activity

0048471:perinuclear region of cytoplasm

PDB 3M64 ; 2ACR ; 2IKH ; 2PDH ; 2HVN ; 4XZH ; 5OUJ ; 2PEV ; 3GHU ; 4LB3 ; 3LQG ; 2FZD ; 3V35 ; 2IKJ ; 3U2C ; 4IGS ; 3LQL ; 2AGT ; 2PFH ; 4JIR ; 2FZ9 ; 3P2V ; 5OUK ; 3LEP ; 2PDJ ; 3MC5 ; 6T7Q ; 2HVO ; 3GHS ; 1T40 ; 4PRT ; 2PDM ; 4RPQ ; 2PDQ ; 3LBO ; 3LEN ; 2J8T ; 1EL3 ; 2PDB ; 1ABN ; 2PDK ; 2DUX ; 3GHR ; 2PDY ; 1X96 ; 3S3G ; 1AZ1 ; 4QX4 ; 2PDU ; 6F7R ; 2INZ ; 2IQ0 ; 6F8O ; 4GQ0 ; 3G5E ; 1XGD ; 2PD5 ; 1IEI ; 4QR6 ; 5HA7 ; 2F2K ; 2PDI ; 3GHT ; 6F81 ; 2PDF ; 4LB4 ; 6TD8 ; 3M4H ; 1X98 ; 2QXW ; 4YU1 ; 2DUZ ; 2IPW ; 3V36 ; 2PDN ; 1PWL ; 2DV0 ; 2IQD ; 6T5G ; 2IKG ; 2PDP ; 2PDC ; 3MB9 ; 6T3P ; 3ONB ; 2IS7 ; 4PRR ; 3T42 ; 2PD9 ; 3M0I ; 4LBS ; 3LZ5 ; 3Q65 ; 2FZB ; 4LAZ ; 4PUU ; 1Z8A ; 1Z3N ; 2PF8 ; 2PDX ; 4NKC ; 1ADS ; 2NVD ; 1T41 ; 1AZ2 ; 1PWM ; 4YS1 ; 2ACS ; 4Q7B ; 2PZN ; 3ONC ; 2PDL ; 2ACQ ; 4PR4 ; 6SYW ; 2I17 ; 3LD5 ; 1Z89 ; 4LBR ; 4QBX ; 2HV5 ; 4GCA ; 4PUW ; 6F82 ; 1EF3 ; 3LZ3 ; 3RX3 ; 5OU0 ; 4LAU ; 2R24 ; 6T27 ; 2I16 ; 2FZ8 ; 2ACU ; 6F84 ; 2IKI ; 3Q67 ; 4XZI ; 4QXI ; 1MAR ; 3RX2 ; 1X97 ; 1US0 ; 3RX4 ; 2ISF ; 2NVC ; 3DN5 ; 2PDG ; 2PDW ; 3BCJ ; 2INE
Drugbank DB08000 ; DB02101 ; DB08084 ; DB07999 ; DB01689 ; DB02020 ; DB02007 ; DB00143 ; DB07063 ; DB02712 ; DB02834 ; DB07187 ; DB02518 ; DB08772 ; DB05533 ; DB03461 ; DB07498 ; DB06077 ; DB08098 ; DB07093 ; DB11859 ; DB02994 ; DB07028 ; DB02132 ; DB02021 ; DB06246 ; DB04272 ; DB00157 ; DB02383 ; DB07139 ; DB07450 ; DB08449 ; DB01039 ; DB05327 ; DB07030 ; DB00605 ; DB05383
KEGG hsa:231

Related Compounds  (Total: 13)

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C0055
Name: Estradiol
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C0097
Name: Ganoderic Acid F
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C0101
Name: Genistein
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C0106
Name: Glutathione
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C0316
Name: Piplartine


Related Herbs  (Total: 82)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0437 She Xiang麝香 AbelmuskMoschus moschiferus
H1227 Huai Zhi槐枝 NASophora japonica
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0152 Ling Zhi Jin Gao灵芝浸膏 NAGanoderma lucidum
H0077 Jiu EthanolVinum
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H0153 Ling Zhi(1)灵芝 Lucid ganodermaGanoderma lucidum
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H1064 Ge Jie蛤蚧 Tokay geckoGecko
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H0961 Dang Yao当药 Chinese swertiaSwertia chinensis
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1007 Dou You豆油 Soybean oilGlycine max
H0520 Tai Pan Fen胎盘粉 Fetus powderHuman placenta
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0356 Ren Gong She Xiang人工麝香 AbelmuskMoschus moschiferus
H1163 He Bao Cao荷包草 NALamprocapnos spectabilis
H1102 Gu Sui Bu骨碎补 Fortune’s drynaria rhizomeDrynaria fortunei
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H1176 Hei Hu Jiao黑胡椒 Black pepperPiper nigrum
H0792 Zhang Yu章鱼 Common atlantic octopusOctopus vulgaris
H0979 Di Yu地榆 Garden burnetSanguisorba officinalis
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H0129 Le Xian Cai勒苋菜 NAAmaranthus spinosus
H0471 Shou Shen手参 Fragrant orchidGymnadenia conopsea
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0026 Jiang Soybean pasteGlycine max
H0236 Mao She Xiang Jin Gao毛麝香浸膏 AbelmuskMoschus moschiferus
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H1214 Hua Jiao花椒 Bunge pricklyashZanthoxylum bungeanum
H0995 Dong Chong Xia Cao冬虫夏草 AwetoCordyceps sinensis
H1245 Bai Qian白前 Cynanchum rootCynanchum stauntonii
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0295 Bi Ba荜茇 Long pepperPiper longum
H0852 Zi Tan紫檀 Burmacoast padaukPterocarpus indicus
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0162 Long Dan龙胆 Rough gentianGentiana scabra
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0980 Di Yu Tan地榆炭 Garden burnetSanguisorba officinalis
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H1204 Hu Jiao胡椒 Black pepperPiper nigrum
H0006 Bai Qu Cai白屈菜 Greater celandineChelidonium majus
H1225 Huai Mi槐米 NASophora japonica
H0235 Mao She Xiang毛麝香 AbelmuskMoschus moschiferus
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1077 Bai Hu Jiao白胡椒 white pepperPiper nigrum
H0233 Mao Liang Mian Zhen毛两面针 NAZanthoxylum nitidum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0521 Tai Pan Zu Zhi Fen胎盘组织粉 NAHuman placenta
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0661 Xiao Hei Dou小黑豆 Black turtle beanPhaseolus vulgaris
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H0906 Ci Wan刺苋 spiny amaranthAmaranthus spinosus
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis