Target Description

Type Detail
Target ID T54D6L
Protein Name Angiopoietin-1
Uniprot ID Q15389
Protein Name Alias ANG-1
Gene ID 284
Gene Symbol ANGPT1
Gene Alias KIAA0003
TTD T44141: Clinical Trial target
Pfam PF00147
2000352:negative regulation of endothelial cell apoptotic process


0045785:positive regulation of cell adhesion

0002719:negative regulation of cytokine production involved in immune response

0034394:protein localization to cell surface

0050918:positive chemotaxis

0001934:positive regulation of protein phosphorylation

0043536:positive regulation of blood vessel endothelial cell migration

0030210:heparin biosynthetic process

0043122:regulation of I-kappaB kinase/NF-kappaB signaling

0001933:negative regulation of protein phosphorylation

0043524:negative regulation of neuron apoptotic process

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0043066:negative regulation of apoptotic process


0014842:regulation of skeletal muscle satellite cell proliferation

0010628:positive regulation of gene expression

0048014:Tie signaling pathway

0005615:extracellular space

0030154:cell differentiation

0050900:leukocyte migration

0002040:sprouting angiogenesis

0070062:extracellular exosome

1905605:positive regulation of blood-brain barrier permeability

0001701:in utero embryonic development

0045121:membrane raft

0072012:glomerulus vasculature development

0000165:MAPK cascade

0033138:positive regulation of peptidyl-serine phosphorylation

0030971:receptor tyrosine kinase binding

0070374:positive regulation of ERK1 and ERK2 cascade

0005576:extracellular region

0062023:collagen-containing extracellular matrix

0031589:cell-substrate adhesion

0032680:regulation of tumor necrosis factor production

0005102:signaling receptor binding

0010595:positive regulation of endothelial cell migration

0007171:activation of transmembrane receptor protein tyrosine kinase activity

0051897:positive regulation of protein kinase B signaling

0005886:plasma membrane

0043116:negative regulation of vascular permeability

0031398:positive regulation of protein ubiquitination

2000446:regulation of macrophage migration inhibitory factor signaling pathway

0043393:regulation of protein binding

0042308:negative regulation of protein import into nucleus

0007162:negative regulation of cell adhesion

0002092:positive regulation of receptor internalization


0014068:positive regulation of phosphatidylinositol 3-kinase signaling

PDB 4EPU ; 4JYO ; 4K0V
Drugbank NA
KEGG hsa:284

Related Compounds  (Total: 2)

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Name: Loperamide
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Name: (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione

Related Herbs  (Total: 7)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0028 Jiang Huang姜黄 Common turmericCurcuma longa