HIT-result

Type	Detail
Target ID	T70NYW
Protein Name	Fibroblast growth factor receptor 4
Uniprot ID	P22455
Protein Name Alias	FGFR-4; EC 2.7.10.1; CD antigen CD334
Gene ID	2264
Gene Symbol	FGFR4
Gene Alias	JTK2; TKF
TTD	T90989: Clinical Trial target
Pfam	PF07679 ; PF07714
GO	0030133:transport vesicle 0043235:receptor complex 0007275:multicellular organism development 0055062:phosphate ion homeostasis 0046777:protein autophosphorylation 0018108:peptidyl-tyrosine phosphorylation 0005007:fibroblast growth factor-activated receptor activity 0005783:endoplasmic reticulum 0007169:transmembrane receptor protein tyrosine kinase signaling pathway 0070857:regulation of bile acid biosynthetic process 0008284:positive regulation of cell population proliferation 0051897:positive regulation of protein kinase B signaling 0008543:fibroblast growth factor receptor signaling pathway 0000165:MAPK cascade 0005887:integral component of plasma membrane 0010628:positive regulation of gene expression 0017134:fibroblast growth factor binding 0008201:heparin binding 0005886:plasma membrane 0005524:ATP binding 0070374:positive regulation of ERK1 and ERK2 cascade 0042632:cholesterol homeostasis 2000573:positive regulation of DNA biosynthetic process 0045862:positive regulation of proteolysis 0005576:extracellular region 0005794:Golgi apparatus 0019216:regulation of lipid metabolic process 0004714:transmembrane receptor protein tyrosine kinase activity 0043085:positive regulation of catalytic activity 0042593:glucose homeostasis 0033674:positive regulation of kinase activity 0016477:cell migration 0010715:regulation of extracellular matrix disassembly 0005768:endosome
PDB	4QRC ; 6IUP ; 5XFJ ; 6JPJ ; 6YI8 ; 4XCU ; 4UXQ ; 4QQC ; 4TYG ; 6NVI ; 4QQ5 ; 5NUD ; 4TYJ ; 6IUO ; 6V9C ; 4TYI ; 6NVJ ; 6NVK ; 5XFF ; 4QQJ ; 1QCT ; 5JKG ; 4R6V ; 4TYE ; 6NVG ; 5NWZ ; 6J6Y ; 6JPE ; 6NVH ; 4QQT
Drugbank	DB08901 ; DB15102 ; DB12147 ; DB01109 ; DB09078
KEGG	hsa:2264

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H1225	Huai Mi	槐米	NA	Sophora japonica
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H0111	Ku Shen	苦参	Lightyellow sophora	Sophora flavescens
H0026	Jiang	姜	Soybean paste	Glycine max
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0533	Teng Ku Shen	藤苦参	NA	Sophora flavescens
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1007	Dou You	豆油	Soybean oil	Glycine max
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H1096	Ge Hua	葛花	flower bud of lobed kudzuvine	Pueraria lobata
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0995	Dong Chong Xia Cao	冬虫夏草	Aweto	Cordyceps sinensis
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H1124	Guang Jin Qian Cao	广金钱草	Snowbellleaf tickclover	Desmodium styracifolium
H0852	Zi Tan	紫檀	Burmacoast padauk	Pterocarpus indicus
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1094	Ge Gen	葛根	Lobed kudzuvine root	Pueraria lobata
H1080	Gan Ge	干葛	Lobed kudzuvine root	Pueraria lobata
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H1095	Ge Gen Gan Jin Gao	葛根干浸膏	Lobed kudzuvine root	Pueraria lobata
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H0792	Zhang Yu	章鱼	Common atlantic octopus	Octopus vulgaris
H0979	Di Yu	地榆	Garden burnet	Sanguisorba officinalis
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0129	Le Xian Cai	勒苋菜	NA	Amaranthus spinosus
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0906	Ci Wan	刺苋	spiny amaranth	Amaranthus spinosus
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H0980	Di Yu Tan	地榆炭	Garden burnet	Sanguisorba officinalis
H0575	Tu Ku Shen	土苦参	all-grass of hooker winghead	Sophora flavescens
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 45)