Target Description

Type Detail
Target ID T28V82
Protein Name Wilms tumor protein
Uniprot ID P19544
Protein Name Alias WT33
Gene ID 7490
Gene Symbol WT1
Gene Alias NA
TTD T29960: Clinical Trial target
Pfam PF02165 ; PF00096
0006355:regulation of transcription, DNA-templated

0072112:glomerular visceral epithelial cell differentiation

2000020:positive regulation of male gonad development

0000976:transcription regulatory region sequence-specific DNA binding

0060923:cardiac muscle cell fate commitment

0072284:metanephric S-shaped body morphogenesis

0007530:sex determination

0043066:negative regulation of apoptotic process


0007507:heart development

0061032:visceral serous pericardium development

0044729:hemi-methylated DNA-binding

0072075:metanephric mesenchyme development

0010385:double-stranded methylated DNA binding

0060539:diaphragm development


0001657:ureteric bud development

2000195:negative regulation of female gonad development

0043065:positive regulation of apoptotic process

0030308:negative regulation of cell growth

0060231:mesenchymal to epithelial transition

2001076:positive regulation of metanephric ureteric bud development

0007281:germ cell development


0001228:DNA-binding transcription activator activity, RNA polymerase II-specific


0001658:branching involved in ureteric bud morphogenesis

0071320:cellular response to cAMP

1902895:positive regulation of pri-miRNA transcription by RNA polymerase II


0043565:sequence-specific DNA binding

0001822:kidney development

0070742:C2H2 zinc finger domain binding

0035802:adrenal cortex formation

0030855:epithelial cell differentiation

0045893:positive regulation of transcription, DNA-templated

0008270:zinc ion binding

0003723:RNA binding

0003700:DNA-binding transcription factor activity

0045944:positive regulation of transcription by RNA polymerase II

0016607:nuclear speck

0071371:cellular response to gonadotropin stimulus

0009888:tissue development


0007356:thorax and anterior abdomen determination

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0008584:male gonad development

0032835:glomerulus development

0072302:negative regulation of metanephric glomerular mesangial cell proliferation

0072207:metanephric epithelium development

0010628:positive regulation of gene expression

0060421:positive regulation of heart growth

0017148:negative regulation of translation

0045892:negative regulation of transcription, DNA-templated

0030325:adrenal gland development

0008406:gonad development

0008380:RNA splicing

0003156:regulation of animal organ formation

1905643:positive regulation of DNA methylation

0032836:glomerular basement membrane development

0000122:negative regulation of transcription by RNA polymerase II

0008285:negative regulation of cell population proliferation

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0072166:posterior mesonephric tubule development

0043010:camera-type eye development

0030539:male genitalia development

0006357:regulation of transcription by RNA polymerase II

PDB 2JP9 ; 5KL6 ; 6BLW ; 1LU6 ; 4R2R ; 5KL4 ; 1XF7 ; 2G7W ; 4R2P ; 2JPA ; 5KL2 ; 5KL5 ; 4R2S ; 2G7X ; 6RSY ; 2G7T ; 4R2Q ; 4R2E ; 4WUU ; 6B0O ; 6B0R ; 2G7V ; 6B0P ; 2PRT ; 6B0Q ; 5KL3 ; 3MYJ ; 5KL7 ; 3HPJ
Drugbank NA
KEGG hsa:7490

Related Compounds  (Total: 3)

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Name: Progesterone
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Name: Fructose
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Name: (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione

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