HIT-result

Type	Detail
Target ID	T04A2Q
Protein Name	Serine/threonine-protein kinase PLK1
Uniprot ID	P53350
Protein Name Alias	EC 2.7.11.21; Polo-like kinase 1; PLK-1; Serine/threonine-protein kinase 13; STPK13
Gene ID	5347
Gene Symbol	PLK1
Gene Alias	PLK
TTD	T40694: Clinical Trial target
Pfam	PF00069 ; PF00659
GO	0045184:establishment of protein localization 0010389:regulation of G2/M transition of mitotic cell cycle 0004674:protein serine/threonine kinase activity 0030071:regulation of mitotic metaphase/anaphase transition 0032465:regulation of cytokinesis 0005524:ATP binding 0005819:spindle 0051233:spindle midzone 0043066:negative regulation of apoptotic process 0006468:protein phosphorylation 0045143:homologous chromosome segregation 0030496:midbody 0000795:synaptonemal complex 0007346:regulation of mitotic cell cycle 1904776:regulation of protein localization to cell cortex 0097431:mitotic spindle pole 0106311:protein threonine kinase activity 0070194:synaptonemal complex disassembly 0007077:mitotic nuclear envelope disassembly 0007098:centrosome cycle 0000942:condensed nuclear chromosome outer kinetochore 0007076:mitotic chromosome condensation 0018105:peptidyl-serine phosphorylation 1902749:regulation of cell cycle G2/M phase transition 0090435:protein localization to nuclear envelope 0007062:sister chromatid cohesion 0005829:cytosol 1904668:positive regulation of ubiquitin protein ligase activity 0034451:centriolar satellite 0032436:positive regulation of proteasomal ubiquitin-dependent protein catabolic process 0042802:identical protein binding 0010997:anaphase-promoting complex binding 0010800:positive regulation of peptidyl-threonine phosphorylation 0051443:positive regulation of ubiquitin-protein transferase activity 0031145:anaphase-promoting complex-dependent catabolic process 0000281:mitotic cytokinesis 0001578:microtubule bundle formation 0000287:magnesium ion binding 0051081:nuclear envelope disassembly 0005654:nucleoplasm 0000278:mitotic cell cycle 0097711:ciliary basal body-plasma membrane docking 0071168:protein localization to chromatin 0000922:spindle pole 0005737:cytoplasm 1901673:regulation of mitotic spindle assembly 0006511:ubiquitin-dependent protein catabolic process 0015630:microtubule cytoskeleton 0072425:signal transduction involved in G2 DNA damage checkpoint 0016321:female meiosis chromosome segregation 0051726:regulation of cell cycle 0000776:kinetochore 0007052:mitotic spindle organization 0004672:protein kinase activity 0000132:establishment of mitotic spindle orientation 0007094:mitotic spindle assembly checkpoint 0005814:centriole 0043393:regulation of protein binding 0005634:nucleus 0019901:protein kinase binding 0000086:G2/M transition of mitotic cell cycle 0045862:positive regulation of proteolysis 0000070:mitotic sister chromatid segregation 0045736:negative regulation of cyclin-dependent protein serine/threonine kinase activity 1900182:positive regulation of protein localization to nucleus 0016567:protein ubiquitination 0106310:protein serine kinase activity 0008017:microtubule binding 0000785:chromatin 0031648:protein destabilization 0000122:negative regulation of transcription by RNA polymerase II 1901990:regulation of mitotic cell cycle phase transition 0005813:centrosome
PDB	5NFU ; 4LKM ; 5J19 ; 5NN1 ; 4O6W ; 4O9W ; 4E9C ; 1Q4O ; 5NMM ; 4WHL ; 3RQ7 ; 2OGQ ; 4HAB ; 4WHK ; 4WHH ; 2OJX ; 5TA6 ; 3C5L ; 4DFW ; 2OWB ; 4HCO ; 2V5Q ; 5NEI ; 4X9V ; 3BZI ; 6GY2 ; 4A4O ; 3FVH ; 4H71 ; 5NJE ; 5TA8 ; 6AX4 ; 3Q1I ; 4HY2 ; 1Q4K ; 2OU7 ; 3FC2 ; 5NN2 ; 4H5X ; 4E67 ; 3HIK ; 1UMW ; 4A4L ; 4RCP ; 3THB ; 3P34 ; 4LKL ; 4O56 ; 4J52 ; 3P35 ; 4X9R ; 2YAC ; 3P37 ; 4E9D ; 3P36 ; 3KB7 ; 3HIH ; 3P2Z ; 2RKU ; 4X9W ; 4J53 ; 3P2W
Drugbank	DB07186 ; DB08059 ; DB06963 ; DB06897 ; DB12010 ; DB07789
KEGG	hsa:5347

