HIT-result

Target Description

Type	Detail
Target ID	T80SD7
Protein Name	Sterol regulatory element-binding protein 2
Uniprot ID	Q12772
Protein Name Alias	SREBP-2; Class D basic helix-loop-helix protein 2; bHLHd2; Sterol regulatory element-binding transcription factor 2
Gene ID	6721
Gene Symbol	SREBF2
Gene Alias	BHLHD2; SREBP2
TTD	T03385: Research target
Pfam	PF00010
GO	0007399:nervous system development 0045542:positive regulation of cholesterol biosynthetic process 0005789:endoplasmic reticulum membrane 0019216:regulation of lipid metabolic process 0070888:E-box binding 0046983:protein dimerization activity 0042632:cholesterol homeostasis 0010886:positive regulation of cholesterol storage 0008593:regulation of Notch signaling pathway 1990837:sequence-specific double-stranded DNA binding 1903146:regulation of autophagy of mitochondrion 0008022:protein C-terminus binding 0009267:cellular response to starvation 0005829:cytosol 0006629:lipid metabolic process 0071404:cellular response to low-density lipoprotein particle stimulus 0008203:cholesterol metabolic process 1902895:positive regulation of pri-miRNA transcription by RNA polymerase II 0005654:nucleoplasm 0005737:cytoplasm 1903955:positive regulation of protein targeting to mitochondrion 0005783:endoplasmic reticulum 0000785:chromatin 0045944:positive regulation of transcription by RNA polymerase II 0032937:SREBP-SCAP-Insig complex 0071499:cellular response to laminar fluid shear stress 0005634:nucleus 0032933:SREBP signaling pathway 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0090370:negative regulation of cholesterol efflux 0000139:Golgi membrane 0001227:DNA-binding transcription repressor activity, RNA polymerase II-specific 0043231:intracellular membrane-bounded organelle 0045540:regulation of cholesterol biosynthetic process 0000122:negative regulation of transcription by RNA polymerase II 0012507:ER to Golgi transport vesicle membrane 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0006357:regulation of transcription by RNA polymerase II
PDB	1UKL
Drugbank	NA
KEGG	hsa:6721

Type

Detail

Target ID

T80SD7

Protein Name

Sterol regulatory element-binding protein 2

Uniprot ID

Q12772

Protein Name Alias

SREBP-2; Class D basic helix-loop-helix protein 2; bHLHd2; Sterol regulatory element-binding transcription factor 2

Gene ID

6721

Gene Symbol

SREBF2

Gene Alias

BHLHD2; SREBP2

TTD

T03385: Research target

Pfam

PF00010

0007399:nervous system development

0045542:positive regulation of cholesterol biosynthetic process

0005789:endoplasmic reticulum membrane

0019216:regulation of lipid metabolic process

0070888:E-box binding

0046983:protein dimerization activity

0042632:cholesterol homeostasis

0010886:positive regulation of cholesterol storage

0008593:regulation of Notch signaling pathway

1990837:sequence-specific double-stranded DNA binding

1903146:regulation of autophagy of mitochondrion

0008022:protein C-terminus binding

0009267:cellular response to starvation

0005829:cytosol

0006629:lipid metabolic process

0071404:cellular response to low-density lipoprotein particle stimulus

0008203:cholesterol metabolic process

1902895:positive regulation of pri-miRNA transcription by RNA polymerase II

0005654:nucleoplasm

0005737:cytoplasm

1903955:positive regulation of protein targeting to mitochondrion

0005783:endoplasmic reticulum

0000785:chromatin

0045944:positive regulation of transcription by RNA polymerase II

0032937:SREBP-SCAP-Insig complex

0071499:cellular response to laminar fluid shear stress

0005634:nucleus

0032933:SREBP signaling pathway

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0090370:negative regulation of cholesterol efflux

0000139:Golgi membrane

0001227:DNA-binding transcription repressor activity, RNA polymerase II-specific

0043231:intracellular membrane-bounded organelle

0045540:regulation of cholesterol biosynthetic process

0000122:negative regulation of transcription by RNA polymerase II

0012507:ER to Golgi transport vesicle membrane

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0006357:regulation of transcription by RNA polymerase II

PDB

1UKL

Drugbank

KEGG

hsa:6721

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H0607	Wu Wei Zi Jin Chu Wu	五味子浸出物	Five-flavor berry	Schisandra chinensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0287	Nao Yang Hua	闹羊花	Chinese azalea	Rhododendron molle
H0648	Xiang Si Teng	相思藤	Coralhead plant vine	Abrus precatorius
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0605	Wu Wei Zi	五味子	Chinese magnoliavine	Schisandra chinensis
H0649	Xiang Si Zi	相思子	Coralhead plant	Abrus precatorius
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0609	Wu Wei Zi Liu Jin Gao	五味子流浸膏	Five-flavor berry	Schisandra chinensis
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H1226	Huai Shan Yao	淮山药	rhizome of biglcaf yam	Rhizoma dioscoreae
H0838	Zhu Zi Shen	珠子参	Largeleaf japanese ginseng rhizome	Rhizoma panacis majoris
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H0606	Wu Wei Zi Chun Jin Gao	五味子醇浸膏	Five-flavor berry	Schisandra chinensis
H0476	Can E	蚕蛾	Silkworm	Bombyx mori
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0608	Wu Wei Zi Jin Gao	五味子浸膏	Five-flavor berry	Schisandra chinensis
H0735	Yi Bei Mu	伊贝母	Siberian fritillary equivalent plant: fritillaria walujewii	Fritillaria pallidiflora

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 24)