HIT-result

Target Description

Type	Detail
Target ID	T54D6L
Protein Name	Angiopoietin-1
Uniprot ID	Q15389
Protein Name Alias	ANG-1
Gene ID	284
Gene Symbol	ANGPT1
Gene Alias	KIAA0003
TTD	T44141: Clinical Trial target
Pfam	PF00147
GO	2000352:negative regulation of endothelial cell apoptotic process 0001525:angiogenesis 0045785:positive regulation of cell adhesion 0002719:negative regulation of cytokine production involved in immune response 0034394:protein localization to cell surface 0050918:positive chemotaxis 0001934:positive regulation of protein phosphorylation 0043536:positive regulation of blood vessel endothelial cell migration 0030210:heparin biosynthetic process 0043122:regulation of I-kappaB kinase/NF-kappaB signaling 0001933:negative regulation of protein phosphorylation 0043524:negative regulation of neuron apoptotic process 0050731:positive regulation of peptidyl-tyrosine phosphorylation 0043066:negative regulation of apoptotic process 0005902:microvillus 0014842:regulation of skeletal muscle satellite cell proliferation 0010628:positive regulation of gene expression 0048014:Tie signaling pathway 0005615:extracellular space 0030154:cell differentiation 0050900:leukocyte migration 0002040:sprouting angiogenesis 0070062:extracellular exosome 1905605:positive regulation of blood-brain barrier permeability 0001701:in utero embryonic development 0045121:membrane raft 0072012:glomerulus vasculature development 0000165:MAPK cascade 0033138:positive regulation of peptidyl-serine phosphorylation 0030971:receptor tyrosine kinase binding 0070374:positive regulation of ERK1 and ERK2 cascade 0005576:extracellular region 0062023:collagen-containing extracellular matrix 0031589:cell-substrate adhesion 0032680:regulation of tumor necrosis factor production 0005102:signaling receptor binding 0010595:positive regulation of endothelial cell migration 0007171:activation of transmembrane receptor protein tyrosine kinase activity 0051897:positive regulation of protein kinase B signaling 0005886:plasma membrane 0043116:negative regulation of vascular permeability 0031398:positive regulation of protein ubiquitination 2000446:regulation of macrophage migration inhibitory factor signaling pathway 0043393:regulation of protein binding 0042308:negative regulation of protein import into nucleus 0007162:negative regulation of cell adhesion 0002092:positive regulation of receptor internalization 0030097:hemopoiesis 0014068:positive regulation of phosphatidylinositol 3-kinase signaling
PDB	4EPU ; 4JYO ; 4K0V
Drugbank	NA
KEGG	hsa:284

Type

Detail

Target ID

T54D6L

Protein Name

Angiopoietin-1

Uniprot ID

Q15389

Protein Name Alias

ANG-1

Gene ID

284

Gene Symbol

ANGPT1

Gene Alias

KIAA0003

TTD

T44141: Clinical Trial target

Pfam

PF00147

2000352:negative regulation of endothelial cell apoptotic process

0001525:angiogenesis

0045785:positive regulation of cell adhesion

0002719:negative regulation of cytokine production involved in immune response

0034394:protein localization to cell surface

0050918:positive chemotaxis

0001934:positive regulation of protein phosphorylation

0043536:positive regulation of blood vessel endothelial cell migration

0030210:heparin biosynthetic process

0043122:regulation of I-kappaB kinase/NF-kappaB signaling

0001933:negative regulation of protein phosphorylation

0043524:negative regulation of neuron apoptotic process

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0043066:negative regulation of apoptotic process

0005902:microvillus

0014842:regulation of skeletal muscle satellite cell proliferation

0010628:positive regulation of gene expression

0048014:Tie signaling pathway

0005615:extracellular space

0030154:cell differentiation

0050900:leukocyte migration

0002040:sprouting angiogenesis

0070062:extracellular exosome

1905605:positive regulation of blood-brain barrier permeability

0001701:in utero embryonic development

0045121:membrane raft

0072012:glomerulus vasculature development

0000165:MAPK cascade

0033138:positive regulation of peptidyl-serine phosphorylation

0030971:receptor tyrosine kinase binding

0070374:positive regulation of ERK1 and ERK2 cascade

0005576:extracellular region

0062023:collagen-containing extracellular matrix

0031589:cell-substrate adhesion

0032680:regulation of tumor necrosis factor production

0005102:signaling receptor binding

0010595:positive regulation of endothelial cell migration

0007171:activation of transmembrane receptor protein tyrosine kinase activity

0051897:positive regulation of protein kinase B signaling

0005886:plasma membrane

0043116:negative regulation of vascular permeability

0031398:positive regulation of protein ubiquitination

2000446:regulation of macrophage migration inhibitory factor signaling pathway

0043393:regulation of protein binding

0042308:negative regulation of protein import into nucleus

0007162:negative regulation of cell adhesion

0002092:positive regulation of receptor internalization

0030097:hemopoiesis

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

PDB

4EPU ; 4JYO ; 4K0V

Drugbank

KEGG

hsa:284

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Name: Loperamide

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Name: (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 7)