Compound Description
| ID: C1278 | Common name: Daidzein |
| IUPAC: 7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one | CAS: CAS:486-66-8 |
| Chembl ID: CHEMBL8145 | Pubchem ID: CID:5281708 |
| Formula: C15H10O4 | TCM-ID: TCMC983 |
| Smiles: C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)O)O | |
| Alias:
Daidzein;
Isoflavone, 4',7-dihydroxy-; 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4',7-Dihydroxyisoflavone; 7,4'-Dihydroxyisoflavone; Daidzeol; Daidzin aglycone; FW 635I-1; Isoaurostatin; K 251b; NPI 031E |
Structure:
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Related Targets (Total: 65)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T91W8B | All-trans-retinol dehydrogenase [NAD(+)] ADH4 | ADH4 |
P08319 |
A | 1 Reference(s) |
| T03VS9 | Protein-tyrosine kinase 2-beta | PTK2B |
Q14289 |
A | 1 Reference(s) |
| T44WZO | Alcohol dehydrogenase 1C | ADH1C |
P00326 |
A | 1 Reference(s) |
| T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
A | 1 Reference(s) |
| T50SX0 | Nuclear receptor subfamily 1 group I member 2 | NR1I2 |
O75469 |
A | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
A | 2 Reference(s) |
| T63YAO | Caveolin-1 | CAV1 |
Q03135 |
A | 2 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
A | 5 Reference(s) |
| T12PIB | Lysosomal alpha-glucosidase | GAA |
P10253 |
A | 1 Reference(s) |
| T32OC4 | Aldehyde dehydrogenase, mitochondrial | ALDH2 |
P05091 |
A | 1 Reference(s) |
| T54G8J | Protein kinase C delta type | PRKCD |
Q05655 |
A | 1 Reference(s) |
| T22MME | Quinone oxidoreductase | CRYZ |
Q08257 |
A | 1 Reference(s) |
| T04AHN | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 | HSD3B2 |
P26439 |
B | 1 Reference(s) |
| T84W8G | Aryl hydrocarbon receptor | AHR |
P35869 |
B | 1 Reference(s) |
| T23K1O | Calmodulin | CALM3;CALML2;CAM3;CAMC;CAMIII |
P62158 |
B | 1 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
B | 1 Reference(s) |
| T09TS5 | Gamma-aminobutyric acid type B receptor subunit 1 | GABBR1 |
Q9UBS5 |
B | 1 Reference(s) |
| T74ETU | Steroid 21-hydroxylase | CYP21A2 |
P08686 |
B | 1 Reference(s) |
| T50WUM | Leucine--tRNA ligase, cytoplasmic | LARS1 |
Q9P2J5 |
B | 1 Reference(s) |
| T05O6O | Estrogen receptor beta | ESR2 |
Q92731 |
B | 5 Reference(s) |
| T30V3R | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 | HSD3B1 |
P14060 |
B | 2 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
B | 2 Reference(s) |
| T67HAF | Signal transducer and activator of transcription 1-alpha/beta | STAT1 |
P42224 |
B | 1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
B | 1 Reference(s) |
| T29GH0 | Trefoil factor 1 | TFF1 |
P04155 |
B | 2 Reference(s) |
| T98JPP | Carnitine O-palmitoyltransferase 1, liver isoform | CPT1A |
P50416 |
B | 1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
B | 1 Reference(s) |
| T50V79 | Interleukin-4 | IL4 |
P05112 |
B | 1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
B | 2 Reference(s) |
| T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
B | 1 Reference(s) |
| T73S71 | Apolipoprotein B-100 | APOB |
P04114 |
B | 1 Reference(s) |
| T49PL1 | Low-density lipoprotein receptor | LDLR |
P01130 |
B | 1 Reference(s) |
| T07NZK | Low affinity immunoglobulin epsilon Fc receptor | FCER2 |
P06734 |
C | 1 Reference(s) |
| T11GHO | Transforming protein RhoA | RHOA |
P61586 |
C | 1 Reference(s) |
| T34AYH | Solute carrier family 52, riboflavin transporter, member 1 | SLC52A1 |
Q9NWF4 |
C | 1 Reference(s) |
| T36I66 | Metallothionein-2 | MT2A |
P02795 |
C | 1 Reference(s) |
| T90ZS8 | Endothelin-converting enzyme 1 | ECE1 |
P42892 |
C | 1 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
C | 1 Reference(s) |
| T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
C | 1 Reference(s) |
| T42XY2 | Insulin-like growth factor 1 receptor | IGF1R |
P08069 |
C | 1 Reference(s) |
| T16IWB | Growth arrest and DNA damage-inducible protein GADD45 alpha | GADD45A |
P24522 |
C | 1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
C | 1 Reference(s) |
| T29CYD | BRCA1-associated RING domain protein 1 | BARD1 |
Q99728 |
C | 1 Reference(s) |
| T41SFE | Histone acetyltransferase p300 | EP300 |
Q09472 |
C | 1 Reference(s) |
| T57R3V | Proliferation marker protein Ki-67 | MKI67 |
P46013 |
C | 1 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
C | 1 Reference(s) |
| T82I76 | Ubiquitin carboxyl-terminal hydrolase BAP1 | BAP1 |
Q92560 |
C | 1 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
C | 1 Reference(s) |
| T82S9G | DNA repair protein RAD51 homolog 1 | RAD51 |
