Compound Description
| ID: C0026 | Common name: Diosmetin |
| IUPAC: 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one | CAS: CAS:520-34-3 |
| Chembl ID: CHEMBL90568 | Pubchem ID: CID:5281612 |
| Formula: C16H12O6 | TCM-ID: TCMC1064 |
| Smiles: COc1ccc(cc1O)c1cc(=O)c2c(o1)cc(cc2O)O | |
| Alias:
Diosmetin;
Flavone, 3',5,7-trihydroxy-4'-methoxy-; 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 3',5,7-Trihydroxy-4'-methoxyflavone; 4'-Methylluteolin; 5,7,3'-Trihydroxy-4'-methoxyflavone; Diosmetine; Diosmetol; Luteolin 4'-methyl ether; Pillon |
Structure:
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Related Targets (Total: 8)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T43GWF | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 | PPIP5K1 |
Q6PFW1 |
A | 1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
B | 1 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
C | 1 Reference(s) |
| T02IOG | Cyclin-dependent kinase inhibitor 1B | CDKN1B |
P46527 |
C | 1 Reference(s) |
| T84FSA | Forkhead box protein O3 | FOXO3 |
O43524 |
C | 1 Reference(s) |
| T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
C | 1 Reference(s) |
| T75H3W | Cyclin-dependent kinase 2 | CDK2 |
P24941 |
C | 1 Reference(s) |
| T10S5F | Cyclin-dependent kinase 4 | CDK4 |
P11802 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 48)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0920 | Da Ban Bian Lian | 大半边莲 | Asian lobelia | Lobelia chinensis |
| H0931 | Da Ji Gen Jin Gao | 大蓟根浸膏 | NA | Herba cirsii japonici |
| H0140 | Lian Zi | 莲子 | Hindu lotus seed | Nelumbo nucifera |
| H0933 | Da Ji(1) | 大蓟 | NA | Herba cirsii japonici |
| H0782 | Zao Xiu | 蚤休 | NA | Paris polyphylla |
| H0818 | Zhi Zi | 栀子 | Cape jasmine fruit | Gardenia jasminoides |
| H1105 | Gua Lou Pi | 瓜蒌皮 | NA | Trichosanthes kirilowii |
| H0072 | Jing Jie | 荆芥 | Fineleaf schizonepeta | Schizonepeta tenuifolia |
| H0074 | Jing Jie Tan | 荆芥炭 | NA | Schizonepetae herba |
| H0233 | Mao Liang Mian Zhen | 毛两面针 | NA | Zanthoxylum nitidum |
| H0424 | Shan Zhi | 山栀 | Cape jasmine | Gardenia jasminoides |
| H1004 | Bai Cha | 白茶 | White tea | Camellia sinensis |
| H0322 | Qi Ye Yi Zhi Hua | 七叶一枝花 | rhizome of verticillate paris | Paris polyphylla |
| H0663 | Xiao Ji | 小蓟 | Setose thistle | Cirsium setosum |
| H0819 | Zhi Zi Jin Gao | 栀子浸膏 | Cape jasmine fruit | Gardenia jasminoides |
| H1164 | He Geng | 荷梗 | Hindu lotus petiole | Nelumbo nucifera |
| H0302 | Ou Fen | 藕粉 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0433 | She Ma Zi | 蛇麻子 | Common cnidium fruit | Cnidium monnieri |
| H1051 | Bai Guo | 白果 | Ginkgo nut | Ginkgo biloba |
| H0301 | Ou | 藕 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0729 | Ye Ju Hua | 野菊花 | Indian wild chrysanthemum flower | Chrysanthemum indicum |
| H0702 | Yan Bai Cai | 岩白菜 | Purple bergenia | Bergenia purpurascens |
| H0637 | Cha Ye | 茶叶 | Common tea | Camellia sinensis |
| H0979 | Di Yu | 地榆 | Garden burnet | Sanguisorba officinalis |
| H1194 | Hou Er Huan Jin Gao | 猴耳环浸膏 | NA | Pithecellobium clypearia |
| H1193 | Hou Er Huan Gan Jin Gao | 猴耳环干浸膏 | NA | Pithecellobium clypearia |
| H1106 | Gua Lou Ren | 瓜蒌仁 | NA | Trichosanthes kirilowii |
| H0430 | She Chuang Zi | 蛇床子 | Common cnidium | Cnidium monnieri |
| H1110 | Gua Lou Zi | 瓜蒌子 | mongolian snakegourd seed | Trichosanthes kirilowii maxim |
| H0141 | Lian Zi Xin | 莲子心 | Hindu lotus plumule | Nelumbo nucifera |
| H1112 | Gua Lou Ren(1) | 栝楼仁 | NA | Trichosanthes kirilowii |
| H0792 | Zhang Yu | 章鱼 | Common atlantic octopus | Octopus vulgaris |
| H1104 | Gua Lou | 瓜蒌 | NA | Trichosanthes kirilowii |
| H1107 | Gua Lou Ren Shuang | 瓜蒌仁霜 | NA | Trichosanthes kirilowii |
| H1192 | Hou Er Huan | 猴耳环 | NA | Pithecellobium clypearia |
| H1055 | Bai Guo Ren | 白果仁 | ginkgo | Ginkgo biloba |
| H0113 | Ban Bian Lian | 半边莲 | Chinese lobelia | Lobelia chinensis |
| H0750 | Yin Xing Ye | 银杏叶 | Folium ginkgo | Ginkgo biloba |
| H1111 | Gua Lou Gen | 栝楼根 | NA | Trichosanthes kirilowii |
| H0930 | Da Ji Gen | 大蓟根 | NA | Herba cirsii japonici |
| H1169 | He Ye | 荷叶 | Hindu lotus leaf | Nelumbo nucifera |
| H1124 | Guang Jin Qian Cao | 广金钱草 | Snowbellleaf tickclover | Desmodium styracifolium |
| H1108 | Gua Lou Shi | 栝蒌实 | NA | Trichosanthes kirilowii |
| H0304 | Ou Pian | 藕片 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0801 | Chong Bai La | 虫白蜡 | Cera chinensis wax | Ericerus pela |
| H0980 | Di Yu Tan | 地榆炭 | Garden burnet | Sanguisorba officinalis |
| H0258 | Mo Han Lian | 墨旱莲 | Yerbadetajo | Eclipta prostrata |
| H0539 | Tian Hua Fen | 天花粉 | Mongolian snakegourd root | Trichosanthes kirilowii |
Ckey description of the interaction between compound and target