Target Description

Type Detail
Target ID T79UHV
Protein Name Prolow-density lipoprotein receptor-related protein 1
Uniprot ID Q07954
Protein Name Alias LRP-1;  Alpha-2-macroglobulin receptor;  A2MR;  Apolipoprotein E receptor;  APOER;  CD antigen CD91
Gene ID 4035
Gene Symbol LRP1
Gene Alias A2MR;  APR
TTD T91130: Research target
Pfam PF00058 ; PF00057 ; PF12662 ; PF07645 ; PF16472
GO
0005044:scavenger receptor activity

0032956:regulation of actin cytoskeleton organization

0043235:receptor complex

0016323:basolateral plasma membrane

0005925:focal adhesion

0043524:negative regulation of neuron apoptotic process

1905049:negative regulation of metallopeptidase activity

0045177:apical part of cell

1904646:cellular response to amyloid-beta

0061642:chemoattraction of axon

0005634:nucleus

0005509:calcium ion binding

0070325:lipoprotein particle receptor binding

0010875:positive regulation of cholesterol efflux

0045056:transcytosis

0045807:positive regulation of endocytosis

0097242:amyloid-beta clearance

1900149:positive regulation of Schwann cell migration

0048691:positive regulation of axon extension involved in regeneration

0010942:positive regulation of cell death

0003723:RNA binding

0006909:phagocytosis

2000343:positive regulation of chemokine (C-X-C motif) ligand 2 production

0031623:receptor internalization

0007205:protein kinase C-activating G protein-coupled receptor signaling pathway

0032374:regulation of cholesterol transport

1904109:positive regulation of cholesterol import

0051895:negative regulation of focal adhesion assembly

0150093:amyloid-beta clearance by transcytosis

0005886:plasma membrane

0007204:positive regulation of cytosolic calcium ion concentration

0001523:retinoid metabolic process

0050766:positive regulation of phagocytosis

1904754:positive regulation of vascular associated smooth muscle cell migration

0032593:insulin-responsive compartment

0005041:low-density lipoprotein particle receptor activity

0008283:cell population proliferation

0032050:clathrin heavy chain binding

1905167:positive regulation of lysosomal protein catabolic process

0015026:coreceptor activity

0002265:astrocyte activation involved in immune response

0043277:apoptotic cell clearance

0005905:clathrin-coated pit

0038023:signaling receptor activity

2000587:negative regulation of platelet-derived growth factor receptor-beta signaling pathway

0030178:negative regulation of Wnt signaling pathway

1903078:positive regulation of protein localization to plasma membrane

0014912:negative regulation of smooth muscle cell migration

0006898:receptor-mediated endocytosis

0016020:membrane

0001540:amyloid-beta binding

0030425:dendrite

0005769:early endosome

0005765:lysosomal membrane

1904300:positive regulation of transcytosis

0043025:neuronal cell body

0030136:clathrin-coated vesicle

0035774:positive regulation of insulin secretion involved in cellular response to glucose stimulus

0044242:cellular lipid catabolic process

0032092:positive regulation of protein binding

0035909:aorta morphogenesis

0032370:positive regulation of lipid transport

0021987:cerebral cortex development

0032429:regulation of phospholipase A2 activity

0007568:aging

0048694:positive regulation of collateral sprouting of injured axon

0005887:integral component of plasma membrane

0043395:heparan sulfate proteoglycan binding

0150094:amyloid-beta clearance by cellular catabolic process

0070374:positive regulation of ERK1 and ERK2 cascade

0044877:protein-containing complex binding

0150104:transport across blood-brain barrier

0051481:negative regulation of cytosolic calcium ion concentration

0044295:axonal growth cone

0030226:apolipoprotein receptor activity

0007041:lysosomal transport

0098797:plasma membrane protein complex

0016964:alpha-2 macroglobulin receptor activity

0006629:lipid metabolic process

0030666:endocytic vesicle membrane

1900223:positive regulation of amyloid-beta clearance

0038024:cargo receptor activity

0034185:apolipoprotein binding

0010715:regulation of extracellular matrix disassembly

0042157:lipoprotein metabolic process

0005856:cytoskeleton

0042953:lipoprotein transport

0150051:postsynaptic Golgi apparatus

0002020:protease binding

0010977:negative regulation of neuron projection development

PDB 1J8E ; 2FYL ; 1CR8 ; 1D2L ; 2KNX ; 2KNY ; 2FYJ
Drugbank DB13998 ; DB13999 ; DB00031 ; DB00100 ; DB00025 ; DB06245 ; DB13152
KEGG hsa:4035

Related Compounds  (Total: 2)

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C0554
Name: Cholesterol
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C1234
Name: Cholesterol


Related Herbs  (Total: 24)

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H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0607 Wu Wei Zi Jin Chu Wu五味子浸出物 Five-flavor berrySchisandra chinensis
H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0476 Can E蚕蛾 SilkwormBombyx mori
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0649 Xiang Si Zi相思子 Coralhead plantAbrus precatorius
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