HIT-result

Target Description

Type	Detail
Target ID	T34VFO
Protein Name	Platelet-derived growth factor receptor beta
Uniprot ID	P09619
Protein Name Alias	PDGF-R-beta; PDGFR-beta; EC 2.7.10.1; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1; PDGFR-1; CD antigen CD140b
Gene ID	5159
Gene Symbol	PDGFRB
Gene Alias	PDGFR; PDGFR1
TTD	T59102: Successful target
Pfam	PF00047 ; PF07679 ; PF07714
GO	0072262:metanephric glomerular mesangial cell proliferation involved in metanephros development 0009986:cell surface 0072075:metanephric mesenchyme development 0005102:signaling receptor binding 0005925:focal adhesion 0005161:platelet-derived growth factor receptor binding 0046777:protein autophosphorylation 0010863:positive regulation of phospholipase C activity 0035025:positive regulation of Rho protein signal transduction 0043548:phosphatidylinositol 3-kinase binding 0005019:platelet-derived growth factor beta-receptor activity 0048008:platelet-derived growth factor receptor signaling pathway 0033674:positive regulation of kinase activity 0032355:response to estradiol 0060437:lung growth 0061298:retina vasculature development in camera-type eye 0008584:male gonad development 0042060:wound healing 0090280:positive regulation of calcium ion import 0035793:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway 0004713:protein tyrosine kinase activity 0014911:positive regulation of smooth muscle cell migration 0005524:ATP binding 0072284:metanephric S-shaped body morphogenesis 0043066:negative regulation of apoptotic process 0016477:cell migration 0032956:regulation of actin cytoskeleton organization 2000573:positive regulation of DNA biosynthetic process 0072278:metanephric comma-shaped body morphogenesis 0060981:cell migration involved in coronary angiogenesis 0043552:positive regulation of phosphatidylinositol 3-kinase activity 0050921:positive regulation of chemotaxis 0055093:response to hyperoxia 0019899:enzyme binding 0055003:cardiac myofibril assembly 0043202:lysosomal lumen 0048839:inner ear development 0008284:positive regulation of cell population proliferation 0006024:glycosaminoglycan biosynthetic process 0051897:positive regulation of protein kinase B signaling 2000491:positive regulation of hepatic stellate cell activation 0048407:platelet-derived growth factor binding 0032516:positive regulation of phosphoprotein phosphatase activity 0000165:MAPK cascade 0048146:positive regulation of fibroblast proliferation 0016020:membrane 0035441:cell migration involved in vasculogenesis 0043627:response to estrogen 0019838:growth factor binding 0060326:cell chemotaxis 0035789:metanephric mesenchymal cell migration 0035909:aorta morphogenesis 0043065:positive regulation of apoptotic process 0005886:plasma membrane 0048661:positive regulation of smooth muscle cell proliferation 0034405:response to fluid shear stress 0005634:nucleus 0031226:intrinsic component of plasma membrane 0019901:protein kinase binding 0032967:positive regulation of collagen biosynthetic process 0005017:platelet-derived growth factor-activated receptor activity 0014068:positive regulation of phosphatidylinositol 3-kinase signaling 0046488:phosphatidylinositol metabolic process 0004992:platelet activating factor receptor activity 0007165:signal transduction 0043406:positive regulation of MAP kinase activity 0007568:aging 0016324:apical plasma membrane 0032526:response to retinoic acid 2000379:positive regulation of reactive oxygen species metabolic process 0009636:response to toxic substance 0018108:peptidyl-tyrosine phosphorylation 0007169:transmembrane receptor protein tyrosine kinase signaling pathway 0072277:metanephric glomerular capillary formation 0071670:smooth muscle cell chemotaxis 0042542:response to hydrogen peroxide 0007275:multicellular organism development 0045840:positive regulation of mitotic nuclear division 0038085:vascular endothelial growth factor binding 0038091:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway 0005794:Golgi apparatus 0005887:integral component of plasma membrane 0005737:cytoplasm 0030335:positive regulation of cell migration 0035791:platelet-derived growth factor receptor-beta signaling pathway 0043235:receptor complex 0048015:phosphatidylinositol-mediated signaling 0070374:positive regulation of ERK1 and ERK2 cascade 0043231:intracellular membrane-bounded organelle 0004714:transmembrane receptor protein tyrosine kinase activity 0031410:cytoplasmic vesicle
PDB	2PLD ; 1SHA ; 2PLE ; 1LWP ; 2L6W ; 1H9O ; 1GQ5 ; 3MJG ; 2IUI
Drugbank	DB01268 ; DB06589 ; DB05014 ; DB12978 ; DB15822 ; DB12147 ; DB01254 ; DB12010 ; DB09079 ; DB00619 ; DB06595 ; DB00398 ; DB08896 ; DB00102 ; DB09221 ; DB09283 ; DB05146 ; DB10770 ; DB14840
KEGG	hsa:5159

Type

Detail

Target ID

T34VFO

Protein Name

Platelet-derived growth factor receptor beta

Uniprot ID

P09619

Protein Name Alias

PDGF-R-beta; PDGFR-beta; EC 2.7.10.1; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1; PDGFR-1; CD antigen CD140b

