Target Description

Type Detail
Target ID T08VQQ
Protein Name Proprotein convertase subtilisin/kexin type 9
Uniprot ID Q8NBP7
Protein Name Alias EC 3.4.21.-;  Neural apoptosis-regulated convertase 1;  NARC-1;  Proprotein convertase 9;  PC9;  Subtilisin/kexin-like protease PC9
Gene ID 255738
Gene Symbol PCSK9
Gene Alias NARC1
TTD T62206: Successful target
Pfam PF18463 ; PF00082 ; PF18464 ; PF18459 ; PF05922
GO
0016540:protein autoprocessing

0005791:rough endoplasmic reticulum

0005615:extracellular space

0043523:regulation of neuron apoptotic process

0042632:cholesterol homeostasis

0007041:lysosomal transport

0022008:neurogenesis

1905601:negative regulation of receptor-mediated endocytosis involved in cholesterol transport

0044267:cellular protein metabolic process

1905596:negative regulation of low-density lipoprotein particle receptor binding

0009986:cell surface

0009267:cellular response to starvation

2000650:negative regulation of sodium ion transmembrane transporter activity

0010989:negative regulation of low-density lipoprotein particle clearance

0034190:apolipoprotein receptor binding

0005764:lysosome

0030182:neuron differentiation

0034383:low-density lipoprotein particle clearance

0005576:extracellular region

0001920:negative regulation of receptor recycling

0010469:regulation of signaling receptor activity

0034185:apolipoprotein binding

0006915:apoptotic process

0005794:Golgi apparatus

0005886:plasma membrane

1990666:PCSK9-LDLR complex

0005765:lysosomal membrane

0031232:extrinsic component of external side of plasma membrane

0008203:cholesterol metabolic process

0006644:phospholipid metabolic process

0043687:post-translational protein modification

0001822:kidney development

0005737:cytoplasm

0030134:COPII-coated ER to Golgi transport vesicle

0034189:very-low-density lipoprotein particle binding

0048471:perinuclear region of cytoplasm

0043525:positive regulation of neuron apoptotic process

0005783:endoplasmic reticulum

1990667:PCSK9-AnxA2 complex

0003723:RNA binding

0030547:receptor inhibitor activity

0032869:cellular response to insulin stimulus

0032805:positive regulation of low-density lipoprotein particle receptor catabolic process

0001889:liver development

1905598:negative regulation of low-density lipoprotein receptor activity

0050750:low-density lipoprotein particle receptor binding

0002092:positive regulation of receptor internalization

0006641:triglyceride metabolic process

0004252:serine-type endopeptidase activity

0032802:low-density lipoprotein particle receptor catabolic process

0030169:low-density lipoprotein particle binding

0036020:endolysosome membrane

0005769:early endosome

0005788:endoplasmic reticulum lumen

0019871:sodium channel inhibitor activity

0042157:lipoprotein metabolic process

0005770:late endosome

0070326:very-low-density lipoprotein particle receptor binding

0043621:protein self-association

PDB 4NE9 ; 2W2O ; 2XTJ ; 6U36 ; 5VLL ; 6U3I ; 6U38 ; 2PMW ; 3H42 ; 6MV5 ; 2W2P ; 3GCX ; 3P5C ; 3SQO ; 2W2Q ; 3BPS ; 2P4E ; 6U2F ; 5VLH ; 6U2N ; 6F5G ; 2W2N ; 2W2M ; 4NMX ; 2QTW ; 6E4Y ; 5OCA ; 6OM7 ; 4K8R ; 5VLP ; 5VLK ; 6OM0 ; 6E4Z ; 6U3X ; 6U26 ; 3GCW ; 3M0C ; 5VL7 ; 6U2P ; 6OLZ ; 4OV6 ; 3P5B ; 5VLA
Drugbank DB09302 ; DB14901 ; DB09303
KEGG hsa:255738

Related Compounds  (Total: 6)

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C0519
Name: Pinostrobin
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C0554
Name: Cholesterol
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C0867
Name: Alcohol
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C0873
Name: 10-Dehydrogingerdione
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C1138
Name: berberine


Related Herbs  (Total: 49)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0809 Zhi Mu知母 Common anemarrhenaAnemarrhena asphodeloides
H0651 Xiang Yuan香橼 Wilson citronCitrus medica
H0827 Zhu Hong Jun竹红菌 Bambusa hypocrella*Hypocrella bambusae
H0476 Can E蚕蛾 SilkwormBombyx mori
H0838 Zhu Zi Shen珠子参 Largeleaf japanese ginseng rhizomeRhizoma panacis majoris
H1042 Feng Shu Ye枫树叶 MapleAcer saccharum
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0648 Xiang Si Teng相思藤 Coralhead plant vineAbrus precatorius
H0357 Ren Shen人参 GinsengPanax ginseng
H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0609 Wu Wei Zi Liu Jin Gao五味子流浸膏 Five-flavor berrySchisandra chinensis
H0606 Wu Wei Zi Chun Jin Gao五味子醇浸膏 Five-flavor berrySchisandra chinensis
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H0083 Jiu Jie Cha九节茶 Glabrous sarcandraSarcandra glabra
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H1226 Huai Shan Yao淮山药 rhizome of biglcaf yamRhizoma dioscoreae
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H0735 Yi Bei Mu伊贝母 Siberian fritillary equivalent plant: fritillaria walujewiiFritillaria pallidiflora
H0652 Xiang Yuan Pi香橼皮 Wilson citronCitrus medica
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0042 Bai Tou Weng白头翁 Chinese pulsatillaPulsatilla chinensis
H0816 Chu Ling Dan臭灵丹 laggera pterodontaLaggera pterodonta
H0287 Nao Yang Hua闹羊花 Chinese azaleaRhododendron molle
H0607 Wu Wei Zi Jin Chu Wu五味子浸出物 Five-flavor berrySchisandra chinensis
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0522 Tai Zi Shen太子参 Heterophylly falsestarwort rootRadix pseudostellariae
H1021 E Da Xia莪大夏 NAOxytropis falcata
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0612 Cao Shan Hu Jin Gao草珊瑚浸膏 NASarcandra glabra
H0500 Can Yong蚕蛹 Silkworm chrysalisBombyx mori
H0608 Wu Wei Zi Jin Gao五味子浸膏 Five-flavor berrySchisandra chinensis
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0574 Cao Dou Kou草豆蔻 Katsumada galangalAlpinia katsumadai
H0649 Xiang Si Zi相思子 Coralhead plantAbrus precatorius
H0938 Da Suan大蒜 GarlicAllium sativum
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H0416 Shan Shen山参 NAPanax ginseng
H0821 Chu Ling Dan Cao臭灵丹草 laggera pterodontaLaggera pterodonta
H0605 Wu Wei Zi五味子 Chinese magnoliavineSchisandra chinensis
H0582 Cao Dou Kou Ren草豆蔻仁 Katsumada galangalAlpinia katsumadai