HIT-result

Type	Detail
Target ID	T40EUL
Protein Name	Transient receptor potential cation channel subfamily V member 4
Uniprot ID	Q9HBA0
Protein Name Alias	TrpV4; Osm-9-like TRP channel 4; OTRPC4; Transient receptor potential protein 12; TRP12; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; VRL-2; Vanilloid receptor-related osmotically-activated channel; VR-OAC
Gene ID	59341
Gene Symbol	TRPV4
Gene Alias	VRL2; VROAC
TTD	T64213: Clinical Trial target
Pfam	PF00023 ; PF00520
GO	0046872:metal ion binding 0006816:calcium ion transport 0034605:cellular response to heat 0005929:cilium 0048487:beta-tubulin binding 0070509:calcium ion import 0030864:cortical actin cytoskeleton 0005262:calcium channel activity 0008017:microtubule binding 0097497:blood vessel endothelial cell delamination 0046785:microtubule polymerization 0031117:positive regulation of microtubule depolymerization 0098703:calcium ion import across plasma membrane 0006884:cell volume homeostasis 0043117:positive regulation of vascular permeability 0007204:positive regulation of cytosolic calcium ion concentration 0042802:identical protein binding 0050891:multicellular organismal water homeostasis 0071470:cellular response to osmotic stress 0010977:negative regulation of neuron projection development 0071476:cellular hypotonic response 0005783:endoplasmic reticulum 0005912:adherens junction 0051015:actin filament binding 0005524:ATP binding 0016021:integral component of membrane 0007043:cell-cell junction assembly 0016324:apical plasma membrane 0005261:cation channel activity 0005080:protein kinase C binding 0007231:osmosensory signaling pathway 0005216:ion channel activity 0006874:cellular calcium ion homeostasis 0031532:actin cytoskeleton reorganization 0015275:stretch-activated, cation-selective, calcium channel activity 0007015:actin filament organization 0009612:response to mechanical stimulus 0005925:focal adhesion 0030027:lamellipodium 0043014:alpha-tubulin binding 1902656:calcium ion import into cytosol 0030426:growth cone 0042169:SH2 domain binding 0005886:plasma membrane 0008289:lipid binding 0030175:filopodium 0005887:integral component of plasma membrane 0019901:protein kinase binding 0060351:cartilage development involved in endochondral bone morphogenesis 0005516:calmodulin binding 0032587:ruffle membrane 0003779:actin binding 0043622:cortical microtubule organization 0070588:calcium ion transmembrane transport
PDB	4DX1 ; 4DX2
Drugbank	DB11148 ; DB14011 ; DB09061 ; DB14009
KEGG	hsa:59341

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0004	Huo Xiang	藿香	Patchouli	Pogostemon cablin
H0919	Cui Yun Cao	翠云草	Hooked spikemoss	Selaginella uncinata
H0416	Shan Shen	山参	NA	Panax ginseng
H0747	An Xi Xiang	安息香	Sumatra snowbel	Styrax benzoin
H0338	Qing Ban Xia	清半夏	Ternate pinellia	Pinellia ternata
H1123	Guang Huo Xiang You	广藿香油	oil of cabline potchouli	Oleum pogostemonis
H0155	Ban Xia	半夏	Ternate pinellia	Pinellia ternata
H0159	Ban Xia Qu	半夏曲	Pinellia tuber leaven	Pinellia ternata
H1051	Bai Guo	白果	Ginkgo nut	Ginkgo biloba
H0461	Shi Jun Zi Ren	使君子仁	NA	Combretum indicum
H0261	Mo Yao	没药	Myrrh	Commiphora myrrha
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0673	Xin Jiang Zi Cao	新疆紫草	Arnebia root	Arnebia euchroma
H0956	Dang Gui Gan Jin Gao	当归干浸膏	NA	Angelica sinensis
H0204	Ma Ren	麻仁	NA	Cannabis sativa
H0990	Ding Xiang	丁香	Clove tree	Syzygium aromaticum
H0367	Rou Gui Ye	肉桂叶	Cassia bark oil	Oleum cinnamomi
H0368	Rou Gui Zi	肉桂子	Cassiabarktree	Cinnamomum cassia
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H1135	Gui Pi	桂皮	Japanese cinnamon	Cinnamomum japonicum
H1122	Guang Huo Xiang Ye	广藿香叶	leaf of cabline potchouli	Folium pogostemonis
H0366	Rou Gui	肉桂	Cassiabarktree	Cinnamomum cassia
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0522	Tai Zi Shen	太子参	Heterophylly falsestarwort root	Radix pseudostellariae
H0005	Huo Xiang Ye	藿香叶	Patchouli	Pogostemon cablin
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0273	Mu Tong	木通	Fiveleaf akebia	Akebia quinata
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0572	Tu Huo Xiang	土藿香	Patchouli	Pogostemon cablin
H1114	Guan Gui	官桂	Cassiabarktree	Cinnamomum cassia
H0003	Huo Ma Ren	火麻仁	Hemp fimble seed	Cannabis sativa
H0439	Sheng Ban Xia	生半夏	Ternate pinellia	Pinellia ternata
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H1120	Guang Huo Xiang	广藿香	Patchouli	Pogostemon cablin
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0510	Su He Xiang	苏合香	Oriental sweetgum resin	Liquidambar orientalis
H0955	Dang Gui	当归	Chinese angelica	Angelica sinensis
H0415	Shan Nai	山柰	Galanga resurrectionlily	Kaempferia galanga
H0844	Zi Cao	紫草	Redroot gromwell	Lithospermum erythrorhizon
H1055	Bai Guo Ren	白果仁	ginkgo	Ginkgo biloba
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0260	Mo Xiang	没香	Myrrh	Commiphora myrrha
H1136	Gui Pi You	桂皮油	Cinnamon oil	Oleum corticis cinnamomi
H0750	Yin Xing Ye	银杏叶	Folium ginkgo	Ginkgo biloba
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H1010	Du Huo Xiang	杜藿香	Patchouli	Pogostemon cablin
H1139	Gui Zhi	桂枝	Cassiabarktree twig	Cinnamomum cassia
H1097	Gong Ding Xiang	公丁香	NA	Syzygium aromaticum
H0237	Mei Gui Hua	玫瑰花	Rugose rose flower	Rosa rugosa

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 53)