Gene ID

5159

Gene Symbol

PDGFRB

Gene Alias

PDGFR; PDGFR1

TTD

T59102: Successful target

Pfam

PF00047 ; PF07679 ; PF07714

0072262:metanephric glomerular mesangial cell proliferation involved in metanephros development

0009986:cell surface

0072075:metanephric mesenchyme development

0005102:signaling receptor binding

0005925:focal adhesion

0005161:platelet-derived growth factor receptor binding

0046777:protein autophosphorylation

0010863:positive regulation of phospholipase C activity

0035025:positive regulation of Rho protein signal transduction

0043548:phosphatidylinositol 3-kinase binding

0005019:platelet-derived growth factor beta-receptor activity

0048008:platelet-derived growth factor receptor signaling pathway

0033674:positive regulation of kinase activity

0032355:response to estradiol

0060437:lung growth

0061298:retina vasculature development in camera-type eye

0008584:male gonad development

0042060:wound healing

0090280:positive regulation of calcium ion import

0035793:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

0004713:protein tyrosine kinase activity

0014911:positive regulation of smooth muscle cell migration

0005524:ATP binding

0072284:metanephric S-shaped body morphogenesis

0043066:negative regulation of apoptotic process

0016477:cell migration

0032956:regulation of actin cytoskeleton organization

2000573:positive regulation of DNA biosynthetic process

0072278:metanephric comma-shaped body morphogenesis

0060981:cell migration involved in coronary angiogenesis

0043552:positive regulation of phosphatidylinositol 3-kinase activity

0050921:positive regulation of chemotaxis

0055093:response to hyperoxia

0019899:enzyme binding

0055003:cardiac myofibril assembly

0043202:lysosomal lumen

0048839:inner ear development

0008284:positive regulation of cell population proliferation

0006024:glycosaminoglycan biosynthetic process

0051897:positive regulation of protein kinase B signaling

2000491:positive regulation of hepatic stellate cell activation

0048407:platelet-derived growth factor binding

0032516:positive regulation of phosphoprotein phosphatase activity

0000165:MAPK cascade

0048146:positive regulation of fibroblast proliferation

0016020:membrane

0035441:cell migration involved in vasculogenesis

0043627:response to estrogen

0019838:growth factor binding

0060326:cell chemotaxis

0035789:metanephric mesenchymal cell migration

0035909:aorta morphogenesis

0043065:positive regulation of apoptotic process

0005886:plasma membrane

0048661:positive regulation of smooth muscle cell proliferation

0034405:response to fluid shear stress

0005634:nucleus

0031226:intrinsic component of plasma membrane

0019901:protein kinase binding

0032967:positive regulation of collagen biosynthetic process

0005017:platelet-derived growth factor-activated receptor activity

0014068:positive regulation of phosphatidylinositol 3-kinase signaling

0046488:phosphatidylinositol metabolic process

0004992:platelet activating factor receptor activity

0007165:signal transduction

0043406:positive regulation of MAP kinase activity

0007568:aging

0016324:apical plasma membrane

0032526:response to retinoic acid

2000379:positive regulation of reactive oxygen species metabolic process

0009636:response to toxic substance

0018108:peptidyl-tyrosine phosphorylation

0007169:transmembrane receptor protein tyrosine kinase signaling pathway

0072277:metanephric glomerular capillary formation

0071670:smooth muscle cell chemotaxis

0042542:response to hydrogen peroxide

0007275:multicellular organism development

0045840:positive regulation of mitotic nuclear division

0038085:vascular endothelial growth factor binding

0038091:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

0005794:Golgi apparatus

0005887:integral component of plasma membrane

0005737:cytoplasm

0030335:positive regulation of cell migration

0035791:platelet-derived growth factor receptor-beta signaling pathway

0043235:receptor complex

0048015:phosphatidylinositol-mediated signaling

0070374:positive regulation of ERK1 and ERK2 cascade

0043231:intracellular membrane-bounded organelle

0004714:transmembrane receptor protein tyrosine kinase activity

0031410:cytoplasmic vesicle

PDB

2PLD ; 1SHA ; 2PLE ; 1LWP ; 2L6W ; 1H9O ; 1GQ5 ; 3MJG ; 2IUI

Drugbank

DB01268 ; DB06589 ; DB05014 ; DB12978 ; DB15822 ; DB12147 ; DB01254 ; DB12010 ; DB09079 ; DB00619 ; DB06595 ; DB00398 ; DB08896 ; DB00102 ; DB09221 ; DB09283 ; DB05146 ; DB10770 ; DB14840

KEGG

hsa:5159

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Name: Gambogic Acid

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Name: (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0114	Ku Xuan Shen	苦玄参	Common bitterfigwort	Picria felterrae
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0160	Liu Zhi	柳枝	Babylon weeping willow branch	Salix babylonica
H0258	Mo Han Lian	墨旱莲	Yerbadetajo	Eclipta prostrata
H0532	Teng Huang	藤黄	Gamboge tree resin	Garcinia morella
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 11)