Compound Description
| ID: C0198 | Common name: Lupeol |
| IUPAC: (1R,3aR,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-ol | CAS: CAS:545-47-1 |
| Chembl ID: CHEMBL289191 | Pubchem ID: CID:259846 |
| Formula: C30H50O | TCM-ID: TCMC1515 |
| Smiles: CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C | |
| Alias:
Lup-20(29)-en-3β-ol;
Monogynol B; (3β)-Lup-20(29)-en-3-ol; 1H-Cyclopenta[a]chrysene, lup-20(29)-en-3-ol deriv.; (+)-Lupeol; 3β-Hydroxylup-20(29)-ene; Clerodol; Fagarasterol; Fagarsterol; Lupenol; Lupeol; NSC 90487; β-Viscol |
Structure:
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Related Targets (Total: 14)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
A | 1 Reference(s) |
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
A | 1 Reference(s) |
| T20JZ2 | Androgen receptor | AR |
P10275 |
A | 1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
A | 1 Reference(s) |
| T42K6K | M-phase inducer phosphatase 3 | CDC25C |
P30307 |
B | 1 Reference(s) |
| T04A2Q | Serine/threonine-protein kinase PLK1 | PLK1 |
P53350 |
B | 1 Reference(s) |
| T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
B | 1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
B | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
C | 1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
C | 1 Reference(s) |
| T69X4A | 14-3-3 protein sigma | SFN |
P31947 |
C | 1 Reference(s) |
| T37VLU | Interferon gamma | IFNG |
P01579 |
C | 1 Reference(s) |
| T58H37 | Perforin-1 | PRF1 |
P14222 |
C | 1 Reference(s) |
| T16CFE | Lysosome-associated membrane glycoprotein 1 | LAMP1 |
P11279 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 60)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H1203 | Hu Ji Sheng | 槲寄生 | Colored mistletoe | Viscum coloratum |
| H0016 | Ji Xue Cao | 积雪草 | Asiatic pennywort | Centella asiatica |
| H1184 | Bai Lian | 白蔹 | Japanese ampelopsis | Ampelopsis japonica |
| H0296 | Niu Teng | 牛藤 | twotooth achyranthes root | Achyranthes bidentata |
| H0663 | Xiao Ji | 小蓟 | Setose thistle | Cirsium setosum |
| H0289 | Niu Bang Zi | 牛蒡子 | Great burdock fruit | Arctium lappa |
| H0515 | Suan Shi Liu | 酸石榴 | Pomegranate | Punica granatum |
| H0111 | Ku Shen | 苦参 | Lightyellow sophora | Sophora flavescens |
| H0500 | Can Yong | 蚕蛹 | Silkworm chrysalis | Bombyx mori |
| H1134 | Bai Jiang Can | 白僵蚕 | Silkworm larva | Bombyx mori |
| H0951 | Dan Shen Jin Gao | 丹参浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0533 | Teng Ku Shen | 藤苦参 | NA | Sophora flavescens |
| H0297 | Niu Xi | 牛膝 | Twotooth achyranthes | Achyranthes bidentata |
| H0300 | Nv Zhen Zi | 女贞子 | Glossy privet fruit | Ligustrum lucidum |
| H0968 | Di Feng Pi | 地枫皮 | Difengpi anisetree | Illicium difengpi |
| H1034 | Fei Yang Cao | 飞杨草 | NA | Euphorbia hirta |
| H0490 | Can Jian | 蚕茧 | Silk cocoon | Bombyx mori |
| H0314 | Pu Gong Ying | 蒲公英 | Mongolian dandelion | Taraxacum mongolicum |
