HIT-result

Target Description

Type	Detail
Target ID	T90QGN
Protein Name	T-cell-specific surface glycoprotein CD28
Uniprot ID	P10747
Protein Name Alias	TP44; CD antigen CD28
Gene ID	940
Gene Symbol	CD28
Gene Alias	NA
TTD	T85529: Successful target
Pfam	PF15910
GO	0002863:positive regulation of inflammatory response to antigenic stimulus 0048304:positive regulation of isotype switching to IgG isotypes 0010629:negative regulation of gene expression 0045066:regulatory T cell differentiation 0097190:apoptotic signaling pathway 0043066:negative regulation of apoptotic process 0042102:positive regulation of T cell proliferation 0009986:cell surface 0098636:protein complex involved in cell adhesion 0031295:T cell costimulation 0045060:negative thymic T cell selection 0045840:positive regulation of mitotic nuclear division 0005829:cytosol 0032733:positive regulation of interleukin-10 production 0001819:positive regulation of cytokine production 0045589:regulation of regulatory T cell differentiation 0042802:identical protein binding 0009897:external side of plasma membrane 0032743:positive regulation of interleukin-2 production 0032753:positive regulation of interleukin-4 production 0006959:humoral immune response 0007166:cell surface receptor signaling pathway 0042110:T cell activation 0005886:plasma membrane 0005887:integral component of plasma membrane 0045944:positive regulation of transcription by RNA polymerase II 0045070:positive regulation of viral genome replication 0046641:positive regulation of alpha-beta T cell proliferation 0002020:protease binding 0019901:protein kinase binding 0015026:coreceptor activity 0010628:positive regulation of gene expression 0014068:positive regulation of phosphatidylinositol 3-kinase signaling 0050690:regulation of defense response to virus by virus 0050852:T cell receptor signaling pathway 0001772:immunological synapse 0051897:positive regulation of protein kinase B signaling 0045727:positive regulation of translation
PDB	1YJD ; 5GJH ; 5AUL ; 3WA4 ; 5GJI ; 6O8D
Drugbank	NA
KEGG	hsa:940

Type

Detail

Target ID

T90QGN

Protein Name

T-cell-specific surface glycoprotein CD28

Uniprot ID

P10747

Protein Name Alias

TP44; CD antigen CD28

Gene ID

940

Gene Symbol

CD28

Gene Alias

TTD

T85529: Successful target

Pfam

PF15910

0002863:positive regulation of inflammatory response to antigenic stimulus

0048304:positive regulation of isotype switching to IgG isotypes

0010629:negative regulation of gene expression

0045066:regulatory T cell differentiation

0097190:apoptotic signaling pathway

0043066:negative regulation of apoptotic process

0042102:positive regulation of T cell proliferation

0009986:cell surface

0098636:protein complex involved in cell adhesion

0031295:T cell costimulation

0045060:negative thymic T cell selection

0045840:positive regulation of mitotic nuclear division

0005829:cytosol

0032733:positive regulation of interleukin-10 production

0001819:positive regulation of cytokine production

0045589:regulation of regulatory T cell differentiation

0042802:identical protein binding

0009897:external side of plasma membrane

0032743:positive regulation of interleukin-2 production

0032753:positive regulation of interleukin-4 production

0006959:humoral immune response

0007166:cell surface receptor signaling pathway

0042110:T cell activation

0005886:plasma membrane

0005887:integral component of plasma membrane

0045944:positive regulation of transcription by RNA polymerase II

0045070:positive regulation of viral genome replication

0046641:positive regulation of alpha-beta T cell proliferation

0002020:protease binding

0019901:protein kinase binding

0015026:coreceptor activity

0010628:positive regulation of gene expression

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0050690:regulation of defense response to virus by virus

0050852:T cell receptor signaling pathway

0001772:immunological synapse

0051897:positive regulation of protein kinase B signaling

0045727:positive regulation of translation

PDB

1YJD ; 5GJH ; 5AUL ; 3WA4 ; 5GJI ; 6O8D

Drugbank

KEGG

hsa:940

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0765	Chi Dou	赤豆	Assuki bean	Vigna angularis
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0434	She Pu Tao	蛇葡萄	Ampelopsis	Ampelopsis brevipedunculata
H0932	Ba Qia	菝葜	Chinaroot greenbrier	Smilax china
H1117	Guan Zhong	贯众	Male fern rhizome	Dryopteris crassirhizoma
H0617	Qian Cao Teng	茜草藤	NA	Rubia cordifolia
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0883	Chuan She Gan	川射干	Blackberrylily	Belamcanda chinensis
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H0432	She Gan	射干	Blackberrylily	Belamcanda chinensis
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0416	Shan Shen	山参	NA	Panax ginseng
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 32)