HIT-result

Target Description

Type	Detail
Target ID	T56FPY
Protein Name	CD81 antigen
Uniprot ID	P60033
Protein Name Alias	26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD antigen CD81
Gene ID	975
Gene Symbol	CD81
Gene Alias	TAPA1; TSPAN28
TTD	NA
Pfam	PF00335
GO	0046813:receptor-mediated virion attachment to host cell 2000563:positive regulation of CD4-positive, alpha-beta T cell proliferation 0008104:protein localization 0070062:extracellular exosome 0005925:focal adhesion 0070863:positive regulation of protein exit from endoplasmic reticulum 0030449:regulation of complement activation 0097197:tetraspanin-enriched microdomain 0071404:cellular response to low-density lipoprotein particle stimulus 0008284:positive regulation of cell population proliferation 0002455:humoral immune response mediated by circulating immunoglobulin 0023026:MHC class II protein complex binding 0000187:activation of MAPK activity 2001190:positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 0031623:receptor internalization 2000553:positive regulation of T-helper 2 cell cytokine production 0050776:regulation of immune response 0005887:integral component of plasma membrane 0005886:plasma membrane 0050731:positive regulation of peptidyl-tyrosine phosphorylation 0043128:positive regulation of 1-phosphatidylinositol 4-kinase activity 0072675:osteoclast fusion 0050862:positive regulation of T cell receptor signaling pathway 0016021:integral component of membrane 0031982:vesicle 0014905:myoblast fusion involved in skeletal muscle regeneration 0002863:positive regulation of inflammatory response to antigenic stimulus 0015485:cholesterol binding 0046718:viral entry into host cell 0035783:CD4-positive, alpha-beta T cell costimulation 0009925:basal plasma membrane 0016020:membrane 0005178:integrin binding 0072659:protein localization to plasma membrane 0061462:protein localization to lysosome 0050861:positive regulation of B cell receptor signaling pathway 0034238:macrophage fusion 0042289:MHC class II protein binding 0001772:immunological synapse 0030890:positive regulation of B cell proliferation 0031647:regulation of protein stability 1904352:positive regulation of protein catabolic process in the vacuole 0016323:basolateral plasma membrane 0001618:virus receptor activity 1905521:regulation of macrophage migration 1903911:positive regulation of receptor clustering 0045944:positive regulation of transcription by RNA polymerase II 1990459:transferrin receptor binding 0001771:immunological synapse formation 1905676:positive regulation of adaptive immune memory response
PDB	5M3D ; 5M33 ; 6U9S ; 1IV5 ; 5M2C ; 6EJM ; 2AVZ ; 5M3T ; 5TCX ; 6EJG ; 6EK2 ; 3X0E ; 1G8Q ; 5DFW ; 5DFV ; 5M4R
Drugbank	NA
KEGG	hsa:975

Type

Detail

Target ID

T56FPY

Protein Name

CD81 antigen

Uniprot ID

P60033

Protein Name Alias

26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD antigen CD81

Gene ID

975

Gene Symbol

CD81

Gene Alias

TAPA1; TSPAN28

TTD

Pfam

PF00335

0046813:receptor-mediated virion attachment to host cell

2000563:positive regulation of CD4-positive, alpha-beta T cell proliferation

0008104:protein localization

0070062:extracellular exosome

0005925:focal adhesion

0070863:positive regulation of protein exit from endoplasmic reticulum

0030449:regulation of complement activation

0097197:tetraspanin-enriched microdomain

0071404:cellular response to low-density lipoprotein particle stimulus

0008284:positive regulation of cell population proliferation

0002455:humoral immune response mediated by circulating immunoglobulin

0023026:MHC class II protein complex binding

0000187:activation of MAPK activity

2001190:positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

0031623:receptor internalization

2000553:positive regulation of T-helper 2 cell cytokine production

0050776:regulation of immune response

0005887:integral component of plasma membrane

0005886:plasma membrane

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0043128:positive regulation of 1-phosphatidylinositol 4-kinase activity

0072675:osteoclast fusion

0050862:positive regulation of T cell receptor signaling pathway

0016021:integral component of membrane

0031982:vesicle

0014905:myoblast fusion involved in skeletal muscle regeneration

0002863:positive regulation of inflammatory response to antigenic stimulus

0015485:cholesterol binding

0046718:viral entry into host cell

0035783:CD4-positive, alpha-beta T cell costimulation

0009925:basal plasma membrane

0016020:membrane

0005178:integrin binding

0072659:protein localization to plasma membrane

0061462:protein localization to lysosome

0050861:positive regulation of B cell receptor signaling pathway

0034238:macrophage fusion

0042289:MHC class II protein binding

0001772:immunological synapse

0030890:positive regulation of B cell proliferation

0031647:regulation of protein stability

1904352:positive regulation of protein catabolic process in the vacuole

0016323:basolateral plasma membrane

0001618:virus receptor activity

1905521:regulation of macrophage migration

1903911:positive regulation of receptor clustering

0045944:positive regulation of transcription by RNA polymerase II

1990459:transferrin receptor binding

0001771:immunological synapse formation

1905676:positive regulation of adaptive immune memory response

PDB

5M3D ; 5M33 ; 6U9S ; 1IV5 ; 5M2C ; 6EJM ; 2AVZ ; 5M3T ; 5TCX ; 6EJG ; 6EK2 ; 3X0E ; 1G8Q ; 5DFW ; 5DFV ; 5M4R

Drugbank

KEGG

hsa:975

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H0607	Wu Wei Zi Jin Chu Wu	五味子浸出物	Five-flavor berry	Schisandra chinensis
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0287	Nao Yang Hua	闹羊花	Chinese azalea	Rhododendron molle
H0648	Xiang Si Teng	相思藤	Coralhead plant vine	Abrus precatorius
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0605	Wu Wei Zi	五味子	Chinese magnoliavine	Schisandra chinensis
H0649	Xiang Si Zi	相思子	Coralhead plant	Abrus precatorius
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0609	Wu Wei Zi Liu Jin Gao	五味子流浸膏	Five-flavor berry	Schisandra chinensis
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H1226	Huai Shan Yao	淮山药	rhizome of biglcaf yam	Rhizoma dioscoreae
H0838	Zhu Zi Shen	珠子参	Largeleaf japanese ginseng rhizome	Rhizoma panacis majoris
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H0606	Wu Wei Zi Chun Jin Gao	五味子醇浸膏	Five-flavor berry	Schisandra chinensis
H0476	Can E	蚕蛾	Silkworm	Bombyx mori
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0608	Wu Wei Zi Jin Gao	五味子浸膏	Five-flavor berry	Schisandra chinensis
H0735	Yi Bei Mu	伊贝母	Siberian fritillary equivalent plant: fritillaria walujewii	Fritillaria pallidiflora

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 25)