HIT-result

Type	Detail
Target ID	T87FX7
Protein Name	Receptor-interacting serine/threonine-protein kinase 3
Uniprot ID	Q9Y572
Protein Name Alias	EC 2.7.11.1; RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3
Gene ID	11035
Gene Symbol	RIPK3
Gene Alias	RIP3
TTD	NA
Pfam	PF12721 ; PF00069
GO	0005524:ATP binding 0004672:protein kinase activity 0051092:positive regulation of NF-kappaB transcription factor activity 0106310:protein serine kinase activity 0002819:regulation of adaptive immune response 0043029:T cell homeostasis 0032649:regulation of interferon-gamma production 0044877:protein-containing complex binding 0097190:apoptotic signaling pathway 0006464:cellular protein modification process 2000452:regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation 0003713:transcription coactivator activity 0001914:regulation of T cell mediated cytotoxicity 0004704:NF-kappaB-inducing kinase activity 1990000:amyloid fibril formation 0097528:execution phase of necroptosis 0032147:activation of protein kinase activity 0004674:protein serine/threonine kinase activity 2001244:positive regulation of intrinsic apoptotic signaling pathway 0062099:negative regulation of programmed necrotic cell death 0051607:defense response to virus 0005829:cytosol 0005737:cytoplasm 0033077:T cell differentiation in thymus 0051353:positive regulation of oxidoreductase activity 0070301:cellular response to hydrogen peroxide 0032991:protein-containing complex 0097527:necroptotic signaling pathway 0010922:positive regulation of phosphatase activity 0106311:protein threonine kinase activity 0048538:thymus development 0060544:regulation of necroptotic process 0048536:spleen development 0007249:I-kappaB kinase/NF-kappaB signaling 0070266:necroptotic process 2000379:positive regulation of reactive oxygen species metabolic process 0046006:regulation of activated T cell proliferation 0042981:regulation of apoptotic process 0051351:positive regulation of ligase activity 0005634:nucleus 0042802:identical protein binding 0048535:lymph node development 0019054:modulation by virus of host cellular process 0060545:positive regulation of necroptotic process 0046777:protein autophosphorylation 0007165:signal transduction 0097300:programmed necrotic cell death 0070235:regulation of activation-induced cell death of T cells
PDB	5V7Z ; 5ZCK
Drugbank	NA
KEGG	hsa:11035

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Name: Matrine

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0111	Ku Shen	苦参	Lightyellow sophora	Sophora flavescens
H0405	Shan Dou Gen	山豆根	Tonkin sophora root	Sophora subprostrata