| H0974 | Di Jin Cao | 地锦草 | Humifuse euphorbia | Euphorbia humifusa |
| H0195 | Ma Chi Xian | 马齿苋 | Purslane | Portulaca oleracea |
| H0570 | Tu Fu Ling | 土茯苓 | Glabrous greenbrier | Smilax glabra |
| H0227 | Mang Guo Ye | 芒果叶 | Mango leaf | Mangifera indica |
| H0495 | Can Sha | 蚕砂 | Silkworm excrement | Bombyx mori |
| H0855 | Chuan Bei Mu | 川贝母 | Fritillaria unibracteata | Fritillaria cirrhosa |
| H1179 | Hei Mian Shen | 黑面神 | Leaf and twig of fruticose breynia | Breynia fruticosa |
| H0950 | Dan Shen Gan Jin Gao | 丹参干浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0885 | Chuan Xi Zhang Ya Cai | 川西獐牙菜 | Mussot swertia | Swertia mussotii |
| H0370 | Ru Xiang | 乳香 | Olibanum | Boswellia carterii |
| H0464 | Shi Liu Zi | 石榴子 | NA | Punica granatum |
| H1124 | Guang Jin Qian Cao | 广金钱草 | Snowbellleaf tickclover | Desmodium styracifolium |
| H1133 | Gui Jian Yu | 鬼箭羽 | Winged euonymus | Euonymus alatus |
| H0270 | Mu Hu Die | 木蝴蝶 | Indian trumpetflower | Oroxylum indicum |
| H0153 | Ling Zhi(1) | 灵芝 | Lucid ganoderma | Ganoderma lucidum |
| H0711 | Yuan Hua Zhi Tiao | 芫花枝条 | stem of lilac daphne | Daphne genkwa |
| H0949 | Dan Shen | 丹参 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0315 | Pu Gong Ying Jin Gao | 蒲公英浸膏 | Mongolian dandelion | Taraxacum mongolicum |
| H0918 | Cu Yuan Hua | 醋芫花 | Lilac daphne | Daphne genkwa |
| H0708 | Yuan Hua Gen | 芫花根 | Lilac daphne root | Daphne genkwa |
| H0060 | Jin Si Ku Lian | 金丝苦楝 | NA | Cardiospermum halicacabum |
| H0710 | Yuan Hua Tiao | 芫花条 | stem of lilac daphne | Daphne genkwa |
| H0975 | Di Mian Cao | 地绵草 | NA | Euphorbia humifusa |
| H0476 | Can E | 蚕蛾 | Silkworm | Bombyx mori |
| H0214 | Bei He Huan | 北合欢 | Albizia | Albizia julibrissin |
| H0217 | Man Jing Zi | 蔓荆子 | Threeleaf chastetree fruit | Vitex trifolia |
| H0463 | Shi Liu Pi | 石榴皮 | Pomegranate peel | Punica granatum |
| H0318 | Pu Tao(1) | 蒲桃 | Syzygium | Syzygium jambos |
| H0045 | Jin Fei Cao | 金沸草 | Japanese inula | Inula japonica |
| H0462 | Shi Liu | 石榴 | Pomegranate fruit | Punica granatum |
| H0738 | Yi Xing Nan Wu Wei Zi | 异型南五味子 | Curious kadsura | Kadsura heteroclita |
| H0216 | Man Jing Ye | 蔓荆叶 | Threeleaf chastetree leaf | Vitex trifolia |
| H0279 | Nan Gua | 南瓜 | Cushaw | Cucurbita moschata |
| H0707 | Yuan Hua | 芫花 | Lilac daphne | Daphne genkwa |
| H0120 | Ban Bian Qi | 半边旗 | pinnated brake herb | Pteris semipinnata |
| H0327 | Qian Li Guang | 千里光 | Climbing groundsel | Senecio scandens |
| H1244 | Huang Miao | 黄苗 | NA | Taraxacum mongolicum |
| H0762 | Yu Li Ren | 郁李仁 | NA | Prunus japonica |
| H0689 | Xue Feng Teng | 血风藤 | NA | Ventilago leiocarpa |
| H0575 | Tu Ku Shen | 土苦参 | all-grass of hooker winghead | Sophora flavescens |
| H0859 | Chuan Bei Mu Liu Jin Gao | 川贝母流浸膏 | Fritillaria unibracteata | Fritillaria cirrhosa |
| H0152 | Ling Zhi Jin Gao | 灵芝浸膏 | NA | Ganoderma lucidum |
Ckey description of the interaction between compound and target