HIT-result

Target Description

Type	Detail
Target ID	T67U3B
Protein Name	Translocator protein
Uniprot ID	P30536
Protein Name Alias	Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; PBR
Gene ID	706
Gene Symbol	TSPO
Gene Alias	BZRP; MBR
TTD	T75440: Successful target
Pfam	PF03073
GO	0005741:mitochondrial outer membrane 0033574:response to testosterone 0042127:regulation of cell population proliferation 0008503:benzodiazepine receptor activity 0005829:cytosol 0010042:response to manganese ion 0014012:peripheral nervous system axon regeneration 0005497:androgen binding 0006783:heme biosynthetic process 0031397:negative regulation of protein ubiquitination 0032720:negative regulation of tumor necrosis factor production 0008202:steroid metabolic process 0043231:intracellular membrane-bounded organelle 0006700:C21-steroid hormone biosynthetic process 0032374:regulation of cholesterol transport 1903579:negative regulation of ATP metabolic process 0044325:ion channel binding 0005783:endoplasmic reticulum 0071476:cellular hypotonic response 0008347:glial cell migration 0070062:extracellular exosome 0016021:integral component of membrane 0045019:negative regulation of nitric oxide biosynthetic process 0006820:anion transport 0015485:cholesterol binding 0051928:positive regulation of calcium ion transport 0032570:response to progesterone 0060253:negative regulation of glial cell proliferation 0043065:positive regulation of apoptotic process 0048266:behavioral response to pain 0006869:lipid transport 1903147:negative regulation of autophagy of mitochondrion 0071222:cellular response to lipopolysaccharide 2000379:positive regulation of reactive oxygen species metabolic process 0072656:maintenance of protein location in mitochondrion 0006821:chloride transport 0051901:positive regulation of mitochondrial depolarization 0006626:protein targeting to mitochondrion 0042493:response to drug 0007568:aging 0010940:positive regulation of necrotic cell death 0060252:positive regulation of glial cell proliferation 0071294:cellular response to zinc ion 0010266:response to vitamin B1 0060242:contact inhibition 0050810:regulation of steroid biosynthetic process 0005739:mitochondrion 0030325:adrenal gland development
PDB	NA
Drugbank	DB01178 ; DB01198
KEGG	hsa:706

Type

Detail

Target ID

T67U3B

Protein Name

Translocator protein

Uniprot ID

P30536

Protein Name Alias

Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; PBR

Gene ID

706

Gene Symbol

TSPO

Gene Alias

BZRP; MBR

TTD

T75440: Successful target

Pfam

PF03073

0005741:mitochondrial outer membrane

0033574:response to testosterone

0042127:regulation of cell population proliferation

0008503:benzodiazepine receptor activity

0005829:cytosol

0010042:response to manganese ion

0014012:peripheral nervous system axon regeneration

0005497:androgen binding

0006783:heme biosynthetic process

0031397:negative regulation of protein ubiquitination

0032720:negative regulation of tumor necrosis factor production

0008202:steroid metabolic process

0043231:intracellular membrane-bounded organelle

0006700:C21-steroid hormone biosynthetic process

0032374:regulation of cholesterol transport

1903579:negative regulation of ATP metabolic process

0044325:ion channel binding

0005783:endoplasmic reticulum

0071476:cellular hypotonic response

0008347:glial cell migration

0070062:extracellular exosome

0016021:integral component of membrane

0045019:negative regulation of nitric oxide biosynthetic process

0006820:anion transport

0015485:cholesterol binding

0051928:positive regulation of calcium ion transport

0032570:response to progesterone

0060253:negative regulation of glial cell proliferation

0043065:positive regulation of apoptotic process

0048266:behavioral response to pain

0006869:lipid transport

1903147:negative regulation of autophagy of mitochondrion

0071222:cellular response to lipopolysaccharide

2000379:positive regulation of reactive oxygen species metabolic process

0072656:maintenance of protein location in mitochondrion

0006821:chloride transport

0051901:positive regulation of mitochondrial depolarization

0006626:protein targeting to mitochondrion

0042493:response to drug

0007568:aging

0010940:positive regulation of necrotic cell death

0060252:positive regulation of glial cell proliferation

0071294:cellular response to zinc ion

0010266:response to vitamin B1

0060242:contact inhibition

0050810:regulation of steroid biosynthetic process

0005739:mitochondrion

0030325:adrenal gland development

PDB

Drugbank

DB01178 ; DB01198

KEGG

hsa:706

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0104	Bai Zhu	白术	Largehead atractylodes	Atractylodes macrocephala
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H0609	Wu Wei Zi Liu Jin Gao	五味子流浸膏	Five-flavor berry	Schisandra chinensis
H0648	Xiang Si Teng	相思藤	Coralhead plant vine	Abrus precatorius
H0427	Shan Zhu Yu	山茱萸	Asiatic cornelian cherry	Cornus officinalis
H0972	Di Huang	地黄	Rehmanniae	Rehmannia glutinosa
H0605	Wu Wei Zi	五味子	Chinese magnoliavine	Schisandra chinensis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0606	Wu Wei Zi Chun Jin Gao	五味子醇浸膏	Five-flavor berry	Schisandra chinensis
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H1226	Huai Shan Yao	淮山药	rhizome of biglcaf yam	Rhizoma dioscoreae
H0608	Wu Wei Zi Jin Gao	五味子浸膏	Five-flavor berry	Schisandra chinensis
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H0417	Shan Yao	山药	Common yam	Dioscorea batatas
H1200	Bai Mao Gen	白茅根	Lalang grass rhizome	Imperata cylindrica
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H0735	Yi Bei Mu	伊贝母	Siberian fritillary equivalent plant: fritillaria walujewii	Fritillaria pallidiflora
H0838	Zhu Zi Shen	珠子参	Largeleaf japanese ginseng rhizome	Rhizoma panacis majoris
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0607	Wu Wei Zi Jin Chu Wu	五味子浸出物	Five-flavor berry	Schisandra chinensis
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H0537	Tian Dong	天冬	Cochinchinese asparagus root	Asparagus cochinchinensis
H0476	Can E	蚕蛾	Silkworm	Bombyx mori
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0649	Xiang Si Zi	相思子	Coralhead plant	Abrus precatorius
H0287	Nao Yang Hua	闹羊花	Chinese azalea	Rhododendron molle

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 32)