HIT-result

Target Description

Type	Detail
Target ID	T68O49
Protein Name	Prostaglandin E2 receptor EP4 subtype
Uniprot ID	P35408
Protein Name Alias	PGE receptor EP4 subtype; PGE2 receptor EP4 subtype; Prostanoid EP4 receptor
Gene ID	5734
Gene Symbol	PTGER4
Gene Alias	PTGER2
TTD	T18876: Clinical Trial target
Pfam	PF00001
GO	0070371:ERK1 and ERK2 cascade 0007204:positive regulation of cytosolic calcium ion concentration 0002862:negative regulation of inflammatory response to antigenic stimulus 0071380:cellular response to prostaglandin E stimulus 0032496:response to lipopolysaccharide 2000420:negative regulation of eosinophil extravasation 0071260:cellular response to mechanical stimulus 0007186:G protein-coupled receptor signaling pathway 0060348:bone development 0001819:positive regulation of cytokine production 0033624:negative regulation of integrin activation 0005886:plasma membrane 0030278:regulation of ossification 0042093:T-helper cell differentiation 0004957:prostaglandin E receptor activity 0001818:negative regulation of cytokine production 0007188:adenylate cyclase-modulating G protein-coupled receptor signaling pathway 0051492:regulation of stress fiber assembly 0050728:negative regulation of inflammatory response 0050729:positive regulation of inflammatory response 0016021:integral component of membrane 0009612:response to mechanical stimulus 0006955:immune response 0007254:JNK cascade 0006954:inflammatory response 0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway
PDB	5YHL ; 5YWY ; 7D7M
Drugbank	DB12836 ; DB09211 ; DB00917 ; DB11113 ; DB00929
KEGG	hsa:5734

Type

Detail

Target ID

T68O49

Protein Name

Prostaglandin E2 receptor EP4 subtype

Uniprot ID

P35408

Protein Name Alias

PGE receptor EP4 subtype; PGE2 receptor EP4 subtype; Prostanoid EP4 receptor

Gene ID

5734

Gene Symbol

PTGER4

Gene Alias

PTGER2

TTD

T18876: Clinical Trial target

Pfam

PF00001

0070371:ERK1 and ERK2 cascade

0007204:positive regulation of cytosolic calcium ion concentration

0002862:negative regulation of inflammatory response to antigenic stimulus

0071380:cellular response to prostaglandin E stimulus

0032496:response to lipopolysaccharide

2000420:negative regulation of eosinophil extravasation

0071260:cellular response to mechanical stimulus

0007186:G protein-coupled receptor signaling pathway

0060348:bone development

0001819:positive regulation of cytokine production

0033624:negative regulation of integrin activation

0005886:plasma membrane

0030278:regulation of ossification

0042093:T-helper cell differentiation

0004957:prostaglandin E receptor activity

0001818:negative regulation of cytokine production

0007188:adenylate cyclase-modulating G protein-coupled receptor signaling pathway

0051492:regulation of stress fiber assembly

0050728:negative regulation of inflammatory response

0050729:positive regulation of inflammatory response

0016021:integral component of membrane

0009612:response to mechanical stimulus

0006955:immune response

0007254:JNK cascade

0006954:inflammatory response

0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway

PDB

5YHL ; 5YWY ; 7D7M

Drugbank

DB12836 ; DB09211 ; DB00917 ; DB11113 ; DB00929

KEGG

hsa:5734

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0437	She Xiang	麝香	Abelmusk	Moschus moschiferus
H0235	Mao She Xiang	毛麝香	Abelmusk	Moschus moschiferus
H0629	Xi Xin	细辛	Siebold wildginger	Asarum sieboldii
H0236	Mao She Xiang Jin Gao	毛麝香浸膏	Abelmusk	Moschus moschiferus
H0520	Tai Pan Fen	胎盘粉	Fetus powder	Human placenta
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0385	San Qi Ye Jing	三七叶茎	Sanchi	Panax notoginseng
H0356	Ren Gong She Xiang	人工麝香	Abelmusk	Moschus moschiferus
H0382	San Qi Hua	三七花	Sanchi	Panax notoginseng
H1102	Gu Sui Bu	骨碎补	Fortune’s drynaria rhizome	Drynaria fortunei
H0077	Jiu	酒	Ethanol	Vinum
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0521	Tai Pan Zu Zhi Fen	胎盘组织粉	NA	Human placenta
H0661	Xiao Hei Dou	小黑豆	Black turtle bean	Phaseolus vulgaris
H0383	San Qi Jing Ye	三七茎叶	Sanchi	Panax notoginseng
H0384	San Qi Ye	三七叶	Folium panax notoginseng	Panax notoginseng
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0380	San Qi Gan Jin Gao	三七干浸膏	Sanchi	Panax notoginseng
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0381	San Qi Gao Fen	三七膏粉	Sanchi	Panax notoginseng

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 23)