HIT-result

Target Description

Type	Detail
Target ID	T79KKF
Protein Name	Protein patched homolog 1
Uniprot ID	Q13635
Protein Name Alias	PTC; PTC1
Gene ID	5727
Gene Symbol	PTCH1
Gene Alias	PTCH
TTD	T30817: Research target
Pfam	PF02460
GO	0097421:liver regeneration 0042493:response to drug 0061005:cell differentiation involved in kidney development 0021522:spinal cord motor neuron differentiation 0060644:mammary gland epithelial cell differentiation 0001701:in utero embryonic development 0072203:cell proliferation involved in metanephros development 0003007:heart morphogenesis 0044294:dendritic growth cone 0016485:protein processing 0097108:hedgehog family protein binding 0048568:embryonic organ development 0043231:intracellular membrane-bounded organelle 0042593:glucose homeostasis 0030666:endocytic vesicle membrane 0045879:negative regulation of smoothened signaling pathway 0009953:dorsal/ventral pattern formation 0030326:embryonic limb morphogenesis 0005886:plasma membrane 0008158:hedgehog receptor activity 0008201:heparin binding 0016021:integral component of membrane 0072205:metanephric collecting duct development 0045893:positive regulation of transcription, DNA-templated 0000122:negative regulation of transcription by RNA polymerase II 0009887:animal organ morphogenesis 0009612:response to mechanical stimulus 0001658:branching involved in ureteric bud morphogenesis 0043616:keratinocyte proliferation 0021997:neural plate axis specification 0007224:smoothened signaling pathway 0005113:patched binding 0045177:apical part of cell 0048745:smooth muscle tissue development 0045668:negative regulation of osteoblast differentiation 0032880:regulation of protein localization 0048471:perinuclear region of cytoplasm 0005634:nucleus 0060170:ciliary membrane 0007420:brain development 0005901:caveola 0071397:cellular response to cholesterol 0035108:limb morphogenesis 0051782:negative regulation of cell division 0040015:negative regulation of multicellular organism growth 0021532:neural tube patterning 0010875:positive regulation of cholesterol efflux 0030850:prostate gland development 0007346:regulation of mitotic cell cycle 0035137:hindlimb morphogenesis 0060037:pharyngeal system development 0072659:protein localization to plasma membrane 0071679:commissural neuron axon guidance 0014069:postsynaptic density 0005119:smoothened binding 0010157:response to chlorate 0032355:response to estradiol 0043433:negative regulation of DNA-binding transcription factor activity 0061053:somite development 0032526:response to retinoic acid 0050680:negative regulation of epithelial cell proliferation 0015485:cholesterol binding 0030332:cyclin binding 0060603:mammary gland duct morphogenesis 0030496:midbody 0001709:cell fate determination 0009957:epidermal cell fate specification 0045606:positive regulation of epidermal cell differentiation 0008589:regulation of smoothened signaling pathway 0044877:protein-containing complex binding 0001843:neural tube closure 0044295:axonal growth cone 0060831:smoothened signaling pathway involved in dorsal/ventral neural tube patterning
PDB	6OEV ; 6RVD ; 6RTY ; 6RTX ; 6DMO ; 6E1H ; 6N7G ; 6RMG ; 6RVC ; 6DMY ; 6OEU ; 6DMB ; 6N7K ; 6RTW ; 6N7H
Drugbank	NA
KEGG	hsa:5727

Type

Detail

Target ID

T79KKF

Protein Name

Protein patched homolog 1

Uniprot ID

Q13635

Protein Name Alias

PTC; PTC1

Gene ID

5727

Gene Symbol

PTCH1

Gene Alias

PTCH

TTD

T30817: Research target

Pfam

PF02460

0097421:liver regeneration

0042493:response to drug

0061005:cell differentiation involved in kidney development

0021522:spinal cord motor neuron differentiation

0060644:mammary gland epithelial cell differentiation

0001701:in utero embryonic development

0072203:cell proliferation involved in metanephros development

0003007:heart morphogenesis

0044294:dendritic growth cone

0016485:protein processing

0097108:hedgehog family protein binding

0048568:embryonic organ development

0043231:intracellular membrane-bounded organelle

0042593:glucose homeostasis

0030666:endocytic vesicle membrane

0045879:negative regulation of smoothened signaling pathway

0009953:dorsal/ventral pattern formation

0030326:embryonic limb morphogenesis

0005886:plasma membrane

0008158:hedgehog receptor activity

0008201:heparin binding

0016021:integral component of membrane

0072205:metanephric collecting duct development

0045893:positive regulation of transcription, DNA-templated

0000122:negative regulation of transcription by RNA polymerase II

0009887:animal organ morphogenesis

0009612:response to mechanical stimulus

0001658:branching involved in ureteric bud morphogenesis

0043616:keratinocyte proliferation

0021997:neural plate axis specification

0007224:smoothened signaling pathway

0005113:patched binding

0045177:apical part of cell

0048745:smooth muscle tissue development

0045668:negative regulation of osteoblast differentiation

0032880:regulation of protein localization

0048471:perinuclear region of cytoplasm

0005634:nucleus

0060170:ciliary membrane

0007420:brain development

0005901:caveola

0071397:cellular response to cholesterol

0035108:limb morphogenesis

0051782:negative regulation of cell division

0040015:negative regulation of multicellular organism growth

0021532:neural tube patterning

0010875:positive regulation of cholesterol efflux

0030850:prostate gland development

0007346:regulation of mitotic cell cycle

0035137:hindlimb morphogenesis

0060037:pharyngeal system development

0072659:protein localization to plasma membrane

0071679:commissural neuron axon guidance

0014069:postsynaptic density

0005119:smoothened binding

0010157:response to chlorate

0032355:response to estradiol

0043433:negative regulation of DNA-binding transcription factor activity

0061053:somite development

0032526:response to retinoic acid

0050680:negative regulation of epithelial cell proliferation

0015485:cholesterol binding

0030332:cyclin binding

0060603:mammary gland duct morphogenesis

0030496:midbody

0001709:cell fate determination

0009957:epidermal cell fate specification

0045606:positive regulation of epidermal cell differentiation

0008589:regulation of smoothened signaling pathway

0044877:protein-containing complex binding

0001843:neural tube closure

0044295:axonal growth cone

0060831:smoothened signaling pathway involved in dorsal/ventral neural tube patterning

PDB

6OEV ; 6RVD ; 6RTY ; 6RTX ; 6DMO ; 6E1H ; 6N7G ; 6RMG ; 6RVC ; 6DMY ; 6OEU ; 6DMB ; 6N7K ; 6RTW ; 6N7H

Drugbank

KEGG

hsa:5727

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Name: (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 7)