HIT-result

Type	Detail
Target ID	T53GFX
Protein Name	Arginase-1
Uniprot ID	P05089
Protein Name Alias	EC 3.5.3.1; Liver-type arginase; Type I arginase
Gene ID	383
Gene Symbol	ARG1
Gene Alias	NA
TTD	T29144: Clinical Trial target
Pfam	PF00491
GO	0042802:identical protein binding 0005634:nucleus 0007568:aging 0042832:defense response to protozoan 0019547:arginine catabolic process to ornithine 0006527:arginine catabolic process 0070301:cellular response to hydrogen peroxide 0010042:response to manganese ion 0005829:cytosol 0002250:adaptive immune response 0001938:positive regulation of endothelial cell proliferation 0043200:response to amino acid 0010269:response to selenium ion 0033189:response to vitamin A 0071222:cellular response to lipopolysaccharide 0046686:response to cadmium ion 0035578:azurophil granule lumen 0001889:liver development 0071560:cellular response to transforming growth factor beta stimulus 0032964:collagen biosynthetic process 0030324:lung development 0060056:mammary gland involution 0046007:negative regulation of activated T cell proliferation 0060336:negative regulation of interferon-gamma-mediated signaling pathway 0005737:cytoplasm 0005615:extracellular space 0043005:neuron projection 0014075:response to amine 0005741:mitochondrial outer membrane 0042493:response to drug 0000050:urea cycle 0043312:neutrophil degranulation 0030145:manganese ion binding 0009635:response to herbicide 0033197:response to vitamin E 0005576:extracellular region 0060135:maternal process involved in female pregnancy 2000552:negative regulation of T-helper 2 cell cytokine production 0042130:negative regulation of T cell proliferation 0048678:response to axon injury 0010043:response to zinc ion 0035580:specific granule lumen 0043025:neuronal cell body 0071377:cellular response to glucagon stimulus 0010963:regulation of L-arginine import 0071353:cellular response to interleukin-4 0071549:cellular response to dexamethasone stimulus 0051597:response to methylmercury 0004053:arginase activity 0045087:innate immune response 0070965:positive regulation of neutrophil mediated killing of fungus
PDB	4HWW ; 3TH7 ; 3LP7 ; 2ZAV ; 3E6K ; 3MFW ; 2PHO ; 3MJL ; 4HXQ ; 6V7C ; 6Q92 ; 6Q9P ; 2PLL ; 3F80 ; 1WVA ; 3SKK ; 3THH ; 4FCI ; 2AEB ; 4GWD ; 3LP4 ; 4IE1 ; 3TF3 ; 4GSM ; 4GWC ; 6V7D ; 3DJ8 ; 1WVB ; 3THE ; 2PHA ; 3E6V ; 6V7F ; 3KV2 ; 3GMZ ; 3SJT ; 3MFV ; 6QAF ; 4GSZ ; 4FCK ; 3THJ ; 4GSV ; 6V7E ; 3GN0
Drugbank	DB06757 ; DB02381 ; DB03731 ; DB04648 ; DB03904 ; DB01983 ; DB02689 ; DB02499 ; DB00129 ; DB04530 ; DB04197 ; DB03144 ; DB04585
KEGG	hsa:383

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1249	Huang Qi Jin Gao	黄芪浸膏	Membranous milkvetch	Astragalus membranaceus
H0405	Shan Dou Gen	山豆根	Tonkin sophora root	Sophora subprostrata
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0277	Nan Ban Lan Gen	南板蓝根	Indigowoad root	Baphicacanthus cusia
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1247	Huang Qi	黄芪	Membranous milkvetch	Astragalus membranaceus
H0278	Nan Ban Lan Gen Jin Gao Fen	南板蓝根浸膏粉	Indigowoad root	Baphicacanthus cusia
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0017	Ji Xue Teng	鸡血藤	Suberect spatholobus stem	Spatholobus suberectus
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1096	Ge Hua	葛花	flower bud of lobed kudzuvine	Pueraria lobata
H0108	Ku Lian Pi	苦楝皮	Chinaberry-tree bark	Melia azedarach
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H0995	Dong Chong Xia Cao	冬虫夏草	Aweto	Cordyceps sinensis
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max
H1080	Gan Ge	干葛	Lobed kudzuvine root	Pueraria lobata
H0019	Ji Xue Teng Gao	鸡血藤膏	Suberect spatholobus stem	Spatholobus suberectus
H1094	Ge Gen	葛根	Lobed kudzuvine root	Pueraria lobata
H0018	Ji Xue Teng Gan Gao	鸡血藤干膏	Suberect spatholobus stem	Spatholobus suberectus
H0705	Yan Hu Lu Ba	盐胡芦巴	Fenugreek	Trigonella foenum-graecum
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H0416	Shan Shen	山参	NA	Panax ginseng
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0194	Ma Bing Lang	马槟榔	Masaikai caper	Capparis masaikai
H1007	Dou You	豆油	Soybean oil	Glycine max
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H1021	E Da Xia	莪大夏	NA	Oxytropis falcata
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1250	Huang Qi Ti Qu Ye	黄芪提取液	Membranous milkvetch	Astragalus membranaceus
H1248	Huang Qi Gan Jin Gao	黄芪干浸膏	Membranous milkvetch	Astragalus membranaceus
H0981	Dian Ji Xue Teng Gao Fen	滇鸡血藤膏粉	Suberect spatholobus stem	Spatholobus suberectus
H0109	Ku Lian Zi	苦楝子	NA	Melia azedarach
H0897	Chuan Lian	川楝	Chinaberry	Melia azedarach
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0026	Jiang	姜	Soybean paste	Glycine max
H1152	Bai Jie Zi	白芥子	White mustard seed	Sinapis alba
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1095	Ge Gen Gan Jin Gao	葛根干浸膏	Lobed kudzuvine root	Pueraria lobata
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 48)