Target Description
| Type | Detail |
|---|---|
| Target ID | T58H37 |
| Protein Name | Perforin-1 |
| Uniprot ID |
P14222 |
| Protein Name Alias | P1; Cytolysin; Lymphocyte pore-forming protein; PFP |
| Gene ID |
5551 |
| Gene Symbol | PRF1 |
| Gene Alias | PFP |
| TTD | NA |
| Pfam | PF00168 ; PF01823 |
| GO |
0042802:identical protein binding
0031904:endosome lumen 0051607:defense response to virus 0019835:cytolysis 0005829:cytosol 0006915:apoptotic process 0005509:calcium ion binding 0001913:T cell mediated cytotoxicity 0005886:plasma membrane 0022829:wide pore channel activity 0016021:integral component of membrane 0044194:cytolytic granule 0016020:membrane 0006968:cellular defense response 0051712:positive regulation of killing of cells of other organism 0005576:extracellular region 0002357:defense response to tumor cell 0002418:immune response to tumor cell 0001771:immunological synapse formation 0051260:protein homooligomerization |
| PDB | NA |
| Drugbank | NA |
| KEGG | hsa:5551 |
Related Herbs (Total: 60)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H1203 | Hu Ji Sheng | 槲寄生 | Colored mistletoe | Viscum coloratum |
| H0016 | Ji Xue Cao | 积雪草 | Asiatic pennywort | Centella asiatica |
| H1184 | Bai Lian | 白蔹 | Japanese ampelopsis | Ampelopsis japonica |
| H0296 | Niu Teng | 牛藤 | twotooth achyranthes root | Achyranthes bidentata |
| H0663 | Xiao Ji | 小蓟 | Setose thistle | Cirsium setosum |
| H0289 | Niu Bang Zi | 牛蒡子 | Great burdock fruit | Arctium lappa |
| H0515 | Suan Shi Liu | 酸石榴 | Pomegranate | Punica granatum |
| H0111 | Ku Shen | 苦参 | Lightyellow sophora | Sophora flavescens |
| H0500 | Can Yong | 蚕蛹 | Silkworm chrysalis | Bombyx mori |
| H1134 | Bai Jiang Can | 白僵蚕 | Silkworm larva | Bombyx mori |
| H0951 | Dan Shen Jin Gao | 丹参浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0533 | Teng Ku Shen | 藤苦参 | NA | Sophora flavescens |
| H0297 | Niu Xi | 牛膝 | Twotooth achyranthes | Achyranthes bidentata |
| H0300 | Nv Zhen Zi | 女贞子 | Glossy privet fruit | Ligustrum lucidum |
| H0968 | Di Feng Pi | 地枫皮 | Difengpi anisetree | Illicium difengpi |
| H1034 | Fei Yang Cao | 飞杨草 | NA | Euphorbia hirta |
| H0490 | Can Jian | 蚕茧 | Silk cocoon | Bombyx mori |
| H0314 | Pu Gong Ying | 蒲公英 | Mongolian dandelion | Taraxacum mongolicum |
| H0974 | Di Jin Cao | 地锦草 | Humifuse euphorbia | Euphorbia humifusa |
| H0195 | Ma Chi Xian | 马齿苋 | Purslane | Portulaca oleracea |
| H0570 | Tu Fu Ling | 土茯苓 | Glabrous greenbrier | Smilax glabra |
| H0227 | Mang Guo Ye | 芒果叶 | Mango leaf | Mangifera indica |
| H0495 | Can Sha | 蚕砂 | Silkworm excrement | Bombyx mori |
| H0855 | Chuan Bei Mu | 川贝母 | Fritillaria unibracteata | Fritillaria cirrhosa |
| H1179 | Hei Mian Shen | 黑面神 | Leaf and twig of fruticose breynia | Breynia fruticosa |
| H0950 | Dan Shen Gan Jin Gao | 丹参干浸膏 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0885 | Chuan Xi Zhang Ya Cai | 川西獐牙菜 | Mussot swertia | Swertia mussotii |
| H0370 | Ru Xiang | 乳香 | Olibanum | Boswellia carterii |
| H0464 | Shi Liu Zi | 石榴子 | NA | Punica granatum |
| H1124 | Guang Jin Qian Cao | 广金钱草 | Snowbellleaf tickclover | Desmodium styracifolium |
| H1133 | Gui Jian Yu | 鬼箭羽 | Winged euonymus | Euonymus alatus |
| H0270 | Mu Hu Die | 木蝴蝶 | Indian trumpetflower | Oroxylum indicum |
| H0153 | Ling Zhi(1) | 灵芝 | Lucid ganoderma | Ganoderma lucidum |
| H0711 | Yuan Hua Zhi Tiao | 芫花枝条 | stem of lilac daphne | Daphne genkwa |
| H0949 | Dan Shen | 丹参 | The root of red-rooted salvia | Salvia miltiorrhiza |
| H0315 | Pu Gong Ying Jin Gao | 蒲公英浸膏 | Mongolian dandelion | Taraxacum mongolicum |
| H0918 | Cu Yuan Hua | 醋芫花 | Lilac daphne | Daphne genkwa |
| H0708 | Yuan Hua Gen | 芫花根 | Lilac daphne root | Daphne genkwa |
| H0060 | Jin Si Ku Lian | 金丝苦楝 | NA | Cardiospermum halicacabum |
| H0710 | Yuan Hua Tiao | 芫花条 | stem of lilac daphne | Daphne genkwa |
| H0975 | Di Mian Cao | 地绵草 | NA | Euphorbia humifusa |
| H0476 | Can E | 蚕蛾 | Silkworm | Bombyx mori |
| H0214 | Bei He Huan | 北合欢 | Albizia | Albizia julibrissin |
| H0217 | Man Jing Zi | 蔓荆子 | Threeleaf chastetree fruit | Vitex trifolia |
| H0463 | Shi Liu Pi | 石榴皮 | Pomegranate peel | Punica granatum |
| H0318 | Pu Tao(1) | 蒲桃 | Syzygium | Syzygium jambos |
| H0045 | Jin Fei Cao | 金沸草 | Japanese inula | Inula japonica |
| H0462 | Shi Liu | 石榴 | Pomegranate fruit | Punica granatum |
| H0738 | Yi Xing Nan Wu Wei Zi | 异型南五味子 | Curious kadsura | Kadsura heteroclita |
| H0216 | Man Jing Ye | 蔓荆叶 | Threeleaf chastetree leaf | Vitex trifolia |
| H0279 | Nan Gua | 南瓜 | Cushaw | Cucurbita moschata |
| H0707 | Yuan Hua | 芫花 | Lilac daphne | Daphne genkwa |
| H0120 | Ban Bian Qi | 半边旗 | pinnated brake herb | Pteris semipinnata |
| H0327 | Qian Li Guang | 千里光 | Climbing groundsel | Senecio scandens |
| H1244 | Huang Miao | 黄苗 | NA | Taraxacum mongolicum |
| H0762 | Yu Li Ren | 郁李仁 | NA | Prunus japonica |
| H0689 | Xue Feng Teng | 血风藤 | NA | Ventilago leiocarpa |
| H0575 | Tu Ku Shen | 土苦参 | all-grass of hooker winghead | Sophora flavescens |
| H0859 | Chuan Bei Mu Liu Jin Gao | 川贝母流浸膏 | Fritillaria unibracteata | Fritillaria cirrhosa |
| H0152 | Ling Zhi Jin Gao | 灵芝浸膏 | NA | Ganoderma lucidum |