HIT-result

Target Description

Type	Detail
Target ID	T58N83
Protein Name	Serine/threonine-protein kinase STK11
Uniprot ID	Q15831
Protein Name Alias	EC 2.7.11.1; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19
Gene ID	6794
Gene Symbol	STK11
Gene Alias	LKB1; PJS
TTD	NA
Pfam	PF00069
GO	0070062:extracellular exosome 0004674:protein serine/threonine kinase activity 0001558:regulation of cell growth 0001944:vasculature development 0006974:cellular response to DNA damage stimulus 0006470:protein dephosphorylation 0010212:response to ionizing radiation 1904262:negative regulation of TORC1 signaling 0005524:ATP binding 0006914:autophagy 0006468:protein phosphorylation 0032147:activation of protein kinase activity 0016020:membrane 0090090:negative regulation of canonical Wnt signaling pathway 0007409:axonogenesis 0120163:negative regulation of cold-induced thermogenesis 1901796:regulation of signal transduction by p53 class mediator 0030275:LRR domain binding 0106311:protein threonine kinase activity 0072332:intrinsic apoptotic signaling pathway by p53 class mediator 0051645:Golgi localization 0030010:establishment of cell polarity 0048814:regulation of dendrite morphogenesis 0005829:cytosol 0007050:cell cycle arrest 0046777:protein autophosphorylation 0030308:negative regulation of cell growth 0045059:positive thymic T cell selection 0007283:spermatogenesis 0060770:negative regulation of epithelial cell proliferation involved in prostate gland development 0010508:positive regulation of autophagy 0043276:anoikis 0000287:magnesium ion binding 0005737:cytoplasm 0042593:glucose homeostasis 0001894:tissue homeostasis 0005654:nucleoplasm 0097484:dendrite extension 0071493:cellular response to UV-B 0002039:p53 binding 0030295:protein kinase activator activity 0005739:mitochondrion 0005634:nucleus 0050772:positive regulation of axonogenesis 0030511:positive regulation of transforming growth factor beta receptor signaling pathway 1900182:positive regulation of protein localization to nucleus 0051896:regulation of protein kinase B signaling 0106310:protein serine kinase activity 0050852:T cell receptor signaling pathway 1901610:positive regulation of vesicle transport along microtubule 0008285:negative regulation of cell population proliferation 0060070:canonical Wnt signaling pathway
PDB	5WXN ; 2WTK ; 4ZDR
Drugbank	NA
KEGG	hsa:6794

Type

Detail

Target ID

T58N83

Protein Name

Serine/threonine-protein kinase STK11

Uniprot ID

Q15831

Protein Name Alias

EC 2.7.11.1; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19

Gene ID

6794

Gene Symbol

STK11

Gene Alias

LKB1; PJS

TTD

Pfam

PF00069

0070062:extracellular exosome

0004674:protein serine/threonine kinase activity

0001558:regulation of cell growth

0001944:vasculature development

0006974:cellular response to DNA damage stimulus

0006470:protein dephosphorylation

0010212:response to ionizing radiation

1904262:negative regulation of TORC1 signaling

0005524:ATP binding

0006914:autophagy

0006468:protein phosphorylation

0032147:activation of protein kinase activity

0016020:membrane

0090090:negative regulation of canonical Wnt signaling pathway

0007409:axonogenesis

0120163:negative regulation of cold-induced thermogenesis

1901796:regulation of signal transduction by p53 class mediator

0030275:LRR domain binding

0106311:protein threonine kinase activity

0072332:intrinsic apoptotic signaling pathway by p53 class mediator

0051645:Golgi localization

0030010:establishment of cell polarity

0048814:regulation of dendrite morphogenesis

0005829:cytosol

0007050:cell cycle arrest

0046777:protein autophosphorylation

0030308:negative regulation of cell growth

0045059:positive thymic T cell selection

0007283:spermatogenesis

0060770:negative regulation of epithelial cell proliferation involved in prostate gland development

0010508:positive regulation of autophagy

0043276:anoikis

0000287:magnesium ion binding

0005737:cytoplasm

0042593:glucose homeostasis

0001894:tissue homeostasis

0005654:nucleoplasm

0097484:dendrite extension

0071493:cellular response to UV-B

0002039:p53 binding

0030295:protein kinase activator activity

0005739:mitochondrion

0005634:nucleus

0050772:positive regulation of axonogenesis

0030511:positive regulation of transforming growth factor beta receptor signaling pathway

1900182:positive regulation of protein localization to nucleus

0051896:regulation of protein kinase B signaling

0106310:protein serine kinase activity

0050852:T cell receptor signaling pathway

1901610:positive regulation of vesicle transport along microtubule

0008285:negative regulation of cell population proliferation

0060070:canonical Wnt signaling pathway

PDB

5WXN ; 2WTK ; 4ZDR

Drugbank

KEGG

hsa:6794

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0521	Tai Pan Zu Zhi Fen	胎盘组织粉	NA	Human placenta
H0077	Jiu	酒	Ethanol	Vinum
H1102	Gu Sui Bu	骨碎补	Fortune’s drynaria rhizome	Drynaria fortunei
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0382	San Qi Hua	三七花	Sanchi	Panax notoginseng
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0520	Tai Pan Fen	胎盘粉	Fetus powder	Human placenta
H0437	She Xiang	麝香	Abelmusk	Moschus moschiferus
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0236	Mao She Xiang Jin Gao	毛麝香浸膏	Abelmusk	Moschus moschiferus
H0381	San Qi Gao Fen	三七膏粉	Sanchi	Panax notoginseng
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0356	Ren Gong She Xiang	人工麝香	Abelmusk	Moschus moschiferus
H0384	San Qi Ye	三七叶	Folium panax notoginseng	Panax notoginseng
H0235	Mao She Xiang	毛麝香	Abelmusk	Moschus moschiferus
H0661	Xiao Hei Dou	小黑豆	Black turtle bean	Phaseolus vulgaris
H0380	San Qi Gan Jin Gao	三七干浸膏	Sanchi	Panax notoginseng
H0385	San Qi Ye Jing	三七叶茎	Sanchi	Panax notoginseng
H0383	San Qi Jing Ye	三七茎叶	Sanchi	Panax notoginseng

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 22)