HIT-result

Target Description

Type	Detail
Target ID	T42Q3K
Protein Name	Aspartate aminotransferase, cytoplasmic
Uniprot ID	P17174
Protein Name Alias	cAspAT; EC 2.6.1.1; EC 2.6.1.3; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A
Gene ID	2805
Gene Symbol	GOT1
Gene Alias	NA
TTD	T33367: Research target
Pfam	PF00155
GO	0043679:axon terminus 0005654:nucleoplasm 0006103:2-oxoglutarate metabolic process 0006536:glutamate metabolic process 0030170:pyridoxal phosphate binding 0032869:cellular response to insulin stimulus 0004609:phosphatidylserine decarboxylase activity 0046686:response to cadmium ion 0055089:fatty acid homeostasis 0051902:negative regulation of mitochondrial depolarization 0030511:positive regulation of transforming growth factor beta receptor signaling pathway 0032966:negative regulation of collagen biosynthetic process 0007219:Notch signaling pathway 0005829:cytosol 0070062:extracellular exosome 0019551:glutamate catabolic process to 2-oxoglutarate 0009743:response to carbohydrate 0009066:aspartate family amino acid metabolic process 0006094:gluconeogenesis 0019550:glutamate catabolic process to aspartate 0005764:lysosome 0005634:nucleus 0006107:oxaloacetate metabolic process 0035902:response to immobilization stress 1990267:response to transition metal nanoparticle 0006114:glycerol biosynthetic process 0004069:L-aspartate:2-oxoglutarate aminotransferase activity 0006533:aspartate catabolic process 0071260:cellular response to mechanical stimulus 0051384:response to glucocorticoid 0047801:L-cysteine:2-oxoglutarate aminotransferase activity 0060290:transdifferentiation 0005737:cytoplasm 0006532:aspartate biosynthetic process 0051481:negative regulation of cytosolic calcium ion concentration 0031406:carboxylic acid binding 0006531:aspartate metabolic process
PDB	3II0 ; 6LIG ; 6DNA ; 6DND ; 3WZF ; 6DNB
Drugbank	DB00128 ; DB00142 ; DB09130 ; DB00151 ; DB04299 ; DB00114 ; DB00210
KEGG	hsa:2805

Type

Detail

Target ID

T42Q3K

Protein Name

Aspartate aminotransferase, cytoplasmic

Uniprot ID

P17174

Protein Name Alias

cAspAT; EC 2.6.1.1; EC 2.6.1.3; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A

Gene ID

2805

Gene Symbol

GOT1

Gene Alias

TTD

T33367: Research target

Pfam

PF00155

0043679:axon terminus

0005654:nucleoplasm

0006103:2-oxoglutarate metabolic process

0006536:glutamate metabolic process

0030170:pyridoxal phosphate binding

0032869:cellular response to insulin stimulus

0004609:phosphatidylserine decarboxylase activity

0046686:response to cadmium ion

0055089:fatty acid homeostasis

0051902:negative regulation of mitochondrial depolarization

0030511:positive regulation of transforming growth factor beta receptor signaling pathway

0032966:negative regulation of collagen biosynthetic process

0007219:Notch signaling pathway

0005829:cytosol

0070062:extracellular exosome

0019551:glutamate catabolic process to 2-oxoglutarate

0009743:response to carbohydrate

0009066:aspartate family amino acid metabolic process

0006094:gluconeogenesis

0019550:glutamate catabolic process to aspartate

0005764:lysosome

0005634:nucleus

0006107:oxaloacetate metabolic process

0035902:response to immobilization stress

1990267:response to transition metal nanoparticle

0006114:glycerol biosynthetic process

0004069:L-aspartate:2-oxoglutarate aminotransferase activity

0006533:aspartate catabolic process

0071260:cellular response to mechanical stimulus

0051384:response to glucocorticoid

0047801:L-cysteine:2-oxoglutarate aminotransferase activity

0060290:transdifferentiation

0005737:cytoplasm

0006532:aspartate biosynthetic process

0051481:negative regulation of cytosolic calcium ion concentration

0031406:carboxylic acid binding

0006531:aspartate metabolic process

PDB

3II0 ; 6LIG ; 6DNA ; 6DND ; 3WZF ; 6DNB

Drugbank

DB00128 ; DB00142 ; DB09130 ; DB00151 ; DB04299 ; DB00114 ; DB00210

KEGG

hsa:2805

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1207	Hu Ma	胡麻	white seed of oriental sesame	Sesamum indicum
H1208	Hu Ma Ren	胡麻仁	white seed of oriental sesame	Sesamum indicum
H0295	Bi Ba	荜茇	Long pepper	Piper longum
H0808	Zhi Ma You	芝麻油	oil of oriental sesame	Oleum sesami
H0209	Ma You	麻油	Sesame oil	Oleum sesami
H0910	Ci Wu Jia Jin Gao	刺五加浸膏	Manypr ickle acanthopana x	Eleutherococcus senticosus
H0806	Zhi Ma	芝麻	white seed of oriental sesame	Semen sesami
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0909	Ci Wu Jia Gao	刺五加膏	Manypr ickle acanthopana x	Eleutherococcus senticosus
H0629	Xi Xin	细辛	Siebold wildginger	Asarum sieboldii
H0573	Tu Jia Pi	土加皮	NA	Acanthopanax gracilistylus
H0913	Ci Wu Jia Qing Gao	刺五加清膏	Manypr ickle acanthopana x	Eleutherococcus senticosus
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0912	Ci Wu Jia Jin Yu	刺五加浸育	Manypr ickle acanthopana x	Eleutherococcus senticosus
H0908	Ci Wu Jia	刺五加	Manypr ickle acanthopana x	Eleutherococcus senticosus
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0584	Tu Wu Jia	土五加	NA	Acanthopanax gracilistylus
H1181	Hei Zhi Ma	黑芝麻	Oriental sesame	Sesamum indicum
H0597	Wu Jia Pi	五加皮	Slenderstyle acanthopanax root-bark	Acanthopanax gracilistylus
H0535	Teng Wu Jia Gen	藤五加根	NA	Acanthopanax gracilistylus

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 20)