HIT-result

Type	Detail
Target ID	T11TKN
Protein Name	Leucine-rich repeat serine/threonine-protein kinase 2
Uniprot ID	Q5S007
Protein Name Alias	EC 2.7.11.1; EC 3.6.5.-; Dardarin
Gene ID	120892
Gene Symbol	LRRK2
Gene Alias	PARK8
TTD	T08123: Clinical Trial target
Pfam	PF13855 ; PF12799 ; PF00069 ; PF16095
GO	0040012:regulation of locomotion 0005902:microvillus 0035641:locomotory exploration behavior 0043068:positive regulation of programmed cell death 0016310:phosphorylation 0006606:protein import into nucleus 0031410:cytoplasmic vesicle 0046039:GTP metabolic process 1902692:regulation of neuroblast proliferation 0043195:terminal bouton 1902823:negative regulation of late endosome to lysosome transport 1903125:negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation 0046777:protein autophosphorylation 1903217:negative regulation of protein processing involved in protein targeting to mitochondrion 0031267:small GTPase binding 0048812:neuron projection morphogenesis 0007283:spermatogenesis 0042391:regulation of membrane potential 2000300:regulation of synaptic vesicle exocytosis 1900244:positive regulation of synaptic vesicle endocytosis 0098978:glutamatergic synapse 0090394:negative regulation of excitatory postsynaptic potential 0000186:activation of MAPKK activity 0031398:positive regulation of protein ubiquitination 0005741:mitochondrial outer membrane 0034599:cellular response to oxidative stress 0042803:protein homodimerization activity 0010977:negative regulation of neuron projection development 0010738:regulation of protein kinase A signaling 0070997:neuron death 0000187:activation of MAPK activity 0034613:cellular protein localization 0005798:Golgi-associated vesicle 0001933:negative regulation of protein phosphorylation 0016301:kinase activity 0060070:canonical Wnt signaling pathway 0032839:dendrite cytoplasm 0000149:SNARE binding 0060079:excitatory postsynaptic potential 0004674:protein serine/threonine kinase activity 0035556:intracellular signal transduction 0030159:signaling receptor complex adaptor activity 0005524:ATP binding 0018107:peptidyl-threonine phosphorylation 0030425:dendrite 0006914:autophagy 0043025:neuronal cell body 2000172:regulation of branching morphogenesis of a nerve 0106311:protein threonine kinase activity 0051900:regulation of mitochondrial depolarization 1903206:negative regulation of hydrogen peroxide-induced cell death 0030426:growth cone 0060161:positive regulation of dopamine receptor signaling pathway 1901214:regulation of neuron death 0032436:positive regulation of proteasomal ubiquitin-dependent protein catabolic process 0042802:identical protein binding 0098794:postsynapse 1905289:regulation of CAMKK-AMPK signaling cascade 0036479:peroxidase inhibitor activity 1902803:regulation of synaptic vesicle transport 0070585:protein localization to mitochondrion 0004722:protein serine/threonine phosphatase activity 0051770:positive regulation of nitric-oxide synthase biosynthetic process 0061001:regulation of dendritic spine morphogenesis 1903215:negative regulation of protein targeting to mitochondrion 0005783:endoplasmic reticulum 0060159:regulation of dopamine receptor signaling pathway 0004672:protein kinase activity 1902499:positive regulation of protein autoubiquitination 0072593:reactive oxygen species metabolic process 0071287:cellular response to manganese ion 0090140:regulation of mitochondrial fission 0005759:mitochondrial matrix 0035564:regulation of kidney size 1905279:regulation of retrograde transport, endosome to Golgi 0030424:axon 0048312:intracellular distribution of mitochondria 0031647:regulation of protein stability 0090263:positive regulation of canonical Wnt signaling pathway 0099400:caveola neck 0021756:striatum development 0000165:MAPK cascade 0016234:inclusion body 0032092:positive regulation of protein binding 0044754:autolysosome 1990909:Wnt signalosome 0005743:mitochondrial inner membrane 0035751:regulation of lysosomal lumen pH 