Target Description
| Type | Detail |
|---|---|
| Target ID | T95A39 |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
| Uniprot ID |
P09936 |
| Protein Name Alias | UCH-L1; EC 3.4.19.12; Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; Ubiquitin thioesterase L1 |
| Gene ID |
7345 |
| Gene Symbol | UCHL1 |
| Gene Alias | NA |
| TTD | T56051: Preclinical target |
| Pfam | PF01088 |
| GO |
0004197:cysteine-type endopeptidase activity
0005654:nucleoplasm 0005789:endoplasmic reticulum membrane 0005829:cytosol 0043130:ubiquitin binding 0031625:ubiquitin protein ligase binding 0016874:ligase activity 0043407:negative regulation of MAP kinase activity 0004843:thiol-dependent ubiquitin-specific protease activity 0043161:proteasome-mediated ubiquitin-dependent protein catabolic process 0016241:regulation of macroautophagy 0008242:omega peptidase activity 0016579:protein deubiquitination 0031694:alpha-2A adrenergic receptor binding 0005737:cytoplasm |
| PDB | 2LEN ; 3IRT ; 2ETL ; 3IFW ; 4JKJ ; 3KW5 ; 4DM9 ; 3KVF |
| Drugbank | DB12695 |
| KEGG | hsa:7345 |
Related Herbs (Total: 32)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0416 | Shan Shen | 山参 | NA | Panax ginseng |
| H0629 | Xi Xin | 细辛 | Siebold wildginger | Asarum sieboldii |
| H1051 | Bai Guo | 白果 | Ginkgo nut | Ginkgo biloba |
| H0095 | Gou Qi Zi | 枸杞子 | Chinese wolfberry fruit | Lycium chinense |
| H0607 | Wu Wei Zi Jin Chu Wu | 五味子浸出物 | Five-flavor berry | Schisandra chinensis |
| H0301 | Ou | 藕 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0094 | Gou Qi | 枸杞 | Chinese wolfberry fruit | Lycium chinense |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H0956 | Dang Gui Gan Jin Gao | 当归干浸膏 | NA | Angelica sinensis |
| H0304 | Ou Pian | 藕片 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0605 | Wu Wei Zi | 五味子 | Chinese magnoliavine | Schisandra chinensis |
| H0609 | Wu Wei Zi Liu Jin Gao | 五味子流浸膏 | Five-flavor berry | Schisandra chinensis |
| H1164 | He Geng | 荷梗 | Hindu lotus petiole | Nelumbo nucifera |
| H0104 | Bai Zhu | 白术 | Largehead atractylodes | Atractylodes macrocephala |
| H0302 | Ou Fen | 藕粉 | Hindu lotus large rhizome | Nelumbo nucifera |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H0140 | Lian Zi | 莲子 | Hindu lotus seed | Nelumbo nucifera |
| H0358 | Ren Shen Ye | 人参叶 | Ginseng leaf | Panax ginseng |
| H0955 | Dang Gui | 当归 | Chinese angelica | Angelica sinensis |
| H0056 | Jin Qiao Mai | 金荞麦 | Wild buckwheat rhizome | Rhizoma fagopyri cymosi |
| H0396 | Sang Ye | 桑叶 | White mulberry leaf | Morus alba |
| H1169 | He Ye | 荷叶 | Hindu lotus leaf | Nelumbo nucifera |
| H0141 | Lian Zi Xin | 莲子心 | Hindu lotus plumule | Nelumbo nucifera |
| H0606 | Wu Wei Zi Chun Jin Gao | 五味子醇浸膏 | Five-flavor berry | Schisandra chinensis |
| H0391 | Sang Pi | 桑皮 | Prepared root-bark white mulberry | Morus alba |
| H0551 | Cang Zhu | 苍术 | Swordlike atractylodes | Atractylodes lancea |
| H1055 | Bai Guo Ren | 白果仁 | ginkgo | Ginkgo biloba |
| H0397 | Sang Zhi | 桑枝 | White mulberry branch | Morus alba |
| H0750 | Yin Xing Ye | 银杏叶 | Folium ginkgo | Ginkgo biloba |
| H0608 | Wu Wei Zi Jin Gao | 五味子浸膏 | Five-flavor berry | Schisandra chinensis |
| H0357 | Ren Shen | 人参 | Ginseng | Panax ginseng |
| H0640 | Xiang Fu | 香附 | Nutgrass galingale | Cyperus rotundus |