HIT-result

Type	Detail
Target ID	T16IWB
Protein Name	Growth arrest and DNA damage-inducible protein GADD45 alpha
Uniprot ID	P24522
Protein Name Alias	DNA damage-inducible transcript 1 protein; DDIT-1
Gene ID	1647
Gene Symbol	GADD45A
Gene Alias	DDIT1; GADD45
TTD	T23409: Research target
Pfam	PF01248
GO	2000379:positive regulation of reactive oxygen species metabolic process 0006977:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 0071901:negative regulation of protein serine/threonine kinase activity 0033140:negative regulation of peptidyl-serine phosphorylation of STAT protein 0071260:cellular response to mechanical stimulus 1900745:positive regulation of p38MAPK cascade 0007098:centrosome cycle 0007050:cell cycle arrest 0043065:positive regulation of apoptotic process 0046982:protein heterodimerization activity 0006915:apoptotic process 0005737:cytoplasm 0005654:nucleoplasm 1990841:promoter-specific chromatin binding 0046330:positive regulation of JNK cascade 0016525:negative regulation of angiogenesis 0019900:kinase binding 0000079:regulation of cyclin-dependent protein serine/threonine kinase activity 0051726:regulation of cell cycle 0071479:cellular response to ionizing radiation 0016607:nuclear speck 0042803:protein homodimerization activity 0005634:nucleus 0006281:DNA repair 0000122:negative regulation of transcription by RNA polymerase II 0000185:activation of MAPKKK activity 0071850:mitotic cell cycle arrest 0042770:signal transduction in response to DNA damage 0047485:protein N-terminus binding 0043537:negative regulation of blood vessel endothelial cell migration
PDB	2KG4
Drugbank	NA
KEGG	hsa:1647

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0416	Shan Shen	山参	NA	Panax ginseng
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H1250	Huang Qi Ti Qu Ye	黄芪提取液	Membranous milkvetch	Astragalus membranaceus
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0277	Nan Ban Lan Gen	南板蓝根	Indigowoad root	Baphicacanthus cusia
H0026	Jiang	姜	Soybean paste	Glycine max
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0022	Jia Ju	假蒟	Sarmentose pepper	Piper sarmentosum
H1007	Dou You	豆油	Soybean oil	Glycine max
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0108	Ku Lian Pi	苦楝皮	Chinaberry-tree bark	Melia azedarach
H1096	Ge Hua	葛花	flower bud of lobed kudzuvine	Pueraria lobata
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H1152	Bai Jie Zi	白芥子	White mustard seed	Sinapis alba
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H0018	Ji Xue Teng Gan Gao	鸡血藤干膏	Suberect spatholobus stem	Spatholobus suberectus
H0995	Dong Chong Xia Cao	冬虫夏草	Aweto	Cordyceps sinensis
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H1247	Huang Qi	黄芪	Membranous milkvetch	Astragalus membranaceus
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0019	Ji Xue Teng Gao	鸡血藤膏	Suberect spatholobus stem	Spatholobus suberectus
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H1080	Gan Ge	干葛	Lobed kudzuvine root	Pueraria lobata
H1094	Ge Gen	葛根	Lobed kudzuvine root	Pueraria lobata
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0278	Nan Ban Lan Gen Jin Gao Fen	南板蓝根浸膏粉	Indigowoad root	Baphicacanthus cusia
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H1095	Ge Gen Gan Jin Gao	葛根干浸膏	Lobed kudzuvine root	Pueraria lobata
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0109	Ku Lian Zi	苦楝子	NA	Melia azedarach
H0897	Chuan Lian	川楝	Chinaberry	Melia azedarach
H0981	Dian Ji Xue Teng Gao Fen	滇鸡血藤膏粉	Suberect spatholobus stem	Spatholobus suberectus
H0017	Ji Xue Teng	鸡血藤	Suberect spatholobus stem	Spatholobus suberectus
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H1021	E Da Xia	莪大夏	NA	Oxytropis falcata
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0511	Su Mu	苏木	Sappan caesalpinia	Caesalpinia sappan
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H1249	Huang Qi Jin Gao	黄芪浸膏	Membranous milkvetch	Astragalus membranaceus
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H0705	Yan Hu Lu Ba	盐胡芦巴	Fenugreek	Trigonella foenum-graecum
H0024	Jia 蒟ye	假蒟叶	Sarmentose pepper	Piper sarmentosum
H1248	Huang Qi Gan Jin Gao	黄芪干浸膏	Membranous milkvetch	Astragalus membranaceus
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max
H0405	Shan Dou Gen	山豆根	Tonkin sophora root	Sophora subprostrata

Target Description

Related Compounds (Total: 4)

Related Herbs (Total: 72)