Q06609 |
C | 1 Reference(s) |
| T53QOD | ATP synthase subunit beta, mitochondrial | ATP5F1B |
P06576 |
C | 1 Reference(s) |
| T63SUZ | NADH-ubiquinone oxidoreductase chain 6 | MT-ND6 |
P03923 |
C | 1 Reference(s) |
| T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
C | 1 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
C | 1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
C | 1 Reference(s) |
| T46HRF | Growth hormone receptor | GHR |
P10912 |
C | 1 Reference(s) |
| T35FQV | Microsomal triglyceride transfer protein large subunit | MTTP |
P55157 |
C | 1 Reference(s) |
| T16A2X | Catalase | CAT |
P04040 |
C | 1 Reference(s) |
| T70SFS | Superoxide dismutase [Mn], mitochondrial | SOD2 |
P04179 |
C | 1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
C | 1 Reference(s) |
| T28B0B | Monocarboxylate transporter 8 | SLC16A2 |
P36021 |
C | 1 Reference(s) |
| T53GFX | Arginase-1 | ARG1 |
P05089 |
C | 1 Reference(s) |
| T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
C | 1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
C | 1 Reference(s) |
| T35QZO | Cytochrome c | CYCS |
P99999 |
C | 1 Reference(s) |
| T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 44)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H1248 | Huang Qi Gan Jin Gao | 黄芪干浸膏 | Membranous milkvetch | Astragalus membranaceus |
| H1075 | Gan Cao Liu Jin Gao | 甘草流浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1073 | Gan Cao Jie | 甘草节 | Glycyrrhiza uralensis fisch | Glycyrrhiza uralensis |
| H0019 | Ji Xue Teng Gao | 鸡血藤膏 | Suberect spatholobus stem | Spatholobus suberectus |
| H0571 | Tu Gan Cao | 土甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0278 | Nan Ban Lan Gen Jin Gao Fen | 南板蓝根浸膏粉 | Indigowoad root | Baphicacanthus cusia |
| H0981 | Dian Ji Xue Teng Gao Fen | 滇鸡血藤膏粉 | Suberect spatholobus stem | Spatholobus suberectus |
| H0995 | Dong Chong Xia Cao | 冬虫夏草 | Aweto | Cordyceps sinensis |
| H1080 | Gan Ge | 干葛 | Lobed kudzuvine root | Pueraria lobata |
| H1067 | Gan Cao Fen | 甘草粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0108 | Ku Lian Pi | 苦楝皮 | Chinaberry-tree bark | Melia azedarach |
| H1174 | Hei Da Dou | 黑大豆 | Black soyabean | Glycine max |
| H1070 | Gan Cao Gan Gao Fen | 甘草干膏粉 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0897 | Chuan Lian | 川楝 | Chinaberry | Melia azedarach |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H1152 | Bai Jie Zi | 白芥子 | White mustard seed | Sinapis alba |
| H0705 | Yan Hu Lu Ba | 盐胡芦巴 | Fenugreek | Trigonella foenum-graecum |
| H0952 | Dan Xiang Chi | 淡香豉 | NA | Glycine max |
| H1069 | Gan Cao Gan Gao | 甘草干膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1250 | Huang Qi Ti Qu Ye | 黄芪提取液 | Membranous milkvetch | Astragalus membranaceus |
| H1095 | Ge Gen Gan Jin Gao | 葛根干浸膏 | Lobed kudzuvine root | Pueraria lobata |
| H0240 | Mi Gan Cao | 蜜甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0084 | Jiu Li Xiang | 九里香 | Common jasminorange | Murraya paniculata |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H1074 | Gan Cao Jin Gao | 甘草浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0444 | Sheng Gan Cao | 生甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0026 | Jiang | 姜 | Soybean paste | Glycine max |
| H0405 | Shan Dou Gen | 山豆根 | Tonkin sophora root | Sophora subprostrata |
| H0027 | Jiang Gao | 姜膏 | Soybean paste | Glycine max |
| H1094 | Ge Gen | 葛根 | Lobed kudzuvine root | Pueraria lobata |
| H0017 | Ji Xue Teng | 鸡血藤 | Suberect spatholobus stem | Spatholobus suberectus |
| H0944 | Dan Dou Gu | 淡豆鼓 | NA | Glycine max |
| H0031 | Jiang Tan | 姜炭 | Soybean paste | Glycine max |
| H1249 | Huang Qi Jin Gao | 黄芪浸膏 | Membranous milkvetch | Astragalus membranaceus |
| H1066 | Gan Cao | 甘草 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1096 | Ge Hua | 葛花 | flower bud of lobed kudzuvine | Pueraria lobata |
| H0277 | Nan Ban Lan Gen | 南板蓝根 | Indigowoad root | Baphicacanthus cusia |
| H1071 | Gan Cao Gan Jin Gao | 甘草干浸膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H1021 | E Da Xia | 莪大夏 | NA | Oxytropis falcata |
| H1247 | Huang Qi | 黄芪 | Membranous milkvetch | Astragalus membranaceus |
| H1007 | Dou You | 豆油 | Soybean oil | Glycine max |
| H0109 | Ku Lian Zi | 苦楝子 | NA | Melia azedarach |
| H1072 | Gan Cao Gao | 甘草膏 | Glycyrrhiza inflata | Glycyrrhiza uralensis |
| H0018 | Ji Xue Teng Gan Gao | 鸡血藤干膏 | Suberect spatholobus stem | Spatholobus suberectus |
Ckey description of the interaction between compound and target