HIT-result

Target Description

Type	Detail
Target ID	T28V82
Protein Name	Wilms tumor protein
Uniprot ID	P19544
Protein Name Alias	WT33
Gene ID	7490
Gene Symbol	WT1
Gene Alias	NA
TTD	T29960: Clinical Trial target
Pfam	PF02165 ; PF00096
GO	0006355:regulation of transcription, DNA-templated 0072112:glomerular visceral epithelial cell differentiation 2000020:positive regulation of male gonad development 0000976:transcription regulatory region sequence-specific DNA binding 0060923:cardiac muscle cell fate commitment 0072284:metanephric S-shaped body morphogenesis 0007530:sex determination 0043066:negative regulation of apoptotic process 0005730:nucleolus 0007507:heart development 0061032:visceral serous pericardium development 0044729:hemi-methylated DNA-binding 0072075:metanephric mesenchyme development 0010385:double-stranded methylated DNA binding 0060539:diaphragm development 0005829:cytosol 0001657:ureteric bud development 2000195:negative regulation of female gonad development 0043065:positive regulation of apoptotic process 0030308:negative regulation of cell growth 0060231:mesenchymal to epithelial transition 2001076:positive regulation of metanephric ureteric bud development 0007281:germ cell development 0001570:vasculogenesis 0001228:DNA-binding transcription activator activity, RNA polymerase II-specific 0005737:cytoplasm 0001658:branching involved in ureteric bud morphogenesis 0071320:cellular response to cAMP 1902895:positive regulation of pri-miRNA transcription by RNA polymerase II 0005654:nucleoplasm 0043565:sequence-specific DNA binding 0001822:kidney development 0070742:C2H2 zinc finger domain binding 0035802:adrenal cortex formation 0030855:epithelial cell differentiation 0045893:positive regulation of transcription, DNA-templated 0008270:zinc ion binding 0003723:RNA binding 0003700:DNA-binding transcription factor activity 0045944:positive regulation of transcription by RNA polymerase II 0016607:nuclear speck 0071371:cellular response to gonadotropin stimulus 0009888:tissue development 0005634:nucleus 0007356:thorax and anterior abdomen determination 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0008584:male gonad development 0032835:glomerulus development 0072302:negative regulation of metanephric glomerular mesangial cell proliferation 0072207:metanephric epithelium development 0010628:positive regulation of gene expression 0060421:positive regulation of heart growth 0017148:negative regulation of translation 0045892:negative regulation of transcription, DNA-templated 0030325:adrenal gland development 0008406:gonad development 0008380:RNA splicing 0003156:regulation of animal organ formation 1905643:positive regulation of DNA methylation 0032836:glomerular basement membrane development 0000122:negative regulation of transcription by RNA polymerase II 0008285:negative regulation of cell population proliferation 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0072166:posterior mesonephric tubule development 0043010:camera-type eye development 0030539:male genitalia development 0006357:regulation of transcription by RNA polymerase II
PDB	2JP9 ; 5KL6 ; 6BLW ; 1LU6 ; 4R2R ; 5KL4 ; 1XF7 ; 2G7W ; 4R2P ; 2JPA ; 5KL2 ; 5KL5 ; 4R2S ; 2G7X ; 6RSY ; 2G7T ; 4R2Q ; 4R2E ; 4WUU ; 6B0O ; 6B0R ; 2G7V ; 6B0P ; 2PRT ; 6B0Q ; 5KL3 ; 3MYJ ; 5KL7 ; 3HPJ
Drugbank	NA
KEGG	hsa:7490

Type

Detail

Target ID

T28V82

Protein Name

Wilms tumor protein

Uniprot ID

P19544

Protein Name Alias

WT33

Gene ID

7490

Gene Symbol

WT1

Gene Alias

TTD

T29960: Clinical Trial target

Pfam

PF02165 ; PF00096

0006355:regulation of transcription, DNA-templated

0072112:glomerular visceral epithelial cell differentiation

2000020:positive regulation of male gonad development

0000976:transcription regulatory region sequence-specific DNA binding

0060923:cardiac muscle cell fate commitment

0072284:metanephric S-shaped body morphogenesis

0007530:sex determination

0043066:negative regulation of apoptotic process

0005730:nucleolus

0007507:heart development

0061032:visceral serous pericardium development

0044729:hemi-methylated DNA-binding

0072075:metanephric mesenchyme development

0010385:double-stranded methylated DNA binding

0060539:diaphragm development

0005829:cytosol

0001657:ureteric bud development

2000195:negative regulation of female gonad development

0043065:positive regulation of apoptotic process

0030308:negative regulation of cell growth

0060231:mesenchymal to epithelial transition

2001076:positive regulation of metanephric ureteric bud development

0007281:germ cell development

0001570:vasculogenesis

0001228:DNA-binding transcription activator activity, RNA polymerase II-specific

0005737:cytoplasm

0001658:branching involved in ureteric bud morphogenesis

0071320:cellular response to cAMP

1902895:positive regulation of pri-miRNA transcription by RNA polymerase II

0005654:nucleoplasm

0043565:sequence-specific DNA binding

0001822:kidney development

0070742:C2H2 zinc finger domain binding

0035802:adrenal cortex formation

0030855:epithelial cell differentiation

0045893:positive regulation of transcription, DNA-templated

0008270:zinc ion binding

0003723:RNA binding

0003700:DNA-binding transcription factor activity

0045944:positive regulation of transcription by RNA polymerase II

0016607:nuclear speck

0071371:cellular response to gonadotropin stimulus

0009888:tissue development

0005634:nucleus

0007356:thorax and anterior abdomen determination

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0008584:male gonad development

0032835:glomerulus development

0072302:negative regulation of metanephric glomerular mesangial cell proliferation

0072207:metanephric epithelium development

0010628:positive regulation of gene expression

0060421:positive regulation of heart growth

0017148:negative regulation of translation

0045892:negative regulation of transcription, DNA-templated

0030325:adrenal gland development

0008406:gonad development

0008380:RNA splicing

0003156:regulation of animal organ formation

1905643:positive regulation of DNA methylation

0032836:glomerular basement membrane development

0000122:negative regulation of transcription by RNA polymerase II

0008285:negative regulation of cell population proliferation

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0072166:posterior mesonephric tubule development

0043010:camera-type eye development

0030539:male genitalia development

0006357:regulation of transcription by RNA polymerase II

PDB

2JP9 ; 5KL6 ; 6BLW ; 1LU6 ; 4R2R ; 5KL4 ; 1XF7 ; 2G7W ; 4R2P ; 2JPA ; 5KL2 ; 5KL5 ; 4R2S ; 2G7X ; 6RSY ; 2G7T ; 4R2Q ; 4R2E ; 4WUU ; 6B0O ; 6B0R ; 2G7V ; 6B0P ; 2PRT ; 6B0Q ; 5KL3 ; 3MYJ ; 5KL7 ; 3HPJ

Drugbank

KEGG

hsa:7490

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0064	Jin Yin Hua	金银花	Japanese honeysuckle	Lonicera japonica
H0958	Dang Shen	党参	Pilose asiabell	Codonopsis pilosula
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0370	Ru Xiang	乳香	Olibanum	Boswellia carterii
H0354	Ren Dong Teng	忍冬藤	Japanese honeysuckle vine	Lonicera japonica
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0065	Jin Yin Hua Ti Qu Ye	金银花提取液	Japanese honeysuckle	Lonicera japonica
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 15)