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Name: Genistein

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Name: Lupeol

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Name: beta-hydroxyisovalerylshikonin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0296	Niu Teng	牛藤	twotooth achyranthes root	Achyranthes bidentata
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H0111	Ku Shen	苦参	Lightyellow sophora	Sophora flavescens
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0968	Di Feng Pi	地枫皮	Difengpi anisetree	Illicium difengpi
H1034	Fei Yang Cao	飞杨草	NA	Euphorbia hirta
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0152	Ling Zhi Jin Gao	灵芝浸膏	NA	Ganoderma lucidum
H1124	Guang Jin Qian Cao	广金钱草	Snowbellleaf tickclover	Desmodium styracifolium
H1133	Gui Jian Yu	鬼箭羽	Winged euonymus	Euonymus alatus
H1094	Ge Gen	葛根	Lobed kudzuvine root	Pueraria lobata
H1080	Gan Ge	干葛	Lobed kudzuvine root	Pueraria lobata
H0153	Ling Zhi(1)	灵芝	Lucid ganoderma	Ganoderma lucidum
H0711	Yuan Hua Zhi Tiao	芫花枝条	stem of lilac daphne	Daphne genkwa
H0315	Pu Gong Ying Jin Gao	蒲公英浸膏	Mongolian dandelion	Taraxacum mongolicum
H0918	Cu Yuan Hua	醋芫花	Lilac daphne	Daphne genkwa
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H0975	Di Mian Cao	地绵草	NA	Euphorbia humifusa
H0214	Bei He Huan	北合欢	Albizia	Albizia julibrissin
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H1184	Bai Lian	白蔹	Japanese ampelopsis	Ampelopsis japonica
H0663	Xiao Ji	小蓟	Setose thistle	Cirsium setosum
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1007	Dou You	豆油	Soybean oil	Glycine max
H0297	Niu Xi	牛膝	Twotooth achyranthes	Achyranthes bidentata
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H0300	Nv Zhen Zi	女贞子	Glossy privet fruit	Ligustrum lucidum
H0314	Pu Gong Ying	蒲公英	Mongolian dandelion	Taraxacum mongolicum
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H1095	Ge Gen Gan Jin Gao	葛根干浸膏	Lobed kudzuvine root	Pueraria lobata
H0792	Zhang Yu	章鱼	Common atlantic octopus	Octopus vulgaris
H0979	Di Yu	地榆	Garden burnet	Sanguisorba officinalis
H0708	Yuan Hua Gen	芫花根	Lilac daphne root	Daphne genkwa
H0060	Jin Si Ku Lian	金丝苦楝	NA	Cardiospermum halicacabum
H0129	Le Xian Cai	勒苋菜	NA	Amaranthus spinosus
H0476	Can E	蚕蛾	Silkworm	Bombyx mori
H0318	Pu Tao(1)	蒲桃	Syzygium	Syzygium jambos
H0045	Jin Fei Cao	金沸草	Japanese inula	Inula japonica
H0120	Ban Bian Qi	半边旗	pinnated brake herb	Pteris semipinnata
H0327	Qian Li Guang	千里光	Climbing groundsel	Senecio scandens
H1244	Huang Miao	黄苗	NA	Taraxacum mongolicum
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0026	Jiang	姜	Soybean paste	Glycine max
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0533	Teng Ku Shen	藤苦参	NA	Sophora flavescens
H0974	Di Jin Cao	地锦草	Humifuse euphorbia	Euphorbia humifusa
H0995	Dong Chong Xia Cao	冬虫夏草	Aweto	Cordyceps sinensis
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H0855	Chuan Bei Mu	川贝母	Fritillaria unibracteata	Fritillaria cirrhosa
H0885	Chuan Xi Zhang Ya Cai	川西獐牙菜	Mussot swertia	Swertia mussotii
H0852	Zi Tan	紫檀	Burmacoast padauk	Pterocarpus indicus
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H0710	Yuan Hua Tiao	芫花条	stem of lilac daphne	Daphne genkwa
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0217	Man Jing Zi	蔓荆子	Threeleaf chastetree fruit	Vitex trifolia
H0463	Shi Liu Pi	石榴皮	Pomegranate peel	Punica granatum
H0738	Yi Xing Nan Wu Wei Zi	异型南五味子	Curious kadsura	Kadsura heteroclita
H0216	Man Jing Ye	蔓荆叶	Threeleaf chastetree leaf	Vitex trifolia
H0279	Nan Gua	南瓜	Cushaw	Cucurbita moschata
H0707	Yuan Hua	芫花	Lilac daphne	Daphne genkwa
H0980	Di Yu Tan	地榆炭	Garden burnet	Sanguisorba officinalis
H0689	Xue Feng Teng	血风藤	NA	Ventilago leiocarpa
H0575	Tu Ku Shen	土苦参	all-grass of hooker winghead	Sophora flavescens
H0859	Chuan Bei Mu Liu Jin Gao	川贝母流浸膏	Fritillaria unibracteata	Fritillaria cirrhosa
H1203	Hu Ji Sheng	槲寄生	Colored mistletoe	Viscum coloratum
H1225	Huai Mi	槐米	NA	Sophora japonica
H0289	Niu Bang Zi	牛蒡子	Great burdock fruit	Arctium lappa
H0515	Suan Shi Liu	酸石榴	Pomegranate	Punica granatum
H1096	Ge Hua	葛花	flower bud of lobed kudzuvine	Pueraria lobata
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H1179	Hei Mian Shen	黑面神	Leaf and twig of fruticose breynia	Breynia fruticosa
H0464	Shi Liu Zi	石榴子	NA	Punica granatum
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H0462	Shi Liu	石榴	Pomegranate fruit	Punica granatum
H0906	Ci Wan	刺苋	spiny amaranth	Amaranthus spinosus
H0762	Yu Li Ren	郁李仁	NA	Prunus japonica
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 98)