1990904:ribonucleoprotein complex 0014041:regulation of neuron maturation 0001934:positive regulation of protein phosphorylation 1903351:cellular response to dopamine 0007029:endoplasmic reticulum organization 0007005:mitochondrion organization 0060628:regulation of ER to Golgi vesicle-mediated transport 1903980:positive regulation of microglial cell activation 0021772:olfactory bulb development 1904887:Wnt signalosome assembly 0032473:cytoplasmic side of mitochondrial outer membrane 0005886:plasma membrane 0000287:magnesium ion binding 0140058:neuron projection arborization 0008340:determination of adult lifespan 0005768:endosome 0071407:cellular response to organic cyclic compound 0030276:clathrin binding 0044325:ion channel binding 1901215:negative regulation of neuron death 0005802:trans-Golgi network 0051966:regulation of synaptic transmission, glutamatergic 0070971:endoplasmic reticulum exit site 0005739:mitochondrion 0007040:lysosome organization 0034260:negative regulation of GTPase activity 0032091:negative regulation of protein binding 0003779:actin binding 0031966:mitochondrial membrane 0016242:negative regulation of macroautophagy 0008017:microtubule binding 0007165:signal transduction 1904713:beta-catenin destruction complex binding 0043406:positive regulation of MAP kinase activity 0010506:regulation of autophagy 0070062:extracellular exosome 0007528:neuromuscular junction development 0005789:endoplasmic reticulum membrane 0005615:extracellular space 0006468:protein phosphorylation 0009267:cellular response to starvation 0018105:peptidyl-serine phosphorylation 0005096:GTPase activator activity 0035640:exploration behavior 0005829:cytosol 0005764:lysosome 0099523:presynaptic cytosol 0015631:tubulin binding 0051646:mitochondrion localization 0010955:negative regulation of protein processing 0010508:positive regulation of autophagy 0005794:Golgi apparatus 0006897:endocytosis 0043204:perikaryon 0043005:neuron projection 0005737:cytoplasm 0030672:synaptic vesicle membrane 0004708:MAP kinase kinase activity 1902236:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 0060828:regulation of canonical Wnt signaling pathway 0044753:amphisome 0097487:multivesicular body, internal vesicle 0034211:GTP-dependent protein kinase activity 0017075:syntaxin-1 binding 0022028:tangential migration from the subventricular zone to the olfactory bulb 0045121:membrane raft 1901727:positive regulation of histone deacetylase activity 0005525:GTP binding 1902902:negative regulation of autophagosome assembly 0070973:protein localization to endoplasmic reticulum exit site 0106310:protein serine kinase activity 0000139:Golgi membrane 0043231:intracellular membrane-bounded organelle 0007030:Golgi organization 0039706:co-receptor binding 0019722:calcium-mediated signaling 0006979:response to oxidative stress 0003924:GTPase activity 0051018:protein kinase A binding
PDB	6OJF ; 6XR4 ; 6DLP ; 5MYC ; 6VNO ; 6VP7 ; 6OJE ; 6VP6 ; 2ZEJ ; 5MY9 ; 3D6T ; 6DLO
Drugbank	DB12010
KEGG	hsa:120892

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Name: Guanine

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Name: (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H0638	Xiang Bei	象贝	Fritillaria	Fritillaria thunbergii
H0843	Zi Bei Mu	紫贝母	NA	Fritillaria unibracteata
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0855	Chuan Bei Mu	川贝母	Fritillaria unibracteata	Fritillaria cirrhosa
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0311	Ping Bei Mu	平贝母	Ussuri fritillary	Fritillaria ussuriensis
H0152	Ling Zhi Jin Gao	灵芝浸膏	NA	Ganoderma lucidum
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0995	Dong Chong Xia Cao	冬虫夏草	Aweto	Cordyceps sinensis
H0859	Chuan Bei Mu Liu Jin Gao	川贝母流浸膏	Fritillaria unibracteata	Fritillaria cirrhosa
H0153	Ling Zhi(1)	灵芝	Lucid ganoderma	Ganoderma lucidum
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0735	Yi Bei Mu	伊贝母	Siberian fritillary equivalent plant: fritillaria walujewii	Fritillaria pallidiflora